Abstract：
:Recovery-oriented practices that promote client-centered care, collaboration, and functional outcome have been recommended to improve treatment engagement, especially for individuals with serious mental illness (SMI). Psychological well-being (PWB) is related to recovery and refers to experiencing purpose and meaning in life through realizing one's potential. The recently completed Recovery After an Initial Schizophrenia Episode Early Treatment Program (RAISE ETP) study sought to improve quality of life, functional outcome, and well-being in individuals with first episode psychosis (FEP). Therefore, the primary aims of the present analysis were: 1) to examine the impact of treatment on PWB and mental health recovery trajectories, 2) to examine the impact of duration of untreated psychosis (DUP) on these outcomes, and 3) to examine the relationships among these outcomes and quality of life. Multilevel modeling was used given the nested data structure. Results revealed that PWB and mental health recovery improved over the course of the 2-year treatment; there were no significant treatment differences. In addition, DUP was associated with the Positive Relationships and Environmental Mastery dimensions of PWB. Finally, PWB, mental health recovery, and quality of life were all significantly correlated at baseline while controlling for depressive symptoms. Overall, the findings indicate that PWB and mental health recovery can improve in FEP, are related to yet distinct from quality of life, and that DUP may play a role in certain facets of these constructs.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Browne J,Penn DL,Meyer-Kalos PS,Mueser KT,Estroff SE,Brunette MF,Correll CU,Robinson J,Rosenheck RA,Schooler N,Robinson DG,Addington J,Marcy P,Kane JMdoi
10.1016/j.schres.2016.11.032subject
Has Abstractpub_date
2017-07-01 00:00:00pages
167-172eissn
0920-9964issn
1573-2509pii
S0920-9964(16)30525-4journal_volume
185pub_type
杂志文章abstract：:There is growing awareness that reduced expressive behaviors (e.g., blunt affect, alogia, psychomotor retardation) are characteristic of a range of psychiatric conditions, including mood and schizophrenia-spectrum disorders. From a Research Domain Criteria (RDoC) perspective, it would be critical to determine whether ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.07.001
更新日期：2012-09-01 00:00:00
abstract：:It has been proposed that certain psychotic symptoms associated with schizophrenia reflect a deficit in the ability to appreciate other people's mental states (Frith, 1992). This notion is tested using a newly devised task examining the capacity to infer intentions behind indirect speech. The findings support the noti...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(95)00024-g
更新日期：1995-09-01 00:00:00
abstract：OBJECTIVE:We recently reported that the type-2 cytokine response is increased in schizophrenia. The aim of this study was to analyse the effects of antipsychotic drugs on the serum levels of type-1 (TNF-α, IFN-γ), type-2 (IL-4, IL-10), type-17 (IL-17) and regulatory cytokines (TGF-β, IL-27 and IL-6). METHODS:Cytokine ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.03.027
更新日期：2013-06-01 00:00:00
abstract：:Recent preclinical and clinical evidence suggests that the stearoyl-CoA desaturase-1 (Scd1) enzyme plays a key role in the regulation of triglyceride (TG) biosynthesis and insulin sensitivity, and in vitro studies have found that antipsychotic medications up-regulate Scd1 mRNA expression. To investigate these effects ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2011.03.016
更新日期：2011-06-01 00:00:00
abstract：:Cognitive impairments have been shown to predict impairments in adaptive functioning in patients with chronic schizophrenia and to be more predictive of overall outcome than positive or negative symptoms of the illness. Both adaptive and cognitive impairments are multidimensional, and it is possible that correlations ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/S0920-9964(97)00068-6
更新日期：1997-10-30 00:00:00
abstract：OBJECTIVE:While "dual diagnosis" involving both psychiatric and substance use disorders has long been a focus of schizophrenia research, recent studies have advocated for a shift of focus to multimorbidity, addressing comorbidity from both additional psychiatric disorders and substance use disorders. We hypothesized th...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2018.04.035
更新日期：2018-11-01 00:00:00
abstract：:Past studies have shown that schizophrenic men tend to be impaired on the olfactory identification task. We examined individual differences in the olfactory function in relation to schizotypy. Healthy individuals who might carry latent liability for schizophrenia participated in olfactory identification and acuity tas...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(97)00045-5
