Abstract：
BACKGROUND:The aim of this study is to determine the rate of persistent negative symptoms according to different criteria during two years of follow-up after first-episode schizophrenia. METHODS:The study sample consisted of 105 patients with first-episode schizophrenia who completed at least 12 months of follow-up period. We used 6 different definitions of persistent negative symptoms (PNS) based on the Scale for the Assessment of Negative Symptoms subscale scores at seven time points throughout the follow-up. In some definitions of PNS, patients with suprathreshold depressive symptoms were excluded. Premorbid adjustment and baseline cognitive performances of the patients were assessed. RESULTS:The PNS rates were between 14.2 and 27.9% in the first year and 11.1 and 25.8% in the second year. Seventy-eight percent of the patients who met the strictest PNS criteria during the first 12 months met the same criteria also during the second 12-month-period. Those with PNS had earlier onset, lower premorbid functioning, worse executive functioning and attention at baseline, and lower rates of working/studying during the 2-year follow-up. Duration of education and untreated psychosis are the independent variables that contribute to the PNS status at the first year of follow-up in logistic regression analysis. CONCLUSION:Our findings suggest that PNS has specific predictors and effect on the course of illness after first-episode schizophrenia.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Üçok A,Ergül Cdoi
10.1016/j.schres.2014.07.021subject
Has Abstractpub_date
2014-09-01 00:00:00pages
241-6issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(14)00378-8journal_volume
158pub_type
杂志文章abstract：:Recent molecular genetic studies have demonstrated X-chromosome abnormalities in the transmission of psychosis, a finding that may contribute to understanding sex differences in the disorder. Using our family high risk paradigm, we tested the hypothesis that there are sex-specific patterns of transmission of psychosis...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2011.01.019
更新日期：2011-05-01 00:00:00
abstract：:Abnormalities of cerebellar structure and function, long recognized as a hallmark of chronic alcohol abuse, have also occasionally been noted in patients with schizophrenia. We used a four-point rating scale to assess clinical signs of cerebellar dysfunction in men meeting DSM-IV criteria for schizophrenia (N=34) and ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(01)00300-0
更新日期：2002-10-01 00:00:00
abstract：:Previous studies suggested that African American patients with psychotic disorders receive higher doses of antipsychotic medication than white patients, are more likely to receive depot antipsychotics, and are less likely to be prescribed second-generation antipsychotics. African-American men in particular may be most...
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pub_type： 杂志文章
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更新日期：2004-02-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章
doi：10.1016/S0920-9964(03)00129-4
更新日期：2004-02-01 00:00:00
abstract：BACKGROUND:Many studies have identified urban-rural differences in the occurrence of schizophrenia. Though unknown, the underlying causes responsible for these differences have been hypothesized to include urban-rural differences in toxic exposures, diet, infections, stress, or an artifact due to selective migration. F...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.08.028
更新日期：2015-10-01 00:00:00
abstract：:Currently, little is known about the pharmacological effects of the new generation of antipsychotic medications on perception of emotion in schizophrenia. The present study was designed to compare the effects of risperidone versus haloperidol on the ability to perceive emotion in 20 treatment-resistant schizophrenia p...
journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0920-9964(98)00026-7
更新日期：1998-05-25 00:00:00
abstract：:Frontal lobe dysfunction in individuals with schizophrenia has frequently been detected using both neuroimaging and neuropsychological testing. Results from previous studies vary in the findings of regional specificity vs. generalized frontal cortical dysfunction. We sought to examine potential regional differences in...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/S0920-9964(03)00086-0
更新日期：2004-05-01 00:00:00
abstract：:There is conflicting evidence of a relationship between changes in symptoms and cognitive functioning in schizophrenia. This study investigated longitudinal changes in psychopathology and cognitive functioning in chronic schizophrenia utilising three different dimensional models of symptomatology. Sixty-two patients d...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(01)00393-0
更新日期：2003-02-01 00:00:00
abstract：:Since the recognition that adults with velocardiofacial syndrome (VCFS), which is associated with hemizygous interstitial deletions of chromosome 22q11, frequently show psychotic symptoms, deletion of the 22q11.2 region has been proposed as a common genetic abnormality associated with schizophrenia. In studies of schi...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(00)00192-4
更新日期：2001-12-01 00:00:00
abstract：:Impaired working memory (WM) function in schizophrenia has been associated with abnormal activation of the dorsolateral prefrontal cortex (DLPFC). It is, however, not clear whether abnormal activation is a sign of DLPFC pathology, or a correlate of poor performance. We address this question by examining activity in th...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/S0920-9964(03)00127-0
更新日期：2004-06-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.11.022
更新日期：2016-01-01 00:00:00
abstract：:[(3)H]ketanserin binding to 5HT(2A) receptors was measured in the left planum temporale (sensory speech cortex) from schizophrenic and non-schizophrenic (control) subjects using both particulate membranes and tissue sections. There was a significant decrease in the affinity of [(3)H]ketanserin binding to particulate m...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(99)00150-4
更新日期：2000-07-07 00:00:00
