Sex-specific rates of transmission of psychosis in the New England high-risk family study.


:Recent molecular genetic studies have demonstrated X-chromosome abnormalities in the transmission of psychosis, a finding that may contribute to understanding sex differences in the disorder. Using our family high risk paradigm, we tested the hypothesis that there are sex-specific patterns of transmission of psychosis and whether there is specificity comparing nonaffective- with affective-type psychoses. We identified 159 parents with psychoses (schizophrenia psychosis spectrum disorders (SPS, n=59) and affective (AP, n=100)) and 114 comparable, healthy control parents. 203 high risk (HR) and 147 control offspring were diagnostically assessed (185 females; 165 males). We compared the proportion of male:female offspring with psychoses by affected parent sex and the consistency for SPS compared to AP parents, and tested (using exact logistic regression) whether the male:female ratio for affected offspring differed significantly between affected mothers and affected fathers. Risk of psychosis in offspring was a function of the sex of the parent and offspring. Among ill mothers, 18.8% of their male offspring developed psychosis compared with 9.5% of their daughters. In contrast, among ill fathers, 3.1% of their male offspring developed psychosis compared with 15.2% of their daughters. The male:female ratio for affected offspring differed significantly (p < 0.05) between affected mothers and fathers. Similar patterns held for SPS and AP. Results demonstrated sex-specific transmission of psychosis regardless of psychosis-type and suggest X-linked inheritance. This has important implications for molecular genetic studies of psychoses underscoring the impact of one's gender on gene-brain-behavior phenotypes of SCZ.


Schizophr Res


Schizophrenia research


Goldstein JM,Cherkerzian S,Seidman LJ,Petryshen TL,Fitzmaurice G,Tsuang MT,Buka SL




Has Abstract


2011-05-01 00:00:00














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    abstract::Around 1 in 5 children under 13 years old experience sub-clinical psychotic experiences (PEs) like hallucinations and delusions. While PEs in childhood are a significant risk factor for adult psychotic disorders, the majority of those experiencing childhood PEs do not develop a psychotic disorder. Individual differenc...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Dooley N,O'Hanlon E,Healy C,Adair A,McCandless C,Coppinger D,Kelleher I,Clarke M,Leemans A,Frodl T,Cannon M

    更新日期:2020-01-01 00:00:00

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    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Sunwoo M,O'Connell J,Brown E,Lin A,Wood SJ,McGorry P,O'Donoghue B

    更新日期:2020-02-01 00:00:00

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    abstract:BACKGROUND:While structural brain imaging abnormalities have been identified in schizophrenia and related disorders, it is unclear when they arise. Some appear to predate the illness and may be genetic in origin, while others are associated with the onset of the disorder. METHODS:We examined the hippocampal volumes an...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Wood SJ,Yücel M,Velakoulis D,Phillips LJ,Yung AR,Brewer W,McGorry PD,Pantelis C

    更新日期:2005-06-15 00:00:00

  • Evidence for schizophrenia susceptibility alleles in the Indian population: An association of neurodevelopmental genes in case-control and familial samples.

    abstract::Schizophrenia is a severe psychiatric disorder with lifetime prevalence of ~1% worldwide. A genotyping study was conducted using a custom panel of Illumina 1536 SNPs in 840 schizophrenia cases and 876 controls (351 patients and 385 controls from North India; and 436 patients, 401 controls and 143 familial samples with...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,meta分析


    authors: Jajodia A,Kaur H,Kumari K,Gupta M,Baghel R,Srivastava A,Sood M,Chadda RK,Jain S,Kukreti R

    更新日期:2015-03-01 00:00:00

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    abstract::Schizophrenia has generally been viewed as having a unique preschizophrenia personality or destructive to the personality post-onset. This view is reflected in the scarcity of studies of personality in schizophrenia with the exception of schizotypal personality considered by many as an endophenotype of schizophrenia. ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Lewine R,Martin M,Hart M

    更新日期:2017-11-01 00:00:00

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    journal_title:Schizophrenia research

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    authors: Hunt GE,Bergen J,Bashir M

    更新日期:2002-04-01 00:00:00

  • Weight gain with clozapine: 8-year cohort naturalistic study among hospitalized Chinese schizophrenia patients.

    abstract:OBJECTIVE:Clozapine is associated with significant weight gain. However, it is still debatable whether the majority of weight gain occurs in the early phase of treatment or if weight gain is a persistent side effect. The inconsistent results in previous outpatient studies may be due to many confounding factors, such as...

    journal_title:Schizophrenia research

    pub_type: 临床试验,杂志文章


    authors: Bai YM,Chen JY,Chen TT,Lin CY,Chou P,Su TP,Lin CC

    更新日期:2009-03-01 00:00:00

  • Social competence in schizoaffective disorder, bipolar disorder, and negative and non-negative schizophrenia.

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    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Bellack AS,Morrison RL,Mueser KT,Wade J

    更新日期:1989-07-01 00:00:00

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    journal_title:Schizophrenia research

    pub_type: 杂志文章,meta分析,评审


    authors: Greenhalgh AM,Gonzalez-Blanco L,Garcia-Rizo C,Fernandez-Egea E,Miller B,Arroyo MB,Kirkpatrick B

    更新日期:2017-01-01 00:00:00

  • Cortical thinning and caudate abnormalities in first episode psychosis and their association with clinical outcome.

    abstract::First episode psychosis (FEP) has been associated with structural brain changes, largely identified by volumetric analyses. Advances in neuroimaging processing have made it possible to measure geometric properties that may identify subtle structural changes not appreciated by a measure of volume alone. In this study w...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Scanlon C,Anderson-Schmidt H,Kilmartin L,McInerney S,Kenney J,McFarland J,Waldron M,Ambati S,Fullard A,Logan S,Hallahan B,Barker GJ,Elliott MA,McCarthy P,Cannon DM,McDonald C

