Sex-specific rates of transmission of psychosis in the New England high-risk family study.


:Recent molecular genetic studies have demonstrated X-chromosome abnormalities in the transmission of psychosis, a finding that may contribute to understanding sex differences in the disorder. Using our family high risk paradigm, we tested the hypothesis that there are sex-specific patterns of transmission of psychosis and whether there is specificity comparing nonaffective- with affective-type psychoses. We identified 159 parents with psychoses (schizophrenia psychosis spectrum disorders (SPS, n=59) and affective (AP, n=100)) and 114 comparable, healthy control parents. 203 high risk (HR) and 147 control offspring were diagnostically assessed (185 females; 165 males). We compared the proportion of male:female offspring with psychoses by affected parent sex and the consistency for SPS compared to AP parents, and tested (using exact logistic regression) whether the male:female ratio for affected offspring differed significantly between affected mothers and affected fathers. Risk of psychosis in offspring was a function of the sex of the parent and offspring. Among ill mothers, 18.8% of their male offspring developed psychosis compared with 9.5% of their daughters. In contrast, among ill fathers, 3.1% of their male offspring developed psychosis compared with 15.2% of their daughters. The male:female ratio for affected offspring differed significantly (p < 0.05) between affected mothers and fathers. Similar patterns held for SPS and AP. Results demonstrated sex-specific transmission of psychosis regardless of psychosis-type and suggest X-linked inheritance. This has important implications for molecular genetic studies of psychoses underscoring the impact of one's gender on gene-brain-behavior phenotypes of SCZ.


Schizophr Res


Schizophrenia research


Goldstein JM,Cherkerzian S,Seidman LJ,Petryshen TL,Fitzmaurice G,Tsuang MT,Buka SL




Has Abstract


2011-05-01 00:00:00














  • Dual diagnosis of substance abuse in schizophrenia: prevalence and impact on outcomes.

    abstract::Comorbid substance abuse disorders have emerged as one of the greatest obstacles to the effective treatment of persons with schizophrenia. Estimates of the prevalence of such comorbidity vary, but as many as half of persons with schizophrenia may suffer from a comorbid drug or alcohol disorder. Younger age, male gende...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,评审


    authors: Dixon L

    更新日期:1999-03-01 00:00:00

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    abstract:BACKGROUND:A false sense of reality is a characteristic of schizophrenia spectrum disorders (SSD). Reality confusion may also emanate from posterior orbitofrontal cortex (OFC) lesions, as evident in confabulations that patients act upon and disorientation. This confusion can be measured by repeated runs of a continuous...

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    authors: Thézé R,Manuel AL,Pedrazzini E,Chantraine F,Patru MC,Nahum L,Guggisberg AG,Schnider A

    更新日期:2019-02-01 00:00:00

  • Opposite changes in predominantly docosahexaenoic acid (DHA) in cerebrospinal fluid and red blood cells from never-medicated first-episode psychotic patients.

    abstract::Variable levels of essential polyunsaturated fatty acids (EPUFAs) reported in schizophrenia are likely due to differences in age, sex, ethnicity, diet, life style and treatments. The present study examined the EPUFAs levels in plasma, RBC and CSF in never-medicated first-episode psychotic patients and normal controls ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,多中心研究


    authors: Kale A,Joshi S,Naphade N,Sapkale S,Raju MS,Pillai A,Nasrallah H,Mahadik SP

    更新日期:2008-01-01 00:00:00

  • Paranoid schizophrenia and methamphetamine-induced paranoia are both characterized by a similar LINE-1 partial methylation profile, which is more pronounced in paranoid schizophrenia.

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    pub_type: 杂志文章


    authors: Kalayasiri R,Kraijak K,Mutirangura A,Maes M

    更新日期:2019-06-01 00:00:00

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    authors: Freedman R,Waldo M,Bickford-Wimer P,Nagamoto H

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    authors: Kansal V,Patriciu I,Kiang M

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    authors: Lee SC,DelPozo-Banos M,Lloyd K,Jones I,Walters JTR,Owen MJ,O'Donovan M,John A

    更新日期:2020-06-01 00:00:00

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    更新日期:2020-07-02 00:00:00

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    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Bao Y,Ibram G,Blaner WS,Quesenberry CP,Shen L,McKeague IW,Schaefer CA,Susser ES,Brown AS

    更新日期:2012-05-01 00:00:00

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    pub_type: 杂志文章


    authors: Hughes C,Kumari V,Soni W,Das M,Binneman B,Drozd S,O'Neil S,Mathew V,Sharma T

    更新日期:2003-02-01 00:00:00

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    pub_type: 信件


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    更新日期:2015-10-01 00:00:00

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    authors: Guo X,Li J,Wang J,Fan X,Hu M,Shen Y,Chen H,Zhao J

    更新日期:2014-02-01 00:00:00

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    pub_type: 杂志文章


    authors: Stephane M,Thuras P,Nasrallah H,Georgopoulos AP

    更新日期:2003-06-01 00:00:00

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    pub_type: 杂志文章


    authors: Bates AT,Kiehl KA,Laurens KR,Liddle PF

    更新日期:2009-12-01 00:00:00

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    authors: Combs DR,Chapman D,Waguspack J,Basso MR,Penn DL

