Abstract:
BACKGROUND:The extent of heterogeneity in the long-term course of schizophrenia is unclear. AIMS:To examine the course of schizophrenia in a population-based cohort. METHODS:This study included all Israeli individuals born in 1970-1988, of North African or European origin (N=2290), entered in the National Psychiatric Hospitalization Case Registry with a last discharge diagnosis of schizophrenia (1978-2004) and followed to 2009. Linked socio-demographic information was extracted from the Population Registry. Based on the number of hospitalized days at each age, trajectory groups were empirically derived, plotted and compared on psychiatric hospitalization measures of the course of illness, social factors and family stressors. RESULTS:Trajectory analysis identified four course groups. Group I (57%) assumed a prototypical course, had an average first hospitalization age of 20, deteriorated until 23 and then ameliorated. Group II (15.5%) assumed an early-onset protracted course, had an average first hospitalization age of 17.1, and deteriorated until 21. Group III (15%) assumed a late-onset with longest deterioration period course, had an average first hospitalization age of 22.7, and deteriorated until 29. Group IV (12%) assumed an early-onset refractory illness course, had an average first hospitalization age of 18, and had the longest hospitalization period. Groups significantly differed on hospitalization (i.e., onset), social (i.e., socioeconomic and ethnic status) and familial factors (i.e., parental death). Despite group differences all deteriorated and then ameliorated on average by the age of 23. CONCLUSIONS:The course of schizophrenia was heterogeneous, yet evolved from deterioration to assume a course consistent with amelioration.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Levine SZ,Lurie I,Kohn R,Levav Idoi
10.1016/j.schres.2010.10.026subject
Has Abstractpub_date
2011-03-01 00:00:00pages
184-91issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(10)01601-4journal_volume
126pub_type
杂志文章abstract:OBJECTIVE:Neuregulin-1 (NRG1) has been put forward as a susceptibility gene for schizophrenia. We investigated the association between Neuregulin-1 and the P300 wave, a schizophrenia endophenotype. METHODS:Participants were 64 patients with DSM-IV schizophrenia or schizoaffective disorder, 97 of their non psychotic re...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2008.03.025
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVE:The relationship of religion and schizophrenia is widely acknowledged, but often minimized by practitioners and under investigated by researchers. In striving to help fill this gap, this paper focuses on examining four aims: 1) how research has investigated the association between religiosity and schizophreni...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2010.11.005
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Cannabis and cocaine are the most common illicit drugs for which people are treated in addiction services in Latin America. Much research has suggested that the use of cannabis increases the risk of schizophrenia; there is less evidence concerning cocaine. The aim of the present study was to establish the re...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2017.04.010
更新日期:2018-04-01 00:00:00
abstract::Deficits in nonverbal vocal expression (e.g., blunted vocal affect, alogia) are a hallmark of schizophrenia and are a focus of the Research Domain Criteria initiative from the National Institute of Mental Health. Results from studies using symptom rating scales suggest that these deficits are profound; on the order of...
journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.schres.2014.09.013
更新日期:2014-11-01 00:00:00
abstract::Primary motor abnormalities (PMA), as found in patients with schizophrenia, are quantitatively and qualitatively distinct markers of motor system abnormalities. PMA have been often referred to phenomena that are present across schizophrenia-spectrum disorders. A dysfunction of frontoparietal and subcortical networks h...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2017.10.007
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:Despite an increased risk for suicide among individuals diagnosed with psychotic disorders, risk factors for completed suicide remain largely unexamined in this population. Using a case-control design, this study aimed to investigate clinical and behavioural risk factors for suicide completion in schizophreni...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2006.02.025
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:Numerous studies have examined a wide range of risk factors associated with violence among patients with schizophrenia. However, risk factors linked to different socio-cultural backgrounds remain unclear. OBJECTIVE:The objectives were to investigate factors associated with violence among Japanese patients w...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.10.016
更新日期:2014-12-01 00:00:00
abstract::This is the first study to investigate whether positive family history (FH) of psychosis and affective disorders moderates the relationship between child diagnostic status and parent-reported social and behavioral problems on the Child Behavior Checklist (CBCL) in clinical high-risk adolescents. This longitudinal inve...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.04.027
更新日期:2015-08-01 00:00:00
abstract::Antipsychotic pharmacotherapy is the standard of care for the treatment of schizophrenia. Although pharmacotherapy effectively improves some symptoms, others can remain. Pharmacotherapy alone also tends to produce only limited improvement in social functioning and quality of life. Supportive psychosocial therapies hav...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2007.12.468
更新日期:2008-03-01 00:00:00
abstract::Motion-induced blindness (MIB) occurs when target stimuli are presented together with a moving distractor pattern. Most observers experience the targets disappearing and reappearing repeatedly for periods of up to several seconds. MIB can be viewed as a striking marker for the organization of cognitive functioning. In...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2005.08.012
更新日期:2006-01-31 00:00:00
abstract::The etiologic factors underlying schizophrenia have been conceptualized as reflecting two largely genetic components - those unique to schizophrenia and those representing vulnerability to neurodevelopmental deviation in general. The Developmental Instability (DI) approach suggests that the latter can be indexed by mi...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.08.014
更新日期:2009-11-01 00:00:00
abstract::In a 12-week randomized open-label trial, adults diagnosed with schizophrenia experiencing inadequate efficacy and/or poor tolerability on risperidone, olanzapine, or aripiprazole were randomized to switch to iloperidone either gradually (ie, down-titration of current therapy over the first 2weeks [to 50% on Day 1, 25...
journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2013.11.042
更新日期:2014-03-01 00:00:00
abstract::This study reports findings of the Edinburgh High Risk Study four years after it began. This study is designed to explore the pathogenesis of schizophrenia by examining a large sample of young adults aged 16-25 years who are at enhanced risk of developing schizophrenia by having two close relatives with the disorder, ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(99)00225-x
更新日期:2000-11-30 00:00:00
abstract::The natural history of neurocognitive impairments in schizophrenia is unclear. We aimed to characterise this in an epidemiological first-episode cohort and relate it to long-term outcome. All but 1 of 112 first-episode psychosis cases ascertained from a geographical catchment area were traced at 10-12 years. Neurocogn...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(03)00014-8
更新日期:2003-12-15 00:00:00
abstract::Patients with schizophrenia often exhibit structural brain abnormalities, as well as neurological soft signs (NSS), consistent with its conceptualization as a neurodevelopmental disorder. NSS are mild, presumably nonlocalizing, neurological impairments that are inferred from performance deficits in domains such as sen...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.06.018
更新日期:2009-12-01 00:00:00
abstract::Second generation antipsychotics cause derangements in glucose metabolism that are often interpreted as insulin resistance. In previous studies we have shown that this is not classical insulin resistance but the drugs were actually inducing a hyperglycaemic state associated with elevated hepatic glucose output (HGO) a...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.05.003
更新日期:2014-08-01 00:00:00
abstract::Research suggests that social stress exposure influences illness presentation and course among youth at clinical high-risk (CHR) for psychosis, though less is known about the extent to which self-reported perceptions of social stress relate to the severity of positive symptoms. Importantly, despite the notion that you...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2017.06.002
更新日期:2018-02-01 00:00:00
abstract::While the long-term administration of antipsychotics is known to cause dopamine supersensitivity psychosis (DSP), recent studies revealed that DSP helps form the foundation of treatment resistance. Electroconvulsive shock (ES) is one of the more effective treatments for treatment-resistant schizophrenia. The objective...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2020.11.062
更新日期:2021-01-08 00:00:00
abstract::The dot pattern expectancy (DPX) task has been strongly recommended as a measure of goal maintenance, which is impaired in schizophrenia patients. The current event-related potential (ERP) study was designed mainly to identify the ERP component that could represent the goal maintenance process of the DPX task as index...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2017.09.038
更新日期:2018-05-01 00:00:00
abstract::Planning and executing goal-directed behaviours are critical final steps in translating motivation into action. Amotivation is a key feature of schizophrenia, but its impact on goal-directed functioning has not been extensively studied in an objective and ecologically valid manner. To address this, we investigated goa...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2018.10.012
更新日期:2019-04-01 00:00:00
abstract::Brain morphometry has been studied extensively in schizophrenic patients, and among the cortical differences identified two consistent findings are decreased cerebellar vermal volume and increased volume of the fourth ventricle; although contradictory findings are reported as well. Recent cognitive activation studies ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(98)00137-6
更新日期:1999-05-04 00:00:00
abstract::Heterozygous reeler mouse has been used as an animal model for schizophrenia based on several neuropathological and behavioral abnormalities homologous to schizophrenia. Since some of these abnormalities are primarily associated with altered BDNF signaling we investigated BDNF signaling in the frontal cortex of reeler...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2007.11.030
更新日期:2008-03-01 00:00:00
abstract::In previous studies of self-monitoring in schizophrenia, patients have exhibited reductions in the amplitude of the error-related negativity (ERN), a component of the event-related brain potential (ERP) elicited most prominently immediately following the execution of incorrect responses. In the current study, we exami...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2007.08.027
更新日期:2008-02-01 00:00:00
abstract::The involvement of the gamma-aminobutyric acid (GABA) system in schizophrenia is suggested by postmortem studies and the common use of GABA receptor-potentiating agents in treatment. In a recent study, we used a benzodiazepine challenge to demonstrate abnormal GABAergic function during processing of negative visual st...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.08.022
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVES:This nation-wide register-based study investigates the family load of schizophrenia (SZ) across three generations in affected families compared to control families. Furthermore the study compares the family load in case vs. control families considering the age of onset of the disorder in the cases. In additi...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2012.05.014
更新日期:2012-08-01 00:00:00
abstract::NRG1 is one of the most researched genes associated with schizophrenia. Although three meta-analyses in this area have been published, the results have been inconclusive and even conflicting. Family based studies can be problematical due to the difficulty of synthesizing them with case-control studies. Heterogeneity i...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.03.017
更新日期:2009-06-01 00:00:00
abstract::Catatonia is a severe psychomotor syndrome that frequently occurs in patients with schizophrenia spectrum disorders (SSD). Accumulating neuroimaging evidence suggests orbitofrontal, frontoparietal and cerebellar network dysfunction in catatonia. Very little is known about contributions of brainstem regions (as part of...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2020.09.025
更新日期:2020-10-01 00:00:00
abstract::Numerous studies have described attenuated event-related potential (ERP) component amplitudes in schizophrenia (e.g., P300, Mismatch Negativity (MMN), Error Negativity/Error-Related Negativity (Ne/ERN)). Functional magnetic resonance imaging (fMRI) studies have typically shown decreased recruitment of diverse brain ar...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.09.036
更新日期:2009-12-01 00:00:00
abstract::Schizophrenia is associated with subtle developmental compromise, but the degree to which this is also associated with heritability and genetic risk is uncertain. The goal of the current study was to investigate the childhood, adolescent, and early adulthood social and academic function of patients with schizophrenia,...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.04.007
更新日期:2009-07-01 00:00:00
abstract::Genetic factors that modulate the immune response have been implicated as risk factors for schizophrenia and cognitive impairment. We assessed the correlation between cognitive functioning and the LTA Cys13Arg polymorphism in 351 individuals with schizophrenia, 122 with bipolar disorder, and 160 controls. There was a ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2006.08.015
更新日期:2007-01-01 00:00:00