Abstract：
:Despite robust evidence of neurocognitive dysfunction in psychotic patients, the degree of similarity in cognitive architecture across psychotic disorders and among their respective first-degree relatives is not well delineated. The present study examined the latent factor structure of the Brief Assessment of Cognition in Schizophrenia (BACS) neuropsychological battery. Analyses were conducted on 783 psychosis spectrum probands (schizophrenia, schizoaffective, psychotic bipolar), 887 of their first-degree relatives, and 396 non-psychiatric controls from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) consortium. Exploratory factor analysis of BACS subtest scores indicated a single-factor solution that was similar across all groups and provided the best overall data fit in confirmatory analyses. Correlations between the standard BACS composite score and the sum of subscale scores weighted by their loadings on this unitary factor were very high in all groups (r≥.99). Thus, the BACS assesses a similar unitary cognitive construct in probands with different psychotic disorders, in their first-degree relatives, and in healthy controls, and this factor is well measured by the test's standard composite score.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Hochberger WC,Hill SK,Nelson CL,Reilly JL,Keefe RS,Pearlson GD,Keshavan MS,Tamminga CA,Clementz BA,Sweeney JAdoi
10.1016/j.schres.2015.11.022subject
Has Abstractpub_date
2016-01-01 00:00:00pages
156-61issue
1eissn
0920-9964issn
1573-2509pii
S0920-9964(15)30065-7journal_volume
170pub_type
杂志文章abstract：:Left or mixed-handedness, footedness, and eye dominance are thought to indicate abnormalities in lateralization related to schizophrenia. Increased left or mixed-dominance in schizophrenia suggests possible hemispheric abnormalities associated with the disorder. A related body of research suggests that some indication...
journal_title：Schizophrenia research
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Schizophrenia research
pub_type： 杂志文章
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.01.022
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journal_title：Schizophrenia research
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更新日期：2015-12-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2011.06.023
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/j.schres.2019.11.024
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pub_type： 杂志文章,评审
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更新日期：2014-02-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2012-03-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.03.024
更新日期：2009-06-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章,多中心研究
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journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析
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更新日期：2018-01-01 00:00:00
abstract：:Structural abnormalities in the lateral prefrontal cortex (LPFC) are well-documented in schizophrenia and recent evidence suggests that these abnormalities relate to functional outcome. Cognitive control mechanisms, reliant on the LPFC, are impaired in schizophrenia and predict functional outcome, thus impaired cognit...
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pub_type： 杂志文章
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