abstract：OBJECTIVE:Several risk factors of venous thromboembolism (VTE) and pulmonary embolism (PE) were found in patients with schizophrenia. Therefore, we hypothesize that the incidences of VTE and PE are relatively higher among schizophrenia patients in comparison with the general population. METHOD:For this population-base...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.01.012
更新日期：2015-03-01 00:00:00
abstract：:Glutamate transporters facilitate the buffering, clearance and cycling of glutamate and play an important role in maintaining synaptic and extrasynaptic glutamate levels. Alterations in glutamate transporter expression may lead to abnormal glutamate neurotransmission contributing to the pathophysiology of schizophreni...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.12.019
更新日期：2013-03-01 00:00:00
abstract：:Natural killer cell activity was prospectively studied in 15 patients with chronic schizophrenia and in seven patients with schizoaffective disorder, depressed type. These patients were compared to individually matched normal controls. No mean differences in natural killer cell activity between the patient groups and ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(92)90028-4
更新日期：1992-12-01 00:00:00
abstract：:Levels of the histamine metabolites, tele-methylhistamine (t-MH) and tele-methylimidazoleacetic acid (t-MIAA), and metabolites of other aminergic transmitters and of norepinephrine were measured in cerebrospinal fluid of 36 inpatients with chronic schizophrenia and eight controls. The mean t-MH level from controls was...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(94)00034-6
更新日期：1995-01-01 00:00:00
abstract：:The Scales of Cognitive Impairment Rated From Institutional Records (SCIRFIR), a battery based on commonly used dementia rating instruments, was tested on the records of 26 chronically institutionalized, elderly schizophrenia patients, for the purpose of retrospectively evaluating the long-term course of cognitive cha...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(98)00086-3
更新日期：1999-01-11 00:00:00
abstract：OBJECTIVE:Young adults with early phase schizophrenia often report a past or current pattern of illicit substance use and/or alcohol misuse. Still, little is known about the cumulative and separate effects of each stressor on white matter tissue, at this vulnerable period of brain development. METHODS:Participants inv...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.04.022
更新日期：2016-08-01 00:00:00
abstract：UNLABELLED:One important risk factor for cardiovascular disease is the metabolic syndrome (MS), yet limited data exist on its prevalence in US patients with schizophrenia. METHODS:Using baseline data from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Schizophrenia Trial, assessment of MS prev...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2005.07.014
更新日期：2005-12-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析
doi：10.1016/j.schres.2013.12.003
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:The recovery movement is having a growing impact on policy for people with severe mental illness. The empirical literature on the recovery orientation, however, is scant, and no empirical conceptualization of recovery has been published. METHOD:We identified items reflecting recovery themes and measuring asp...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2004.05.009
更新日期：2005-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0920-9964(01)00405-4
更新日期：2003-02-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/s0920-9964(00)00022-0
更新日期：2001-01-15 00:00:00
abstract：:Apolipoprotein D (apoD) is a member of the lipocalin superfamily of transporter proteins that bind small hydrophobic molecules, including arachidonic acid (AA). The ability of apoD to bind AA implicates it in pathways associated with membrane phospholipid signal transduction and metabolism. Recent findings of an incre...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2004.05.007
更新日期：2005-01-01 00:00:00
abstract：:We employed a simple and relatively undemanding task of monotone counting for the assessment of sustained attention in schizophrenic patients. The monotone counting task has been validated neuropsychologically and is particularly sensitive to right prefrontal lesions. We compared the performance of schizophrenic patie...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(96)00120-x
更新日期：1997-04-11 00:00:00
abstract：:Studies of neurocognitive function in patients with schizophrenia use widely variable assessment techniques. Clinical trials assessing the cognitive enhancing effect of new medications have used neurocognitive assessment batteries that differed in content, length and administration procedures. The Brief Assessment of ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2003.09.011
更新日期：2004-06-01 00:00:00
abstract：:The goal of this study was to determine if family burden experienced by the families of individuals with a recent-onset of schizophrenia is associated with whether the individual is able to work or attend school during the first year of treatment. Forty-one participants with a recent first episode of schizophrenia and...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.06.068
更新日期：2018-12-01 00:00:00
abstract：:Affective impairments were examined in patients with and without deficit syndrome schizophrenia. Two Emotional Stroop tasks designed to measure automatic processing of emotional information were administered to deficit (n=15) and non-deficit syndrome (n=26) schizophrenia patients classified according to the Schedule f...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2008.01.014
更新日期：2008-07-01 00:00:00
abstract：BACKGROUND:Deficient mirror neuron system (MNS)-activity is associated with social cognition deficits in schizophrenia. However, it is not known how socio-emotional contexts modulate the MNS-response. In a Transcranial Magnetic Stimulation (TMS)-experiment, we aimed to compare putative MNS-responses to action observati...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.07.043
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:Recent empirical evidence [Maher, B.A., Manschreck, T.C., Linnert, J., Candela, S., 2005. Quantitative assessment of the frequency of normal associations in the utterances of schizophrenia patients and healthy controls. Schizophrenia Research 78, 219-224] shows that schizophrenia patients produce an elevated...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.06.009
更新日期：2007-09-01 00:00:00