    更新日期:2011-04-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:2008-09-01 00:00:00

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    pub_type: 杂志文章,随机对照试验


    authors: Ghanizadeh A,Nikseresht MS,Sahraian A

    更新日期:2013-06-01 00:00:00

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    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Kelleher I,Wigman JT,Harley M,O'Hanlon E,Coughlan H,Rawdon C,Murphy J,Power E,Higgins NM,Cannon M

    更新日期:2015-06-01 00:00:00

  • Excess medical comorbidity and mortality across the lifespan in schizophrenia.: A nationwide Danish register study.

    abstract:INTRODUCTION:People with severe mental illness have greater risk of un-detected and inadequately treated medical disorders, adding up to the risk of premature death. This study investigated how chronic medical comorbidity evolved across the lifespan in schizophrenia and the associated impact on mortality. METHOD:A reg...

    journal_title:Schizophrenia research

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    authors: Brink M,Green A,Bojesen AB,Lamberti JS,Conwell Y,Andersen K

    更新日期:2019-04-01 00:00:00

  • Neurological soft signs in psychometrically identified schizotypy.

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    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Kaczorowski JA,Barrantes-Vidal N,Kwapil TR

    更新日期:2009-12-01 00:00:00

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    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Scheller-Gilkey G,Moynes K,Cooper I,Kant C,Miller AH

    更新日期:2004-08-01 00:00:00

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    abstract::A growing body of evidence suggests that abnormal elements of the cytoskeleton may be associated with the pathophysiology of schizophrenia. Isoforms of a major cytoskeleton protein, β-tubulin, were recently demonstrated to have distinct roles in neuronal differentiation and cell viability. For these reasons, we tested...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Moehle MS,Luduena RF,Haroutunian V,Meador-Woodruff JH,McCullumsmith RE

    更新日期:2012-03-01 00:00:00

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    abstract:BACKGROUND:Childhood and adolescence represent the periods during which hallucinatory experiences occur at the greatest prevalence, and also constitute a critical window of vulnerability for the pathogenesis of psychotic disorders. The longitudinal course of hallucinatory experiences during late childhood and adolescen...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,评审


    authors: Rubio JM,Sanjuán J,Flórez-Salamanca L,Cuesta MJ

    更新日期:2012-07-01 00:00:00

  • Factors associated with violence among Japanese patients with schizophrenia prior to psychiatric emergency hospitalization: a case-controlled study.

    abstract:BACKGROUND:Numerous studies have examined a wide range of risk factors associated with violence among patients with schizophrenia. However, risk factors linked to different socio-cultural backgrounds remain unclear. OBJECTIVE:The objectives were to investigate factors associated with violence among Japanese patients w...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Imai A,Hayashi N,Shiina A,Sakikawa N,Igarashi Y

    更新日期:2014-12-01 00:00:00

  • Deficient multisensory integration in schizophrenia: an event-related potential study.

    abstract:BACKGROUND:In many natural audiovisual events (e.g., the sight of a face articulating the syllable /ba/), the visual signal precedes the sound and thus allows observers to predict the onset and the content of the sound. In healthy adults, the N1 component of the event-related brain potential (ERP), reflecting neural ac...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Stekelenburg JJ,Maes JP,Van Gool AR,Sitskoorn M,Vroomen J

    更新日期:2013-07-01 00:00:00

  • Workshop on defining the significance of progressive brain change in schizophrenia: December 12, 2008 American College of Neuropsychopharmacology (ACNP) all-day satellite, Scottsdale, Arizona. The rapporteurs' report.

    abstract::In 1990 a satellite session of the American College of Neuropsychopharmacology (ACNP) Annual Meeting was held that focused on the question of whether progressive changes in brain structure occur in schizophrenia and this session raised considerable controversy. Eighteen years later, on December 12, 2008, after much da...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Borgwardt SJ,Dickey C,Hulshoff Pol H,Whitford TJ,DeLisi LE

    更新日期:2009-07-01 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Cather C,Penn D,Otto MW,Yovel I,Mueser KT,Goff DC

    更新日期:2005-05-01 00:00:00

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    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Pralong D,Tomaskovic-Crook E,Opeskin K,Copolov D,Dean B

    更新日期:2000-07-07 00:00:00

  • Decreased expression of a 40-kDa catecholamine-regulated protein in the ventral striatum of schizophrenic brain specimens from the Stanley Foundation Neuropathology Consortium.

    abstract::The majority of heat shock proteins (HSP) act as molecular chaperones protecting cells from deleterious stress. These proteins are able to inhibit the aggregation of partially denatured proteins and refold them into the correct conformation. They have also been shown to be involved in the pathogenesis of many neurodeg...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Gabriele JP,Chong VZ,Pontoriero GF,Mishra RK

    更新日期:2005-04-01 00:00:00

  • Potential stigma associated with inclusion of the psychosis risk syndrome in the DSM-V: an empirical question.

    abstract::While the "clinical high-risk state" for psychosis has demonstrated good reliability and fair predictive validity for psychotic disorders, over 50% of identified subjects do not progress to psychosis. Despite the benefits that early detection and treatment might offer, debate concerning the official inclusion of a "ps...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Yang LH,Wonpat-Borja AJ,Opler MG,Corcoran CM

    更新日期:2010-07-01 00:00:00