Abstract：
:Minor physical anomalies (MPAs) are more prevalent amongst individuals with psychosis, supporting a neurodevelopmental model for psychotic disorders. The aim of this study was to investigate the possibility that neurodevelopmental adversity contributes to the excess of psychosis found in some ethnic groups in the UK. Subjects with first onset psychosis and healthy neighbourhood controls were enrolled in the AESOP study in South East London and Nottingham between 1997 and 1999. MPA rates were estimated in four broad ethnic groupings (White, African Caribbean, Black African and Other). Patients (n=245) had a higher mean total MPA score than healthy controls (n=158). This held true across each of the four ethnic groupings. The results of this study suggest that neurodevelopmental factors play a role in the aetiology of psychosis across all ethnic groups.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Dean K,Dazzan P,Lloyd T,Morgan C,Morgan K,Doody GA,Hutchinson G,Orr K,Jones PB,Murray RM,Fearon Pdoi
10.1016/j.schres.2006.08.019subject
Has Abstractpub_date
2007-01-01 00:00:00pages
86-90issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(06)00383-5journal_volume
89pub_type
杂志文章abstract：:Accumulating evidence showed that interleukin-2 (IL-2) may be involved in the pathophysiology of schizophrenia. Increased IL-2 levels have been found in the serum of schizophrenia patients with mixed results. In the present study, we assessed serum IL-2 levels in a large group of 160 schizophrenia patients compared to...
journal_title：Schizophrenia research
pub_type： 杂志文章
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更新日期：2015-12-01 00:00:00
abstract：:This study tested the hypothesis that maternal exposure to terror attacks during pregnancy is associated with the risk of schizophrenia in the offspring. A population-based study was conducted of Israeli children born between 1975 and 1995 and that were registered in the Ministry of Interior and followed up in the Min...
journal_title：Schizophrenia research
pub_type： 杂志文章
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更新日期：2018-09-01 00:00:00
abstract：:Recent transcriptomic, proteomic and metabolomics studies have highlighted an abnormal cerebral glucose and energy metabolism as one of the potential pathophysiological mechanisms of schizophrenia. This raises the possibility that a metabolically-based intervention might have therapeutic value in the management of sch...
journal_title：Schizophrenia research
pub_type： 杂志文章
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更新日期：2019-04-01 00:00:00
abstract：:Previous diffusion tensor imaging (DTI) studies have shown structural abnormalities of the cingulum bundle (CB) in patients with schizophrenia. However, regional specificity and functional relevance of the pregenual and dorsal CB subdivisions has not been fully studied. In the current study, 31 patients with schizophr...
journal_title：Schizophrenia research
pub_type： 杂志文章
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更新日期：2009-10-01 00:00:00
abstract：:Although the concept of remission has been widely accepted and utilized in depression and anxiety disorders, there has been much less emphasis on defining remission in schizophrenia. Recently, an expert consensus definition of remission in schizophrenia was proposed along specific operational criteria for the attainme...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.05.003
更新日期：2007-11-01 00:00:00
abstract：:Schizophrenia is associated with impairments in social interactions, and the conditions under which patients live and undergo treatment appear to have an important role in the course of the disease. However, the influences of care settings on the course of cognition remain controversial. The closure of psychiatric hos...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.03.015
更新日期：2014-05-01 00:00:00
abstract：:The degree of cortical atrophy as revealed by computed tomographic scans was assessed in 124 patients meeting the DSM III criteria for schizophrenia and in 45 age- and sex-matched healthy controls. 21 patients, i.e., 33% of the entire sample, showed moderate to severe atrophy. The presence of atrophy was not associate...
journal_title：Schizophrenia research
pub_type： 杂志文章
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更新日期：1988-09-01 00:00:00
abstract：:Brain morphometry has been studied extensively in schizophrenic patients, and among the cortical differences identified two consistent findings are decreased cerebellar vermal volume and increased volume of the fourth ventricle; although contradictory findings are reported as well. Recent cognitive activation studies ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(98)00137-6
更新日期：1999-05-04 00:00:00
abstract：:Patients with schizophrenia exhibit impairments in prepulse inhibition (PPI) of the startle response. Available data suggest that atypical antipsychotics may be more effective than typical antipsychotics in improving PPI deficits in schizophrenia. However, previous studies have used between-subjects rather than longit...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.09.035
更新日期：2009-12-01 00:00:00
abstract：:Second-generation antipsychotics have demonstrated efficacy for patients with schizophrenia but are associated with wide-ranging side effects. Brexpiprazole, a serotonin-dopamine activity modulator, has demonstrated efficacy in adult patients with schizophrenia. This paper provides an overview of the safety and tolera...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.schres.2016.04.013
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:Severity of negative symptoms has been associated with poor functioning, cognitive deficits, and defeatist beliefs in schizophrenia patients. However, one area that remains understudied is persistent negative symptoms (PNS). Negative symptoms, including PNS, have been observed in those at clinical high-risk ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2020.04.004
更新日期：2020-04-30 00:00:00
abstract：BACKGROUND:Recovery is the ultimate goal of psychosis treatment. Basic self-disturbances (BSDs) are non-psychotic phenomena associated with clinical outcome, present in prodromal, psychotic and residual phases of psychotic disorders. AIM:To investigate the relationship between BSDs and recovery seven years after first...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.08.009
更新日期：2019-10-01 00:00:00
abstract：OBJECTIVE:To assess the prevalence and correlates of antipsychotic polypharmacy (APP) across decades and regions. METHODS:Electronic PubMed/Google Scholar search for studies reporting on APP, published from 1970 to 05/2009. Median rates and interquartile ranges (IQR) were calculated and compared using non-parametric t...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.schres.2012.03.018
更新日期：2012-06-01 00:00:00
