Abstract：
BACKGROUND:Cannabis and cocaine are the most common illicit drugs for which people are treated in addiction services in Latin America. Much research has suggested that the use of cannabis increases the risk of schizophrenia; there is less evidence concerning cocaine. The aim of the present study was to establish the relative prevalence of schizophrenia in people treated for cannabis use and cocaine use disorders in Chile. METHODS:A sample of 22,615 people treated for illicit drug use disorders was obtained from a national registry of addiction service users in Chile. Clinical diagnoses were established at admission to substance use treatment programs or at any point during the period of treatment. Prevalence rates of schizophrenia and related disorders, and affective disorders were calculated for the groups of people with cocaine use disorders, and cannabis use disorders. Odds ratios (OR) for schizophrenia and for affective disorders were calculated for cannabis users using the group of people treated for cocaine use disorders as reference category. RESULTS:The prevalence of schizophrenia and related disorders was 1.1% in those with cocaine use disorders, but 5.2% in those with cannabis use disorders (OR 4.9; p<0.01). The prevalence of affective disorders was 9.3% in cocaine use disorders, and 13.2% in cannabis use disorders (OR 1.5; p<0.01). CONCLUSIONS:The prevalence of schizophrenia and to a lesser extent affective disorders is higher among people with cannabis use disorder than cocaine use disorder among those attending addiction services.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Libuy N,de Angel V,Ibáñez C,Murray RM,Mundt APdoi
10.1016/j.schres.2017.04.010subject
Has Abstractpub_date
2018-04-01 00:00:00pages
13-17eissn
0920-9964issn
1573-2509pii
S0920-9964(17)30197-4journal_volume
194pub_type
杂志文章abstract：:Schizophrenia is a severe psychiatric disorder with lifetime prevalence of ~1% worldwide. A genotyping study was conducted using a custom panel of Illumina 1536 SNPs in 840 schizophrenia cases and 876 controls (351 patients and 385 controls from North India; and 436 patients, 401 controls and 143 familial samples with...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析
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更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:Eye movement abnormalities have been identified in schizophrenia; however, their relevance to cognition is still unknown. In this study, we explored the general relationship between eye movements and cognitive function. METHODS:The three eye movement measures (scanpath length, horizontal position gain, and ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.12.051
更新日期：2019-07-01 00:00:00
abstract：:There is strong evidence that hippocampal 5-hydroxytryptamine (5-HT) systems are affected in schizophrenia and hence we have studied a number of markers of the 5-HT system in hippocampi from subjects with schizophrenia. Using in situ radioligand binding with autoradiography we measured [(3)H]proplyamino-8-hydroxy-1,2,...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2004.02.007
更新日期：2004-12-01 00:00:00
abstract：:We developed and validated a self-administered questionnaire (Subjective Quality of Life Analysis, S.QUA.L.A.) to measure subjective quality of life. S.QUA.L.A. is a multidimensional instrument. This scale includes 22 domains of life. It covers traditional areas (food, family relation etc)., and more abstract aspects ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2004.09.017
更新日期：2005-07-01 00:00:00
abstract：OBJECTIVE:We examined the relationship between cerebral gray matter (GM) volume and severity of delusions and hallucinations in adults with schizophrenia. METHOD:MRI scans in 43 patients with schizophrenia were acquired. Correlations were computed between GM volume and clinician ratings of hallucinations and delusions...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2011.08.004
更新日期：2011-12-01 00:00:00
abstract：:The watershed-hypothesis of schizophrenia asserts that over 200 different mutations dysregulate distinct pathways that converge on an unspecified common mechanism(s) that controls disease ontogeny. Consistent with this hypothesis, our RNA-sequencing of neuron committed cells (NCCs) differentiated from established iPSC...
journal_title：Schizophrenia research
pub_type： 杂志文章
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abstract：:The involvement of the gamma-aminobutyric acid (GABA) system in schizophrenia is suggested by postmortem studies and the common use of GABA receptor-potentiating agents in treatment. In a recent study, we used a benzodiazepine challenge to demonstrate abnormal GABAergic function during processing of negative visual st...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.08.022
更新日期：2015-10-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.10.011
更新日期：2012-12-01 00:00:00
abstract：:repetitive thinking is often increased in various psychopathological conditions. However, evidence for its possible contribution to psychotic symptoms relies only on correlational analysis and has not been experimentally tested within the psychotic continuum. This research aims to examine whether repetitive thinking a...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.04.007
更新日期：2018-03-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究
doi：10.1016/s0920-9964(01)00318-8
更新日期：2002-10-01 00:00:00
abstract：:Grey matter brain networks are disrupted in schizophrenia, but it is still unclear at which point during the development of the illness these disruptions arise and whether these can be associated with behavioural predictors of schizophrenia. We investigated if single-subject grey matter networks were disrupted in a sa...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.08.025
更新日期：2015-10-01 00:00:00
abstract：:Brain abnormalities have been identified in patients with schizophrenia, but what is unclear is whether these changes are progressive over the course of the disorder. In this longitudinal study, hippocampal and temporal lobe volumes were measured at two time points in 30 patients with first episode psychosis (mean fol...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(01)00175-x
更新日期：2001-10-01 00:00:00
abstract：BACKGROUND:Older paternal age predicts schizophrenia diagnosis in offspring. If this relationship reflects a pathogenic process, paternal age should predict the expression of subclinical schizophrenia liability (schizotypy). We hypothesized that paternal and maternal ages predict positive, negative, and disorganized fe...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.09.018
