Abstract：
INTRODUCTION:People with severe mental illness have greater risk of un-detected and inadequately treated medical disorders, adding up to the risk of premature death. This study investigated how chronic medical comorbidity evolved across the lifespan in schizophrenia and the associated impact on mortality. METHOD:A register-based retrospective nested case-control study was conducted, identifying incident cases of cardiovascular disease (CVD), chronic obstructive pulmonary disease (COPD), cancer and diabetes, as well as mortality due to these diseases, across the lifespan in schizophrenia. SAMPLE:A schizophrenia cohort consisting of 4924 individuals aged 18-40 years registered with a diagnosis of schizophrenia (ICD-8: 295.0-3 + 295.9) during admission to a psychiatric hospital unit in 1970-79. Schizophrenia cases were age and gender matched with 22,597 controls in the general population. RESULTS:Rate ratio (RR) of CVD and cancer were similar to controls. The RR of COPD and diabetes were increased across the lifespan. The probability of having been diagnosed prior to dying from CVD, cancer, pulmonary diseases or diabetes was markedly reduced in schizophrenia cases compared to controls. The RR of all-cause mortality and mortality from CVD, COPD and diabetes remained elevated in all age groups in schizophrenia. Registration of medical comorbidity was associated with increased survival. CONCLUSION:Excess medical comorbidity persists across the lifespan and into older age. No age-related decrease in incidence of major chronic medical comorbidities in schizophrenia was found except for diabetes.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Brink M,Green A,Bojesen AB,Lamberti JS,Conwell Y,Andersen Kdoi
10.1016/j.schres.2018.10.020subject
Has Abstractpub_date
2019-04-01 00:00:00pages
347-354eissn
0920-9964issn
1573-2509pii
S0920-9964(18)30622-4journal_volume
206pub_type
杂志文章abstract：:Glutamate was quantified by proton magnetic resonance spectroscopy ((1)H-MRS) in the medial frontal lobes of 15 adult siblings of individuals with schizophrenia (HR) and 14 healthy volunteers (HV), all of whom also completed a Continuous Performance Test (CPT). Subjects were free of psychopathology but the HR group sh...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.11.028
更新日期：2008-02-01 00:00:00
abstract：BACKGROUND:The aim of this study is to determine the rate of persistent negative symptoms according to different criteria during two years of follow-up after first-episode schizophrenia. METHODS:The study sample consisted of 105 patients with first-episode schizophrenia who completed at least 12 months of follow-up pe...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.07.021
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND:Aberrations in body perception are common in psychotic disorders. The insula and temporoparietal junction (TPJ) are involved in body ownership and spatial perception suggesting that abnormal structure of these regions might be related to the expression of perceptual aberrations in psychosis. METHODS:58 indi...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.10.005
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVE:Quality of life (QOL) is considered an important outcome in the treatment of schizophrenia, but the determinants of QOL are poorly understood in this population. Furthermore, previous studies have relied on combined measures of subjective QOL (usually defined as life satisfaction) and objective QOL (usually d...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.09.001
更新日期：2008-01-01 00:00:00
abstract：:Genetic epidemiological studies have demonstrated markedly reduced rates in reproduction among schizophrenic patients. According to evolutionary theory, behavioral and psychological phenotypes are selected based on ecological "fit". Where differential survival or reproductive success exists, genotype frequencies are a...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(00)00062-1
更新日期：2001-03-01 00:00:00
abstract：:Although pharmacologic treatments are available for patients with schizophrenia, little is known about how prescription patterns of atypical antipsychotic agents are related to patient characteristics. In this study, we examined the association between patient characteristics and the likelihood of being initiated on o...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2005.04.005
更新日期：2005-09-15 00:00:00
abstract：OBJECTIVE:The use of dopaminergic antagonist antipsychotics is associated with hyperprolactinemia, but some studies have found increased prolactin concentrations in antipsychotic-naive patients with schizophrenia and related disorders. We conducted a systematic review and meta-analysis of studies of prolactin in antips...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.schres.2016.03.018
更新日期：2016-07-01 00:00:00
abstract：:In schizophrenia, clinical, familial and biological characteristics according to age at onset (AAO) suggest that AAO is a valid candidate symptom for genetic studies. However, none of the various thresholds used to define AAO subgroups in schizophrenia has been validated. We aim to define different AAO subtypes by adm...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2004.02.002
更新日期：2004-11-01 00:00:00
abstract：BACKGROUND:We previously developed a novel method of identifying children aged 9-12 years who may be at elevated risk of developing schizophrenia and the spectrum disorders because they present a triad of putative antecedents of schizophrenia (ASz). The present study aimed to determine whether ASz children also present...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2010.05.034
更新日期：2010-08-01 00:00:00
abstract：BACKGROUND:Psychotic-like experiences (PLEs) during adolescence are not uncommon and potentially represent a clinical and public health concern. A greater understanding of their aetiology and patterns of change over time is needed. We aimed to describe trajectories of PLEs during adolescence, and examine their associat...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.06.024
更新日期：2012-09-01 00:00:00
abstract：INTRODUCTION:Contextual factors representing chronic stressors, such as neighborhood crime characteristics, have been repeatedly linked to compromised mental and physical health, and may contribute to the pathologizing of normative/non-clinical experiences. However, the impact of such structural factors has seldom been...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.11.024
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVE:Self-rated attenuated psychotic-like experiences (APLEs) are increasingly used to screen for ultra-high-risk (UHR) across all ages. However, self-rated psychotic-like experiences (PLEs), in particular perception-related ones, were more frequent in children and adolescents, in which they possessed less clinica...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.schres.2014.10.005