更新日期：1997-08-29 00:00:00
abstract：BACKGROUND:Severity of negative symptoms has been associated with poor functioning, cognitive deficits, and defeatist beliefs in schizophrenia patients. However, one area that remains understudied is persistent negative symptoms (PNS). Negative symptoms, including PNS, have been observed in those at clinical high-risk ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2020.04.004
更新日期：2020-04-30 00:00:00
abstract：:We previously reported a schizophrenia associated reduction of neuronal and oligodendrocyte number in the anterior principal thalamic nucleus (APN) in a cohort of severely impaired elderly subjects with schizophrenia (SZ) relative to age matched nonpsychiatric controls (NCs). The present study was undertaken to determ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2008.08.023
更新日期：2008-12-01 00:00:00
abstract：:Using the fluorescent probe DPH (1,6-diphenyl-1,3,5-hexatriene), steady-state anisotropy (rs) values were determined in red blood cell (RBC) ghost membranes of schizophrenic patients before (n = 26) and after (n = 16) haloperidol withdrawal, and age- and sex-matched normal controls (n = 22). Patients on haloperidol we...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(94)90014-0
更新日期：1994-02-01 00:00:00
abstract：:Recent research on risk for psychosis has focused on youth who manifest subclinical signs that are often associated with the prodrome to psychosis. Standardized measures of prodromal symptoms have been shown to significantly enhance prediction of risk for conversion to an Axis I psychotic disorder. In the present stud...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2011.03.034
更新日期：2011-08-01 00:00:00
abstract：:The current study investigated whether a previously reported beneficial effect of methadone maintenance therapy (MMT) on antiretroviral adherence is also present in relation to antipsychotic treatment for schizophrenia. Administrative data were linked over a 17-year period for 1996 people who were dually diagnosed wit...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.05.031
更新日期：2019-08-01 00:00:00
abstract：:In view of prior reports suggesting associations between polymorphisms of the tumor necrosis factor gene (TNF) and schizophrenia, we sequenced all exons, introns and 7 kb flanking sequence at TNF in DNA pooled from 125 Caucasian schizophrenia cases and 200 controls. We identified 18 SNPs of which we selected and genot...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2005.12.853
更新日期：2006-03-01 00:00:00
abstract：:Recovery from psychotic disorders includes both symptomatic and functional components. Progress in understanding recovery requires careful replication and extension of findings using comparable measures. In the current paper, we present a study of five year recovery rates in an early intervention program in London, Ca...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.08.054
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:Many patients with schizophrenia suffer from metabolic symptoms and weight gain in which predispose them to obesity, diabetes, and cardiovascular problems. This trial examines the efficacy and safety of zonisamide on weight and body mass index in patients with schizophrenia being administered with atypical a...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2013.03.021
更新日期：2013-06-01 00:00:00
abstract：:Brain morphometry has been studied extensively in schizophrenic patients, and among the cortical differences identified two consistent findings are decreased cerebellar vermal volume and increased volume of the fourth ventricle; although contradictory findings are reported as well. Recent cognitive activation studies ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(98)00137-6
更新日期：1999-05-04 00:00:00
abstract：:Attention deficits are considered to be fundamental in patients with schizophrenia. During attention tasks, patients with schizophrenia have been shown to display increased brain activity in some neuroimaging studies but reduced brain activity in others. These conflicting findings may be due to some study designs prim...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2010.03.019
更新日期：2010-09-01 00:00:00
abstract：OBJECTIVE:Research participants must have adequate consent-related abilities to provide informed consent at the time of study enrollment. We sought to determine if research participants with schizophrenia maintain adequate consent-related abilities during a longitudinal study. If participants lose abilities during a tr...
journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.schres.2011.04.012
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND:Structural pathology in the hippocampus is well-documented in schizophrenia, but brain functional changes have not been consistently found. We used spatial navigation in a virtual reality environment, a task that is known to produce robust hippocampal activation in healthy subjects, to examine task-related a...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.02.033
更新日期：2016-04-01 00:00:00
abstract：:Sustained attention deficits and high rates of smoking are often observed in patients with schizophrenia. This has led to the hypothesis that patients may smoke as an attempt to ameliorate cognitive deficits related to abnormal nicotinic structure and function. Continuous performance tasks (CPT) are often used to inde...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.06.012
更新日期：2013-08-01 00:00:00
abstract：:It is now well established that the utilization of standardized clinical criteria can enhance prediction of psychosis. These criteria are primarily concerned with the presence and severity of attenuated positive symptoms. Because these symptom criteria are used to derive algorithms for designating clinical high risk (...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.schres.2015.04.035
更新日期：2015-08-01 00:00:00
abstract：INTRODUCTION:Progressive atrophy occurs in brain regions involved in the working memory network along the schizophrenia's course, but without parallel evolution of working memory impairment. We investigated the functional organization inside this network at different stages of the disease. METHODS:Twenty-eight patient...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.10.023
更新日期：2013-12-01 00:00:00
abstract：:MicroRNAs (miRNAs) are small non-coding RNAs that mainly function as negative regulators of gene expression (Lai, 2002) and have been shown to be involved in schizophrenia etiology through genetic and expression studies (Burmistrova et al., 2007; Hansen et al., 2007a; Perkins et al., 2007; Beveridge et al., 2010; Kim ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.06.038
更新日期：2012-10-01 00:00:00
abstract：:Schizoaffective disorder is a common diagnosis in clinical practice but its nosological status has been subject to debate ever since it was conceptualized. Although it is key that diagnostic reliability is sufficient, schizoaffective disorder has been reported to have low interrater reliability. Evidence based on syst...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.schres.2016.07.012
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:Delusions of control are among the most distinctive and characteristic symptoms of schizophrenia. Several theories have been proposed that implicate aberrant communication between spatially disparate brain regions in the etiology of this symptom. Given that white matter fasciculi represent the anatomical inf...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.08.033
更新日期：2015-01-01 00:00:00
abstract：:Cholesterol metabolism is vital for brain function. Previous work in cultured cells has shown that a number of psychotropic drugs inhibit the activity of 7-dehydrocholesterol reductase (DHCR7), an enzyme that catalyzes the final steps in cholesterol biosynthesis. This leads to the accumulation of 7-dehydrocholesterol ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.02.001
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:The presence of a psychosis continuum is suggested by studies showing that schizophrenia and non-clinical psychotic symptoms in the general population share the same risk factors. However, to our knowledge no large-scale studies have been conducted which examine the specificity of these risk factors in the g...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2010.03.033
更新日期：2010-07-01 00:00:00
abstract：BACKGROUND:There is evidence that schizophrenia is a neuro-immune disorder. Genes linked to intragenic LINE-1 methylation show a strong association with immune-associated disorders including psychosis. The aim of this study was to examine LINE-1 methylation patterns in paranoid schizophrenia and methamphetamine-induced...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.02.015
更新日期：2019-06-01 00:00:00
abstract：:Previous transcriptome analyses of brain samples provided several insights into the pathophysiology of schizophrenia. In this study, we aimed to re-investigate gene expression datasets from seven brain regions of patients with schizophrenia and healthy controls by adopting a unified approach. After adjustment for conf...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2020.06.032
更新日期：2020-09-01 00:00:00
abstract：:This study documents a severe picture naming impairment in a series of 22 chronically hospitalised schizophrenics. The pattern and level of naming impairment were comparable in degree and type to that seen neurological patients with left hemisphere lesions. This deficit was further examined to determine whether it con...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(99)00184-x
更新日期：2000-09-29 00:00:00