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:Suicide and violence often co-occur in the general population as well as in mentally ill individuals. Few studies, however, have assessed whether these suicidal behaviors are predictive of violence risk in mental illness. AIMS:The aim of this study is to investigate whether suicidal behaviors, including sui...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.02.001
更新日期：2014-04-01 00:00:00
abstract：:The aim of the present study is to explore the relationship between depression and psychotic symptoms of schizophrenia over the course of illness. Sixty-eight patients meeting DSM-IV criteria for schizophrenia were enrolled, 27 in an acute episode, 41 when stable. Assessments were performed using the Calgary Depressio...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(00)00002-5
更新日期：2001-03-01 00:00:00
abstract：OBJECTIVE:The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Project produced a battery of tests, the MATRICS Consensus Cognitive Battery (MCCB), designed to assess cognitive treatment effects in clinical trials of patients with schizophrenia. In validation studies, the MCCB demonstr...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.schres.2010.09.015
更新日期：2011-02-01 00:00:00
abstract：:Schizophrenia constitutes a complex disease. Negative and cognitive symptoms are enduring and debilitating components of the disorder, highly associated to disability and burden. Disrupted neurotransmission circuits in dorsolateral prefrontal cortex (DLPFC) have been related to these symptoms. To identify candidates a...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.04.050
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:There is increased interest in the impact of new long-acting treatments on health-related quality of life (HRQoL) in patients with schizophrenia. The aim of this study was to evaluate the impact of treatment with subcutaneous injections of RBP-7000, a new sustained-release formulation of risperidone, compare...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.schres.2016.03.020
更新日期：2016-07-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(00)00062-1
更新日期：2001-03-01 00:00:00
abstract：:Our aim was to investigate the association between parental psychosis and potential risk factors for schizophrenia and their interaction. We evaluated whether the factors during pregnancy and birth have a different effect among subjects with and without a history of parental psychosis and whether parental psychosis ma...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.12.033
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND:Recovery is the ultimate goal of psychosis treatment. Basic self-disturbances (BSDs) are non-psychotic phenomena associated with clinical outcome, present in prodromal, psychotic and residual phases of psychotic disorders. AIM:To investigate the relationship between BSDs and recovery seven years after first...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.08.009
更新日期：2019-10-01 00:00:00
abstract：:The current study examined the factor structure of the Brief Negative Symptom Scale (BNSS), a next-generation negative symptom rating instrument developed in response to the NIMH-sponsored Consensus Development Conference on Negative Symptoms. Participants included 146 individuals with a DSM-IV diagnosis of schizophre...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.09.007
更新日期：2012-12-01 00:00:00
abstract：PURPOSE:To identify the determinants of schizophrenia-specific HRQoL levels, five types of factors (i.e., sociodemographic, clinical, psychopathological, neurocognitive, and psychosocial factors) were simultaneously investigated in the same cross-sectional sample. METHODS:A total of 120 patients with a diagnosis of sc...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.02.011
更新日期：2014-04-01 00:00:00
abstract：:Autism and schizophrenia share multiple phenotypic and genotypic markers, and there is ongoing debate regarding the relationship of these two disorders. To examine whether cortical dynamics are similar across these disorders, we directly compared fMRI responses to visual, somatosensory and auditory stimuli in adults w...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.03.036
更新日期：2016-08-01 00:00:00
abstract：:In 1873 Skeffington Lutwidge, a Lunacy Commission inspector of asylums in England, was killed by an asylum patient. Lutwidge was the uncle and close friend of Charles Lutwidge Dodgson, also known as Lewis Carroll. One year later, Carroll began writing The Hunting of the Snark, a poem whose meaning has mystified Carrol...
journal_title：Schizophrenia research
pub_type： 传,历史文章,杂志文章
doi：10.1016/j.schres.2014.10.001
更新日期：2014-12-01 00:00:00
abstract：:Research on the effectiveness of treatment programs in early stages of severe mental illness raise significant ethical questions when conducted in industrialized countries that have adequate protections for the human subjects of biomedical and behavioral research. Before embarking on similar trials in developing count...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(01)00244-4
更新日期：2001-08-01 00:00:00
abstract：BACKGROUND:Our previous lipidomics studies demonstrated elevated sulfatides, plasmalogens, and N-acylphosphatidylserines in the frontal cortex of schizophrenia subjects. These data suggest that there may be an abnormal function of glycosynapses in schizophrenia. We further examined the disease and anatomical specificit...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.05.017
更新日期：2015-08-01 00:00:00
abstract：:The guarantee of perceptual coherence for events through everyday life situations depends upon the capacity to correctly integrate series of multi-sensory experiences. Patients with schizophrenia have been shown to reveal a deficit in integrating, i.e., "binding", perceptual information together. However, results in t...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.08.013
更新日期：2007-12-01 00:00:00
abstract：:Schizophrenia is associated with significant impairments in both higher and lower order social cognitive performance and these impairments contribute to poor social functioning. People with schizophrenia report poor social functioning to be one of their greatest unmet treatment needs. Recent studies have suggested the...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2015.06.005
更新日期：2015-11-01 00:00:00
abstract：:Patients with schizophrenia exhibit impairments in prepulse inhibition (PPI) of the startle response. Available data suggest that atypical antipsychotics may be more effective than typical antipsychotics in improving PPI deficits in schizophrenia. However, previous studies have used between-subjects rather than longit...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.09.035
更新日期：2009-12-01 00:00:00