更新日期：2014-12-01 00:00:00
abstract：:We tested the hypothesis that the expression of schizophrenic psychopathology is dependent on the stage of adolescent development. The study had a retrospective design, using high-quality case-note material of cases of schizophrenia at first admission. Patients with onset of illness between the age of 11 and 21 years ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(94)00020-9
更新日期：1995-01-01 00:00:00
abstract：:Cholesterol metabolism is vital for brain function. Previous work in cultured cells has shown that a number of psychotropic drugs inhibit the activity of 7-dehydrocholesterol reductase (DHCR7), an enzyme that catalyzes the final steps in cholesterol biosynthesis. This leads to the accumulation of 7-dehydrocholesterol ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.02.001
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:Prenatal micronutrient deficiency has been linked to later development of schizophrenia among offspring; however, no study has specifically investigated the association between vitamin A and this disorder. Vitamin A is an essential nutrient which is required by the early embryo and fetus for gene expression ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.02.004
更新日期：2012-05-01 00:00:00
abstract：:Research has demonstrated that individuals with schizophrenia fail to appropriately use negative feedback to guide learning. These learning deficits are thought to arise from abnormalities in midbrain dopamine activity. Primary and enduring negative symptoms are also associated with abnormal dopamine activity and are ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.07.052
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:Altered motor behavior has consistently been reported in medication-naive adult patients with schizophrenia and first episode psychosis and adults at clinical high risk for psychosis (CHR). This study is the first to evaluate the prevalence of abnormal involuntary movements in a community sample of children ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.04.032
更新日期：2016-07-01 00:00:00
abstract：:We sought to identify the functional correlates of reduced magnetic resonance imaging (MRI) volumes of the superior temporal gyrus (STG) and the fusiform gyrus (FG) in patients with chronic schizophrenia. MRI volumes, positive/negative symptoms, and neuropsychological tests of facial memory and executive functioning w...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2006.11.025
更新日期：2007-03-01 00:00:00
abstract：:Minor physical anomalies (MPAs) are more prevalent amongst individuals with psychosis, supporting a neurodevelopmental model for psychotic disorders. The aim of this study was to investigate the possibility that neurodevelopmental adversity contributes to the excess of psychosis found in some ethnic groups in the UK. ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2006.08.019
更新日期：2007-01-01 00:00:00
abstract：:Impaired insight is a hallmark feature of schizophrenia. Structural studies implicate predominantly prefrontal, cingulate, cuneus/precuneus, and inferior temporal brain regions. The cortical midline structures (CMS) are also implicated in functional studies primarily through self-reflective processing tasks. However, ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.11.005
更新日期：2017-05-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(93)90074-s
更新日期：1993-06-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.02.011
更新日期：2014-04-01 00:00:00
abstract：BACKGROUND:Severity of negative symptoms has been associated with poor functioning, cognitive deficits, and defeatist beliefs in schizophrenia patients. However, one area that remains understudied is persistent negative symptoms (PNS). Negative symptoms, including PNS, have been observed in those at clinical high-risk ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2020.04.004
更新日期：2020-04-30 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/S0920-9964(96)00082-5
更新日期：1997-01-17 00:00:00
abstract：BACKGROUND:Neurological soft signs (NSS) are intrinsic features of psychosis that appear years before beginning a drug treatment. However, whether NSS respond to antipsychotics and whether these changes are clinically reliable and significant remains to be seen. OBJECTIVE:We sought to determine the effect of antipsych...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.05.019
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND:A small but significant association between schizophrenia and violence is open to a number of explanations. Impaired empathy has been associated with schizophrenia, and with violence in the general population. Our aim was to conduct a systematic review of any research into relationships between schizophrenia...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2012.07.019
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND:Suicide is one of the leading causes of death in young individuals. Timely and adequate identification of individuals with suicidal ideation could prevent from suicidal behavior. Psychotic experiences (PE) have been shown to increase levels of suicidal ideation (SI) in the general population. Therefore, deta...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.05.020
更新日期：2018-11-01 00:00:00
abstract：OBJECTIVES:Frontal hypoactivation has been consistently found in schizophrenia. We hypothesized that patients' deficit is asymmetrical, i.e., centred over the left frontal locations, associated with loss of language-related asymmetry, and correlated with positive symptoms. METHOD:The amplitude of EEG gamma band (36-48...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.04.003
更新日期：2015-06-01 00:00:00
abstract：:Affective impairments were examined in patients with and without deficit syndrome schizophrenia. Two Emotional Stroop tasks designed to measure automatic processing of emotional information were administered to deficit (n=15) and non-deficit syndrome (n=26) schizophrenia patients classified according to the Schedule f...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2008.01.014
更新日期：2008-07-01 00:00:00
abstract：:A disturbance of "minimal self," - of the immediate sense of mine-ness inherent in experience-is hypothesized to be the core disturbance in schizophrenia. Research with the Examination of Anomalous Self Experience (EASE) has demonstrated the selective aggregation of anomalous self-experiences in the schizophrenia spec...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.07.001
更新日期：2019-09-01 00:00:00