abstract：BACKGROUND:Aberrations in body perception are common in psychotic disorders. The insula and temporoparietal junction (TPJ) are involved in body ownership and spatial perception suggesting that abnormal structure of these regions might be related to the expression of perceptual aberrations in psychosis. METHODS:58 indi...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.10.005
更新日期：2017-01-01 00:00:00
abstract：:Patients with schizophrenia demonstrate a variety of attentional impairments which have proven difficult to relate to specific neural systems. Posner et al. (1988) reported an asymmetric slowing of right visual field orienting in schizophrenia similar to that observed in patients with parietal lesions. We examined the...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(92)90013-u
更新日期：1992-09-01 00:00:00
abstract：BACKGROUND:Despite the effectiveness of anti-psychotic pharmacotherapy, residual hallucinations and delusions do not completely resolve in some medicated patients. Additional cognitive behavioral therapy (CBT) seems to improve the management of positive symptoms. Despite promising results, the efficacy of CBT is still ...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析
doi：10.1016/j.schres.2005.02.018
更新日期：2005-09-01 00:00:00
abstract：:Grey matter brain networks are disrupted in schizophrenia, but it is still unclear at which point during the development of the illness these disruptions arise and whether these can be associated with behavioural predictors of schizophrenia. We investigated if single-subject grey matter networks were disrupted in a sa...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.08.025
更新日期：2015-10-01 00:00:00
abstract：BACKGROUND:Pharmaceutical companies conduct clinical trials to show the efficacy and safety of new medications for the treatment of schizophrenia. After the new medications are marketed, clinicians treating patients with schizophrenia discover that a considerable number of patients do not respond to these new medicatio...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2017.03.020
更新日期：2017-12-01 00:00:00
abstract：:In view of prior reports suggesting associations between polymorphisms of the tumor necrosis factor gene (TNF) and schizophrenia, we sequenced all exons, introns and 7 kb flanking sequence at TNF in DNA pooled from 125 Caucasian schizophrenia cases and 200 controls. We identified 18 SNPs of which we selected and genot...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2005.12.853
更新日期：2006-03-01 00:00:00
abstract：OBJECTIVE:To explore the impact of the introduction of newer antipsychotic long-acting injections (LAIs) on trends in LAI prescribing and characteristics associated with initiation of LAIs in naturalistic conditions. METHODS:The study was performed using reimbursement data from the French Insurance Healthcare system. ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.09.014
更新日期：2016-12-01 00:00:00
abstract：:Cortical thickness may be useful as a treatment response predictor in first-episode (FE) patients with schizophrenia, although this possibility has been scarcely assessed. In this study we assessed the possible relation between cortical thickness in regions of interest selected because of previously reported structura...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.06.042
更新日期：2014-09-01 00:00:00
abstract：:Psychotic-like experiences (PLEs) are part of a continuum of psychosis. Previous longitudinal studies highlighted a relationship between peripheral inflammation during childhood and onset of PLEs in adulthood. In this study, we tested if this association is mediated by internalising and externalising symptoms experien...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2020.11.009
更新日期：2020-12-01 00:00:00
abstract：:Fragile X mental retardation protein (FMRP) is an RNA binding protein with 842 target mRNAs in mammalian brain. Silencing of the fragile X mental retardation 1 (FMR1) gene leads to loss of expression of FMRP and upregulated metabotropic glutamate receptor 5 (mGluR5) signaling resulting in the multiple physical and cog...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.04.012
更新日期：2015-07-01 00:00:00
abstract：:This prospective study examined the effect of medication compliance and substance abuse on 4 year outcome in 99 patients following a relapse of schizophrenia. Univariate survival analysis revealed longer community tenure in patients if they were over the age of 35 years, not admitted 2 years prior to the index episode...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(01)00261-4
更新日期：2002-04-01 00:00:00
abstract：OBJECTIVE:Corpus callosum (CC) size and interhemispheric communication differences have been reported between patients with schizophrenia and normal controls. Childhood-onset schizophrenia (COS) is a severe form of the disorder that is continuous with later-onset disorder. Corpus callosal area was examined for COS at i...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(02)00354-7
更新日期：2003-07-01 00:00:00
abstract：BACKGROUND:The aim of this study is to determine the rate of persistent negative symptoms according to different criteria during two years of follow-up after first-episode schizophrenia. METHODS:The study sample consisted of 105 patients with first-episode schizophrenia who completed at least 12 months of follow-up pe...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.07.021
更新日期：2014-09-01 00:00:00
abstract：:The SELENBP1 gene previously was found to be up-regulated in microarray analysis of both peripheral blood cell and brain tissue samples from schizophrenia patients. Quantitative PCR analysis subsequently corroborated the altered expression of SELENBP1 in schizophrenia brain tissue samples from the Stanley Array Correc...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.06.011
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:There is evidence that schizophrenia is a neuro-immune disorder. Genes linked to intragenic LINE-1 methylation show a strong association with immune-associated disorders including psychosis. The aim of this study was to examine LINE-1 methylation patterns in paranoid schizophrenia and methamphetamine-induced...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.02.015
更新日期：2019-06-01 00:00:00
abstract：:Nondeclarative memory (NDM) has subtypes associated with different brain regions; learning of a probabilistic classification task is impaired by striatal damage and learning of a gambling task is impaired by ventromedial prefrontocortical damage. Typical and atypical antipsychotic medications differentially affect imm...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(02)00315-8
更新日期：2003-06-01 00:00:00
abstract：:We examined the fractionation of executive functioning performance in ninety patients with schizophrenia, who were tested for initiation, sustained attention, switching/flexibility, attention allocation and impulsivity/disinhibition. The participants were also given tests of general intelligence and memory. We analyse...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2005.08.011
更新日期：2006-01-31 00:00:00
