Abstract:
BACKGROUND:The number of antipsychotic prescriptions dispensed annually in England has increased substantially over the past decade. It is not known whether this is due to changes in prescribing practices, or an increase in the prevalence of psychosis. To our knowledge, no previous studies have investigated temporal trends in prevalence of psychotic symptoms in non-clinical populations. METHODS:We used data from the nationally representative Adult Psychiatric Morbidity Surveys 2000, 2007 and 2014 to (1) test whether the prevalence of psychotic symptoms increased between 2000 and 2014; (2) compare prevalence of psychotic symptoms to the prevalence of being prescribed antipsychotic medication; and (3) identify correlates of experiencing psychotic symptoms. RESULTS:There was a small increase in the prevalence of psychotic symptoms in 2014 compared to 2000 (prevalence in 2000 5.6%, 95% confidence intervals (CI) 5.1% to 6.2%; prevalence in 2014 6.8%, 95% CI 6.1% - 7.6%). This corresponded to an adjusted odds ratio of 1.2 (95% CI 1.02-1.40, p=0.026) for experiencing psychotic symptoms in 2014 compared to 2007. By comparison, antipsychotic medication use doubled over this period (prevalence in 2000 0.6%, 95% CI 0.4%-0.7%; prevalence in 2014 1.2% 95% CI 0.9%-1.5%; aOR 2.22 (1.52-3.25) p<0.001). Correlates of reporting psychotic symptoms included ethnic minority identity, younger age, lower social class, alcohol and cannabis use, and any psychiatric diagnosis. CONCLUSIONS:While the rates of antipsychotic prescription doubled between 2000 and 2014, the odds of having psychotic symptoms rose only slightly. The reasons for this warrant further investigation.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Shoham N,Cooper C,Lewis G,Bebbington P,McManus Sdoi
10.1016/j.schres.2020.11.057subject
Has Abstractpub_date
2021-01-09 00:00:00pages
97-102eissn
0920-9964issn
1573-2509pii
S0920-9964(20)30645-9journal_volume
228pub_type
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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