Abstract:
:Schizophrenia is associated with impairments in social interactions, and the conditions under which patients live and undergo treatment appear to have an important role in the course of the disease. However, the influences of care settings on the course of cognition remain controversial. The closure of psychiatric hospitals and the transition to community-based living is a golden opportunity to address this issue. The aims of the present study were to examine (1) the longitudinal course of cognition as well as the psychopathology and social functioning of schizophrenia patients who had been chronically hospitalized and then discharged, and (2) the key cognitive predictors of the functional outcome of such patients. Seventy-eight patients were transferred to the community after the closure of a psychiatric hospital. These patients were followed-up for 5 years and underwent annual examinations that included measures of cognition, psychiatric symptoms, and social functioning. Fifty-six patients completed all the assessments. Although consistent improvements were shown in the cognitive domains for attention and memory, the initial improvements in global cognition and processing speed ultimately began to decline. Symptoms and global functioning improved almost consistently over the course of the follow-up period. Stepwise multiple regressions revealed category fluency at baseline predicted social functioning at 5 years. However, this correlation was no longer significant when psychopathological variables were included as predictors. These results suggest that care settings affect the course of cognition, and addressing these conditions may lead to a certain degree of cognitive improvement even among schizophrenia patients who have been chronically institutionalized.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Nemoto T,Niimura H,Ryu Y,Sakuma K,Mizuno Mdoi
10.1016/j.schres.2014.03.015subject
Has Abstractpub_date
2014-05-01 00:00:00pages
90-5issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(14)00123-6journal_volume
155pub_type
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pub_type: 杂志文章,随机对照试验
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更新日期:2005-06-15 00:00:00
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pub_type: 杂志文章
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更新日期:2008-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-10-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2019-01-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-12-01 00:00:00
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2009-11-01 00:00:00
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更新日期:2020-01-31 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2018-10-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,多中心研究
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更新日期:2002-08-01 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2015-03-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.schres.2016.03.018
更新日期:2016-07-01 00:00:00