Abstract:
:Schizophrenia constitutes a complex disease. Negative and cognitive symptoms are enduring and debilitating components of the disorder, highly associated to disability and burden. Disrupted neurotransmission circuits in dorsolateral prefrontal cortex (DLPFC) have been related to these symptoms. To identify candidates altered in schizophrenia, we performed a pilot proteomic analysis on postmortem human DLPFC tissue from patients with schizophrenia (n=4) and control (n=4) subjects in a pool design using differential isotope peptide labelling followed by liquid chromatography tandem mass spectrometry (LC-MS/MS). We quantified 1315 proteins with two or more unique peptides, 116 of which showed altered changes. Of these altered proteins, we selected four with potential roles on cell signaling, neuronal development and synapse functioning for further validation: casein kinase I isoform epsilon (CSNK1E), fatty acid-binding protein 4 (FABP4), neurofilament triplet H protein (NEFH), and retinal dehydrogenase 1 (ALDH1A1). Immunoblot validation confirmed our proteomic findings of these proteins being decreased in abundance in the schizophrenia samples. Additionally, we conducted immunoblot validation of these candidates on an independent sample cohort comprising 23 patients with chronic schizophrenia and 23 matched controls. In this second cohort, CSNK1E, FABP4 and NEFH were reduced in the schizophrenia group while ALDH1A1 did not significantly change. This study provides evidence indicating these proteins are decreased in schizophrenia: CSNK1E, involved in circadian molecular clock signaling, FABP4 with possible implication in synapse functioning, and NEFH, important for cytoarchitecture organization. Hence, these findings suggest the possible implication of these proteins in the cognitive and/or negative symptoms in schizophrenia.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Pinacho R,Villalmanzo N,Meana JJ,Ferrer I,Berengueras A,Haro JM,Villén J,Ramos Bdoi
10.1016/j.schres.2016.04.050subject
Has Abstractpub_date
2016-11-01 00:00:00pages
88-97issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(16)30220-1journal_volume
177pub_type
杂志文章abstract:OBJECTIVE:Despite an increased risk for suicide among individuals diagnosed with psychotic disorders, risk factors for completed suicide remain largely unexamined in this population. Using a case-control design, this study aimed to investigate clinical and behavioural risk factors for suicide completion in schizophreni...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2006.02.025
更新日期:2006-05-01 00:00:00
abstract::Auditory-verbal hallucinations (AVHs) are associated with an impaired connectivity of large-scale networks. To examine the relationship between white-matter integrity and AVHs, we conducted a meta-analysis of diffusion-tensor-imaging studies that compared patients with schizophrenia and AVHs with matched healthy contr...
journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析
doi:10.1016/j.schres.2014.07.014
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:Research participants must have adequate consent-related abilities to provide informed consent at the time of study enrollment. We sought to determine if research participants with schizophrenia maintain adequate consent-related abilities during a longitudinal study. If participants lose abilities during a tr...
journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.schres.2011.04.012
更新日期:2011-08-01 00:00:00
abstract::T1 and T2 relaxation times were measured in ten brain regions on the right and left side in a sample of 27 schizophrenic patients and 37 normal controls. The schizophrenic patients showed a prolongation of T2 relaxation time, and to a lesser extent of T1 relaxation time, which was more predominantly localized in the r...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/0920-9964(91)90080-b
更新日期:1991-10-01 00:00:00
abstract::The relationship between social cognition (i.e., cognition for social stimuli) and ward behavior among individuals with chronic schizophrenia was investigated. Twenty-seven inpatients completed a battery of cognitive and social-cognitive tasks and were rated by staff on various indices of ward behavior. Overall, there...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/0920-9964(96)00010-2
更新日期:1996-07-05 00:00:00
abstract:BACKGROUND:We previously developed a novel method of identifying children aged 9-12 years who may be at elevated risk of developing schizophrenia and the spectrum disorders because they present a triad of putative antecedents of schizophrenia (ASz). The present study aimed to determine whether ASz children also present...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.05.034
更新日期:2010-08-01 00:00:00
abstract::Affect perception has frequently been shown to be impaired in patients suffering from schizophrenia or bipolar disorder (BD), but it remains unclear whether these impairments exist during symptomatic remission and whether the two disorders differ from each other in this regard. Most previous studies have investigated ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.07.019
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVE:Individuals with both physical and mental health problems may have elevated levels of emergency department (ED) service utilization either for index conditions or for associated comorbidities. This study examines the use of ED services by Medicaid beneficiaries with comorbid diabetes and schizophrenia, a dyad...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.12.002
更新日期:2014-02-01 00:00:00
abstract::The minor neurological and cognitive deficits consistently reported in psychoses may reflect the same underlying brain dysfunction. Still, even in healthy individuals minor neurological abnormalities are associated with worse cognitive function. Therefore, establishing which neurological and cognitive deficits are spe...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2012.09.016
更新日期:2012-12-01 00:00:00
abstract::We examined the fractionation of executive functioning performance in ninety patients with schizophrenia, who were tested for initiation, sustained attention, switching/flexibility, attention allocation and impulsivity/disinhibition. The participants were also given tests of general intelligence and memory. We analyse...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2005.08.011
更新日期:2006-01-31 00:00:00
abstract::Brain morphometry has been studied extensively in schizophrenic patients, and among the cortical differences identified two consistent findings are decreased cerebellar vermal volume and increased volume of the fourth ventricle; although contradictory findings are reported as well. Recent cognitive activation studies ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(98)00137-6
更新日期:1999-05-04 00:00:00
abstract::Adolescents meeting diagnostic criteria for schizotypal personality disorder (SPD) are presumed to be at risk for developing schizophrenia in adulthood, making them an important group for exploring the developmental trajectory of the disease. Deficits in executive functioning have been documented in schizophrenia pati...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(99)00119-x
更新日期:2000-04-07 00:00:00
abstract::The EPSILON project (European Psychistric Services: Inputs Linked to Outcomes and Needs) is a cross-sectional study of the clinical and social characteristics, needs, satisfaction with services, quality of life, and service utilisation and costs for people with schizophrenia in five European sites (Amsterdam, Copenhag...
journal_title:Schizophrenia research
pub_type: 杂志文章,多中心研究
doi:10.1016/s0920-9964(01)00318-8
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:Neurodevelopmental models of schizophrenia suggest that cognitive deficits may be observed during childhood and adolescence, long before the onset of psychotic symptoms. Elucidating the trajectory of normal cognitive development during childhood and adolescence may therefore provide a basis for identifying s...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.11.023
更新日期:2014-01-01 00:00:00
abstract::Outcomes for people with schizophrenia-spectrum disorders (SSDs) are generally poor, making it important to understand risk states and illness transition. The network approach, which conceptualizes psychopathology as a network of causally interacting symptoms, may hold promise in this regard. Here, we present a networ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2019.01.046
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVES:Frontal hypoactivation has been consistently found in schizophrenia. We hypothesized that patients' deficit is asymmetrical, i.e., centred over the left frontal locations, associated with loss of language-related asymmetry, and correlated with positive symptoms. METHOD:The amplitude of EEG gamma band (36-48...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.04.003
更新日期:2015-06-01 00:00:00
