Abstract:
:In this study we use high resolution Magnetic Resonance imaging (MRI) and apply rigorous manual tracing criteria in order to assess volumetrically the prefrontal cortex (PFC) in schizophrenia. Previous MRI studies suggested PFC is included in neural systems necessary for emotional processing and cognition, and regional PFC abnormalities might, thus, lead to specific negative symptoms, as well as a frequent association of poorer performance in category switching. The aim of this study was to use 3T imaging and reliable manual parcellation to determine if, as hypothesized, this higher precision would reveal additional MRI abnormalities in PFC in schizophrenia, and an association between PFC abnormalities and specific negative symptoms, as well as in category switching. Using 3-T MRI, 27 schizophrenia patients and 27 healthy controls were examined. PFC was manually parcellated into frontal pole, superior frontal gyrus (SFG), middle frontal gyrus (MFG), and inferior frontal gyrus (IFG). Left SFG (p=0.004), bilateral MFG (left: p=0.007; right: p=0.007), and bilateral IFG (left: p<0.001; right: p=0.002) showed volume reduction. There were symptom associations between smaller left MFG volumes and more affective flattening (R=-0.465, p=0.015), and smaller left IFG volumes and poorer performance on the alternating semantic category test (R=0.440, p=0.025). In summary, 3-T imaging revealed widespread gyral volume deficits in PFC gyri, and specific associations with selective negative symptoms, such as affective flattening, and with deficits in cognitive switching.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Ohtani T,Levitt JJ,Nestor PG,Kawashima T,Asami T,Shenton ME,Niznikiewicz M,McCarley RWdoi
10.1016/j.schres.2013.10.026subject
Has Abstractpub_date
2014-01-01 00:00:00pages
184-90issue
1eissn
0920-9964issn
1573-2509pii
S0920-9964(13)00576-8journal_volume
152pub_type
杂志文章abstract:OBJECTIVE:Clozapine is associated with significant weight gain. However, it is still debatable whether the majority of weight gain occurs in the early phase of treatment or if weight gain is a persistent side effect. The inconsistent results in previous outpatient studies may be due to many confounding factors, such as...
journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章
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abstract::Accumulating evidence showed that interleukin-2 (IL-2) may be involved in the pathophysiology of schizophrenia. Increased IL-2 levels have been found in the serum of schizophrenia patients with mixed results. In the present study, we assessed serum IL-2 levels in a large group of 160 schizophrenia patients compared to...
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.03.022
更新日期:2014-06-01 00:00:00
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journal_title:Schizophrenia research
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pub_type: 杂志文章
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更新日期:1995-01-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2018.03.006
更新日期:2018-09-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2015-05-01 00:00:00
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journal_title:Schizophrenia research
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doi:10.1016/j.schres.2018.09.007
更新日期:2019-02-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2008.11.028
更新日期:2009-04-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.11.004
更新日期:2015-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.06.009
更新日期:2015-08-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2020.06.032
更新日期:2020-09-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2008.03.012
更新日期:2008-07-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2005.09.004
更新日期:2006-01-31 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.11.005
更新日期:2010-02-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0920-9964(98)00026-7
更新日期:1998-05-25 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/0920-9964(95)00024-g
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doi:10.1016/j.schres.2018.10.009
更新日期:2019-04-01 00:00:00
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更新日期:2000-11-30 00:00:00
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pub_type: 杂志文章
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更新日期:2006-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-07-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2020.08.016
更新日期:2020-10-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/S0920-9964(03)00102-6
更新日期:2004-02-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2012.10.031
更新日期:2013-01-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2006.04.018
更新日期:2006-09-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.schres.2016.03.020
更新日期:2016-07-01 00:00:00