Abstract：
:Genetic factors that modulate the immune response have been implicated as risk factors for schizophrenia and cognitive impairment. We assessed the correlation between cognitive functioning and the LTA Cys13Arg polymorphism in 351 individuals with schizophrenia, 122 with bipolar disorder, and 160 controls. There was a significant association between cognitive functioning and the LTA Cys13Arg polymorphism within the schizophrenia (p<0.008) but not the other diagnostic groups. There was no association between cognitive functioning and the two other polymorphisms in the same gene complex. The LTA Cys13Arg polymorphism may represent a risk factor for cognitive impairment in individuals with schizophrenia.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Dickerson F,Boronow J,Stallings C,Origoni A,Yolken Rdoi
10.1016/j.schres.2006.08.015subject
Has Abstractpub_date
2007-01-01 00:00:00pages
173-6issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(06)00362-8journal_volume
89pub_type
杂志文章abstract：OBJECTIVE:Clozapine is associated with significant weight gain. However, it is still debatable whether the majority of weight gain occurs in the early phase of treatment or if weight gain is a persistent side effect. The inconsistent results in previous outpatient studies may be due to many confounding factors, such as...
journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章
doi：10.1016/j.schres.2008.10.023
更新日期：2009-03-01 00:00:00
abstract：OBJECTIVE:Corpus callosum (CC) size and interhemispheric communication differences have been reported between patients with schizophrenia and normal controls. Childhood-onset schizophrenia (COS) is a severe form of the disorder that is continuous with later-onset disorder. Corpus callosal area was examined for COS at i...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(02)00354-7
更新日期：2003-07-01 00:00:00
abstract：:The involvement of the gamma-aminobutyric acid (GABA) system in schizophrenia is suggested by postmortem studies and the common use of GABA receptor-potentiating agents in treatment. In a recent study, we used a benzodiazepine challenge to demonstrate abnormal GABAergic function during processing of negative visual st...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.08.022
更新日期：2015-10-01 00:00:00
abstract：:There is strong evidence that hippocampal 5-hydroxytryptamine (5-HT) systems are affected in schizophrenia and hence we have studied a number of markers of the 5-HT system in hippocampi from subjects with schizophrenia. Using in situ radioligand binding with autoradiography we measured [(3)H]proplyamino-8-hydroxy-1,2,...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2004.02.007
更新日期：2004-12-01 00:00:00
abstract：:Social anhedonia is an important feature of schizophrenia and it is a promising indicator of schizotypy. Although social anhedonia is defined as an affective construct (less pleasure derived from social encounters), little is known about the emotional responsivity and expressivity of individuals with high levels of so...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2010.06.012
更新日期：2010-12-01 00:00:00
abstract：:Auditory-verbal hallucinations (AVHs) are associated with an impaired connectivity of large-scale networks. To examine the relationship between white-matter integrity and AVHs, we conducted a meta-analysis of diffusion-tensor-imaging studies that compared patients with schizophrenia and AVHs with matched healthy contr...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析
doi：10.1016/j.schres.2014.07.014
更新日期：2014-10-01 00:00:00
abstract：OBJECTIVES:The impact of cannabis use on the brain tissue is still unclear, both in the healthy developing brain and in people with schizophrenia. The focus of this review is on white matter, the primary connective infrastructure of the brain. METHODS:We systematically reviewed diffusion tensor imaging (DTI) studies o...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2014.04.026
更新日期：2014-07-01 00:00:00
abstract：OBJECTIVE:Following encouraging results in the early detection of psychotic disorders, interest in the early detection of affective, especially bipolar disorders, has recently been renewed. However, the differentiation between affective disorders with and without psychotic features is often missing, although it has bee...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.04.001
更新日期：2012-07-01 00:00:00
abstract：:Recovery-oriented practices that promote client-centered care, collaboration, and functional outcome have been recommended to improve treatment engagement, especially for individuals with serious mental illness (SMI). Psychological well-being (PWB) is related to recovery and refers to experiencing purpose and meaning ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.11.032
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:Negative symptoms are a core feature of schizophrenia. The evolution and trajectory of primary negative symptoms were under-studied. We aimed at evaluating the prevalence and stability of primary negative symptoms, and factors associated with persistent primary negative symptoms in a first-episode sample. M...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2011.09.006
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND:While the functional disconnectivity hypothesis of schizophrenia has received considerable attention, fewer studies have investigated the contribution of genotype to structural connectivity between brain regions either in schizophrenia patients or in healthy controls. In this study, we obtained diffusion ten...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.03.003
更新日期：2014-05-01 00:00:00
abstract：:A literature review and power analysis of longitudinal studies published since 1997 investigating the trajectory of neurocognitive deficits across time in patients with schizophrenia was conducted. Ten studies were identified, evaluating a total of 834 patients with mean ages of 24.0-77.8 years at study entry. Power e...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2004.07.005
更新日期：2005-04-01 00:00:00
abstract：:Although patients with schizophrenia have reduced brain size, there is no conclusive evidence that they have reduced head size. This begs the question: 'What is the precise relationship between head size and brain size?' We used a unique osteological collection to explore the relationship between external head measure...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(99)00098-5
更新日期：2000-03-16 00:00:00
abstract：:We investigated IL1B genetic variation previously associated with risk for transition to psychosis for its association with gene expression in human post-mortem dorsolateral prefrontal cortex (DLPFC) from 74 (37 schizophrenia, 37 control) individuals and brain structure in 92 (44 schizophrenia, 48 control) living indi...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.09.008