abstract::Planning and executing goal-directed behaviours are critical final steps in translating motivation into action. Amotivation is a key feature of schizophrenia, but its impact on goal-directed functioning has not been extensively studied in an objective and ecologically valid manner. To address this, we investigated goa...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2018.10.012
更新日期:2019-04-01 00:00:00
abstract::By employing a novel semi-parametric extrapolation method, the life expectancies after the first hospitalization for schizophrenia and the associated lifetime healthcare expenditures were both estimated. Based on the linkage between the National Health Insurance Research Database and the National Mortality Registry of...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2016.01.033
更新日期:2016-03-01 00:00:00
abstract::Abnormality of P300 waveforms of event-related potentials (ERPs) has been suggested to represent an aspect of the pathophysiology of schizophrenia. Previous work points to the contribution of altered neural function in discrete brain regions in the left hemisphere to psychotic symptoms and cognitive deficits of schizo...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2008.01.020
更新日期:2008-04-01 00:00:00
abstract::This paper examines trait arousability (TA), a temperament characteristic, in 47 stable outpatients with schizophrenia and 50 non-psychiatric controls. Self-reported levels of stress were obtained during a negative and positive memory speech task. Levels of TA, and the association of TA scores with reported stress dur...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2004.01.008
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND:Autism spectrum disorder (ASD) and schizophrenia are neurodevelopmental conditions that are characterized by significant social impairment. Emerging genomic and neurobiological evidence has increasingly pointed to shared pathophysiologic mechanisms in the two disorders. Overlap in social impairment may refle...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2017.03.009
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:Tumor necrosis factor alpha (TNFalpha), a cytokine involved in inflammatory processes, has been implicated in the pathophysiology of schizophrenia. The chromosomal location in the major histocompatibility complex (MHC) region on 6p21.1-21.3, a region with evidence for linkage, suggests a role in susceptibili...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(02)00534-0
更新日期:2003-12-01 00:00:00
abstract::Recent studies of cerebral pathology in patients with schizophrenia have focused on symptomatological and electrophysiological correlates of reduced temporal lobe structure volumes. Volume deficits of the left superior temporal gyrus have been correlated with auditory hallucinations as well as to left-sided P300 ampli...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(99)00006-7
更新日期:1999-08-17 00:00:00
abstract:BACKGROUND:There remains a lack of agreement regarding criteria for treatment-resistant schizophrenia (TRS) and definition of response. METHOD:A literature search was conducted to identify clinical studies of antipsychotics in TRS using PubMed, EMBASE and PsycINFO (last search 31 July 2011). Psychopharmacological stud...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2011.09.016
更新日期:2011-12-01 00:00:00
abstract::Sleep disturbances have been reliably reported in patients with schizophrenia, thus suggesting that abnormal sleep may represent a core feature of this disorder. Traditional electroencephalographic studies investigating sleep architecture have found reduced deep non-rapid eye movement (NREM) sleep, or slow wave sleep ...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2016.05.023
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:The extent of heterogeneity in the long-term course of schizophrenia is unclear. AIMS:To examine the course of schizophrenia in a population-based cohort. METHODS:This study included all Israeli individuals born in 1970-1988, of North African or European origin (N=2290), entered in the National Psychiatric...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.10.026
更新日期:2011-03-01 00:00:00
abstract::The occurrence of a microdeletion at 22q11 has long been considered to constitute a risk factor for schizophrenia. Higher rates of 22q11 deletions have been reported in cohorts of patients with schizophrenia. In order to estimate the prevalence of the 22q11 deletion in schizophrenia patients more accurately, a screeni...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2004.02.008
更新日期:2005-03-01 00:00:00
abstract::The prevalence of obesity in schizophrenia patients is high, especially in chronic and medicated patients. Few studies have explored the relationships between obesity, cognition and clinical correlates in patients with schizophrenia. This study was designed to assess the prevalence and clinical correlates of obesity a...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2019.10.017
更新日期:2020-01-01 00:00:00
abstract::Schizophrenia is a complex disorder that is diagnosed mainly with clinical observation and evaluation. Recent studies suggest that many people with schizophrenia have abnormalities in the function of the N-methyl-d-aspartate receptor (NMDAR). The retina is part of the central nervous system and expresses the NMDAR, ra...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2019.09.005
更新日期:2020-05-01 00:00:00
abstract::Recent meta-analytic evidence suggests that clinical neuropsychological methods are not likely to uncover circumscribed cognitive impairments in the deficit syndrome of schizophrenia. To overcome this issue, we adapted a cognitive neuroscience perspective and used a new "chaining" habit learning task. Participants wer...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2007.06.027
更新日期:2008-02-01 00:00:00