Abstract：
BACKGROUND:Autism spectrum disorder (ASD) and schizophrenia are neurodevelopmental conditions that are characterized by significant social impairment. Emerging genomic and neurobiological evidence has increasingly pointed to shared pathophysiologic mechanisms in the two disorders. Overlap in social impairment may reflect similar underlying neural dysfunction in social-cognitive brain networks, yet few studies have directly compared brain function and communication between those with ASD and schizophrenia. METHODS:Outpatients with schizophrenia (n=36), ASD (n=33), and healthy volunteers (n=37) completed a visual perspective-taking task during functional neuroimaging at 3T to assess similarities and differences in fronto-temporal brain function and connectivity during social-cognitive processing. Analyses employed general linear models to examine differences in amplitude of BOLD-signal response between disorder groups, and computed functional connectivity coefficients to investigate differences in the connectivity profiles of networks implicated in social cognition. RESULTS:Despite similar behavioral impairments, participants with ASD and schizophrenia evidenced distinct neural abnormalities during perspective-taking. Functional activation results indicated reduced temporo-parietal junction and medial prefrontal activity in ASD compared to schizophrenia (all Puncor<0.002). Functional connectivity analyses further revealed significantly greater local orbitofrontal connectivity in ASD than schizophrenia (all PFDR<0.028) during perspective-taking. Differences in brain activation and connectivity were unrelated to antipsychotic medication dose. CONCLUSIONS:Autism and schizophrenia are characterized by similar social-cognitive impairments that may stem from different underlying abnormalities in the functional organization and communication of the social brain.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Eack SM,Wojtalik JA,Keshavan MS,Minshew NJdoi
10.1016/j.schres.2017.03.009subject
Has Abstractpub_date
2017-05-01 00:00:00pages
102-109eissn
0920-9964issn
1573-2509pii
S0920-9964(17)30130-5journal_volume
183pub_type
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journal_title：Schizophrenia research
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doi：10.1016/j.schres.2004.05.007
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pub_type： 杂志文章,随机对照试验
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pub_type： 杂志文章,多中心研究
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