更新日期：2019-02-01 00:00:00
abstract：:Second generation antipsychotics cause derangements in glucose metabolism that are often interpreted as insulin resistance. In previous studies we have shown that this is not classical insulin resistance but the drugs were actually inducing a hyperglycaemic state associated with elevated hepatic glucose output (HGO) a...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.05.003
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:Gamma-aminobutyric acid (GABA) dysfunction and its consequent imbalance are implicated in the pathophysiology of schizophrenia. Reduced GABA production would lead to a disinhibition of glutamatergic neurons and subsequently cause a disruption of the modulation between GABAergic interneurons and glutamatergic...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.07.021
更新日期：2018-03-01 00:00:00
abstract：:In recent years, early intervention services have attempted to identify people with a first episode of psychosis as early as possible, reducing the duration of untreated psychosis and changing the timing of delivery of interventions. The logic of early intervention is based partly on accessing people in a more treatme...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2010.02.1071
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND:There is increased interest in the impact of new long-acting treatments on health-related quality of life (HRQoL) in patients with schizophrenia. The aim of this study was to evaluate the impact of treatment with subcutaneous injections of RBP-7000, a new sustained-release formulation of risperidone, compare...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.schres.2016.03.020
更新日期：2016-07-01 00:00:00
abstract：:The aim of this study is to compare the neurocognitive functions in individuals with clinical or genetic risk for psychosis, in patients with first-episode schizophrenia (FES) and in healthy controls. We compared cognitive functions of 52 individuals at ultra high risk (UHR) for psychosis, 53 patients with FES, their ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.10.030
更新日期：2013-12-01 00:00:00
abstract：:Most individuals with schizophrenia will be confronted with some form of stigma. In recent years, clinicians and family members have increasingly contested the term "schizophrenia". Many of them discuss changing this name, as a means to fight stigma. Up until now, surprisingly, most research has been conducted using s...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.11.054
更新日期：2020-02-01 00:00:00
abstract：INTRODUCTION:Progressive atrophy occurs in brain regions involved in the working memory network along the schizophrenia's course, but without parallel evolution of working memory impairment. We investigated the functional organization inside this network at different stages of the disease. METHODS:Twenty-eight patient...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.10.023
更新日期：2013-12-01 00:00:00
abstract：:To clarify the molecular mechanism of phencyclidine (PCP)-induced schizophreniform psychosis in humans and of behavioral abnormalities in experimental animals, we used differential screening of a cDNA library from the cerebral cortex of rats treated with PCP. We identified a PCP-induced cDNA clone as the gene encoding...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(97)00029-7
更新日期：1997-06-20 00:00:00
abstract：:Patients with schizophrenia and bipolar disorder (BD) shared a significant overlap in genetic susceptibility, pharmacological treatment responses, neuropsychological deficits, and epidemiological features. However, it remains unknown whether these clinical overlaps are mediated by shared or disorder-specific abnormali...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析
doi：10.1016/j.schres.2017.01.005
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:Findings from the WHO sponsored multicenter studies done a few decades ago, which reported favorable outcome of schizophrenia in developing countries both in 2 and 5 year follow-up studies, dominated the world view until recently. Emerging evidence from Low and Middle Income countries (LAMIC) started to chal...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.schres.2011.10.021
更新日期：2012-04-01 00:00:00
abstract：:In schizophrenia, clinical, familial and biological characteristics according to age at onset (AAO) suggest that AAO is a valid candidate symptom for genetic studies. However, none of the various thresholds used to define AAO subgroups in schizophrenia has been validated. We aim to define different AAO subtypes by adm...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2004.02.002
更新日期：2004-11-01 00:00:00
abstract：:Neurological Examination Abnormalities (NEA) are prevalent in schizophrenia, but the significance of this is obscured by methodological problems. The Neurological Evaluation Scale (NES), the most widely used structured neurological examination in schizophrenia research, has had limited study of its inter-rater reliabi...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(97)00103-5
更新日期：1998-02-09 00:00:00
abstract：:The present study determined the minimal exposure time (i.e., critical stimulus duration (CSD) necessary for feature registration and recognition by normals and chronic schizophrenics. Our interest was whether the longer exposure times required by schizophrenics than by normals could be attributed to an inability of s...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(92)90049-b
更新日期：1992-07-01 00:00:00
abstract：:The way schizophrenia patients perceive the world is largely mysterious. Understanding and appreciating the visual world begins with the perception of basic visual features, which is altered in this mental disorder. Yet, the roles basic visual features play in functional activities such as appreciation of art are uncl...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2008.06.024
更新日期：2008-10-01 00:00:00
abstract：:Pro-inflammatory cytokines have been consistently reported to be elevated in schizophrenia patients. However, it is not known whether cytokines influence the presentation of psychotic symptoms. To address this issue, we evaluated the relationship between levels of inflammatory molecules and psychopathological paramete...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.10.019
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:The aim of this study is to determine the rate of persistent negative symptoms according to different criteria during two years of follow-up after first-episode schizophrenia. METHODS:The study sample consisted of 105 patients with first-episode schizophrenia who completed at least 12 months of follow-up pe...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.07.021
更新日期：2014-09-01 00:00:00