    更新日期:2014-10-01 00:00:00

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    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Valmaggia LR,Day FL,Kroll J,Laing J,Byrne M,Fusar-Poli P,McGuire P

    更新日期:2015-10-01 00:00:00

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    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: McCollum LA,Roberts RC

    更新日期:2015-12-01 00:00:00

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    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Loughland CM,Williams LM,Harris AW

    更新日期:2004-03-01 00:00:00

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    journal_title:Schizophrenia research

    pub_type: 杂志文章,多中心研究,随机对照试验


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    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Cascella NG,Gerner GJ,Fieldstone SC,Sawa A,Schretlen DJ

    更新日期:2011-12-01 00:00:00

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    abstract::Low birth weight and preterm birth are important predictors of infant mortality and morbidity, and may increase the risk of schizophrenia. These adverse outcomes of pregnancy could be associated, therefore, with increased risk in children genetically predisposed to schizophrenia. The aim of this review was to describe...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,评审


    authors: Bennedsen BE

    更新日期:1998-09-07 00:00:00

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    abstract::A number of recent studies have suggested that schizophrenia patients share metamemory deficits, particularly, a decreased ability to distinguish between errors and correct responses in terms of response confidence (i.e., decreased confidence gap): patients are over-confident in errors while at the same time being und...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Moritz S,Woodward TS,Chen E

    更新日期:2006-01-31 00:00:00

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    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Dinzeo TJ,Cohen AS,Nienow TM,Docherty NM

    更新日期:2004-11-01 00:00:00

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    abstract::The Scales of Cognitive Impairment Rated From Institutional Records (SCIRFIR), a battery based on commonly used dementia rating instruments, was tested on the records of 26 chronically institutionalized, elderly schizophrenia patients, for the purpose of retrospectively evaluating the long-term course of cognitive cha...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Ortakov V,Mancevski B,Keilp J,Oppenheim S,Dwork AJ

    更新日期:1999-01-11 00:00:00

  • Altered CSNK1E, FABP4 and NEFH protein levels in the dorsolateral prefrontal cortex in schizophrenia.

    abstract::Schizophrenia constitutes a complex disease. Negative and cognitive symptoms are enduring and debilitating components of the disorder, highly associated to disability and burden. Disrupted neurotransmission circuits in dorsolateral prefrontal cortex (DLPFC) have been related to these symptoms. To identify candidates a...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Pinacho R,Villalmanzo N,Meana JJ,Ferrer I,Berengueras A,Haro JM,Villén J,Ramos B

    更新日期:2016-11-01 00:00:00

  • Deficits of spatial working memory in chronic schizophrenia.

    abstract::This study tests the hypothesis that deficits of spatial working memory are an inherent trait in schizophrenic patients, regardless of their clinical status. The participants were 22 chronic schizophrenic patients, 11 schizophrenic patients in remission, and 22 normal adults. All participants were asked to track the o...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Okada A

    更新日期:2002-01-01 00:00:00

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    journal_title:Schizophrenia research

    pub_type: 临床试验,杂志文章


    authors: Lambert M,Naber D,Karow A,Huber CG,Köhler J,Heymann J,Schimmelmann BG

    更新日期:2009-05-01 00:00:00

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    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Kim JH,Kim JH,Son YD,Joo YH,Lee SY,Kim HK,Woo MK

    更新日期:2017-04-01 00:00:00

  • Illness versus substance use effects on the frontal white matter in early phase schizophrenia: A 4Tesla (1)H-MRS study.

    abstract:OBJECTIVE:Young adults with early phase schizophrenia often report a past or current pattern of illicit substance use and/or alcohol misuse. Still, little is known about the cumulative and separate effects of each stressor on white matter tissue, at this vulnerable period of brain development. METHODS:Participants inv...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Bernier D,Bartha R,McAllindon D,Hanstock CC,Marchand Y,Dillen KNH,Gallant M,Good KP,Tibbo PG

    更新日期:2016-08-01 00:00:00

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    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Neill E,Rossell SL

    更新日期:2013-10-01 00:00:00

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    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Hengartner MP,Heekeren K,Dvorsky D,Walitza S,Rössler W,Theodoridou A

    更新日期:2017-11-01 00:00:00

  • The effect of zonisamide on antipsychotic-associated weight gain in patients with schizophrenia: a randomized, double-blind, placebo-controlled clinical trial.

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    journal_title:Schizophrenia research

    pub_type: 杂志文章,随机对照试验


    authors: Ghanizadeh A,Nikseresht MS,Sahraian A

    更新日期:2013-06-01 00:00:00

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    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Chang WH,Lin SK,Juang DJ,Chen LC,Yang CH,Hu WH,Chien CP,Lam YW,Jann MW

    更新日期:1993-03-01 00:00:00

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    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Muñoz-Negro JE,Ibanez-Casas I,de Portugal E,Ochoa S,Dolz M,Haro JM,Ruiz-Veguilla M,de Dios Luna Del Castillo J,Cervilla JA

    更新日期:2015-12-01 00:00:00

  • Screening for negative symptoms: preliminary results from the self-report version of the Clinical Assessment Interview for Negative Symptoms.

    abstract::Though negative symptoms in schizophrenia are associated with a host of deleterious outcomes (e.g., White et al., 2009), not all individuals with schizophrenia suffer from negative symptoms (e.g., Blanchard et al., 2005). Thus, methods to quickly screen and identify patients for more intensive clinical interview asses...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Park SG,Llerena K,McCarthy JM,Couture SM,Bennett ME,Blanchard JJ

    更新日期:2012-03-01 00:00:00