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Remember and know judgments during recognition in chronic schizophrenia.

Abstract：

:Deficits in learning and memory are among the most robust correlates of schizophrenia. It has been hypothesized that these deficits are in part due to reduced conscious recollection and increased reliance on familiarity assessment as a basis for retrieval. The Remember-Know (R-K) paradigm was administered to 35 patients with chronic schizophrenia and 35 healthy controls. In addition to making "remember" and "know" judgments, the participants were asked to make forced-choice recognition judgments with regard to details about the learning episode. Analyses comparing response types showed a significant reduction in "remember" responses and a significant increase in "know" responses in schizophrenia patients relative to controls. Both patients and controls recalled more details of the learning episode for "remember" compared to "know" responses, although, in particular for "remember" responses, patients recalled fewer details compared with controls. Notably, patients recognized fewer inter-item but not intra-item stimulus features compared with controls. These findings suggest deficits in organizing and integrating relational information during the learning episode and/or using relational information for retrieval. A Dual-Process Signal Detection interpretation of these findings suggests that recollection in chronic schizophrenia is significantly reduced, while familiarity is not. Additionally, a unidimensional Signal Detection Theory interpretation suggests that chronic schizophrenia patients show a reduction in memory strength, and an altered criterion on the memory strength distribution for detecting new compared with old stimuli but not for detecting stimuli that are remembered versus familiar. Taken together, these findings are consistent with a deficit in recollection and increased reliance on familiarity in making recognition memory judgments in chronic schizophrenia.

journal_name

Schizophr Res

journal_title

Schizophrenia research

authors

van Erp TG,Lesh TA,Knowlton BJ,Bearden CE,Hardt M,Karlsgodt KH,Shirinyan D,Rao V,Green MF,Subotnik KL,Nuechterlein K,Cannon TD

doi

10.1016/j.schres.2007.09.021

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

181-90

issue

1-3

eissn

0920-9964

issn

1573-2509

pii

S0920-9964(07)00424-0

journal_volume

100

pub_type

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Remember and know judgments during recognition in chronic schizophrenia.