Abstract：
:Postmortem studies have suggested that there is abnormal GABAergic activity in the hippocampus in schizophrenia (SZ). In micro-dissected human hippocampal slices, a loss of interneurons and a compensatory upregulation of GABAA receptor binding activity on interneurons, but not PNs, has suggested that disinhibitory GABA-to-GABA connections are abnormal in stratum oriens (SO) of CA3/2, but not CA1, in schizophrenia. Abnormal expression changes in the expression of kainate receptor (KAR) subunits 5, 6 and 7, as well as an inwardly-rectifying hyperpolarization-activated cationic channel (Ih3; HCN3) may play important roles in regulating GABA cell activity at the SO CA3/2 locus. The exclusive neurons at this site are GABAergic interneurons; these cells also receive direct projections from the basolateral amygdala (BLA). When the BLA is stimulated by stereotaxic infusion of picrotoxin in rats, KARs influence axodendritic and presynaptic inhibitory mechanisms that regulate both inhibitory and disinhibitory interneurons in the SO-CA3/2 locus. The rat model described here was specifically developed to extend our understanding of these and other postmortem findings and has suggested that GABAergic abnormalities and possible disturbances in oscillatory rhythms may be related to a dysfunction of disinhibitory interneurons at the SO-CA3/2 site of schizophrenics.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Benes FMdoi
10.1016/j.schres.2015.01.014subject
Has Abstractpub_date
2015-09-01 00:00:00pages
73-83issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(15)00018-3journal_volume
167pub_type
杂志文章,评审abstract：OBJECTIVE:Clozapine is associated with significant weight gain. However, it is still debatable whether the majority of weight gain occurs in the early phase of treatment or if weight gain is a persistent side effect. The inconsistent results in previous outpatient studies may be due to many confounding factors, such as...
journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章
doi：10.1016/j.schres.2008.10.023
更新日期：2009-03-01 00:00:00
abstract：OBJECTIVES:Psychosis is associated with increased subjective and altered endocrine and autonomic nervous system stress-reactivity. Psychosis patients often experience auditory verbal hallucinations, with negative voice content being particularly associated with distress. The present study developed a voice-simulation p...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.07.019
更新日期：2019-08-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.01.029
更新日期：2016-03-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.08.013
更新日期：2019-10-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2014.11.016
更新日期：2015-02-01 00:00:00
abstract：:CACNA1C (12p13.3) has been implicated as a susceptibility gene for schizophrenia by several replicated genome wide association studies. While these results have been consistent among studies in European populations, the findings in East Asian populations have varied. To test whether CACNA1C is a risk gene for schizoph...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析
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更新日期：2014-01-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(01)00176-1
更新日期：2002-01-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2010.01.033
更新日期：2010-06-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2004.02.002
更新日期：2004-11-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.07.018
更新日期：2019-10-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2006.07.011
更新日期：2006-12-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章
doi：10.1016/j.schres.2003.12.003
更新日期：2004-10-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.08.012
更新日期：2016-10-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(02)00353-5
更新日期：2003-10-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.08.020
更新日期：2012-12-01 00:00:00
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pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2011.11.036
更新日期：2012-03-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(95)00087-9
更新日期：1996-05-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1016/j.schres.2017.03.020
更新日期：2017-12-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.schres.2012.02.017
更新日期：2012-05-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/S0920-9964(97)00090-X
更新日期：1997-10-17 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2004.12.011
更新日期：2005-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.schres.2010.09.003
更新日期：2011-03-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.05.017
更新日期：2015-08-01 00:00:00
abstract：BACKGROUND:The 22q11.2 deletion syndrome (22q11DS) is one of the highest known risk factors for schizophrenia and recent findings have highlighted the clinical relevance of ultra-high risk (UHR) criteria in this population. However, studies in other at-risk populations have shown that the presence of negative symptoms ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.10.014
更新日期：2019-04-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2003.08.007
更新日期：2004-04-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.05.031
更新日期：2019-08-01 00:00:00
abstract：OBJECTIVE:Corpus callosum (CC) size and interhemispheric communication differences have been reported between patients with schizophrenia and normal controls. Childhood-onset schizophrenia (COS) is a severe form of the disorder that is continuous with later-onset disorder. Corpus callosal area was examined for COS at i...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(02)00354-7
更新日期：2003-07-01 00:00:00
abstract：BACKGROUND:Cognitive Remediation (CR) is an evidence based treatment targeting cognitive and functional difficulties in people with psychosis. Despite the large number of effectiveness studies, only limited evidence exists for the active ingredients of this therapy. This study begins to fill this gap by exploring the r...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2017.09.012
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Gamma-aminobutyric acid (GABA) dysfunction and its consequent imbalance are implicated in the pathophysiology of schizophrenia. Reduced GABA production would lead to a disinhibition of glutamatergic neurons and subsequently cause a disruption of the modulation between GABAergic interneurons and glutamatergic...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.07.021
更新日期：2018-03-01 00:00:00
abstract：OBJECTIVE:The onset of psychosis is thought to be preceded by neurodevelopmental changes in the brain. However, the timing of these changes has not been established. We investigated structural brain changes in a sample of young adolescents (12-18 years) at ultra high-risk for psychosis (UHR). METHODS:Structural MRI da...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.04.013
更新日期：2009-07-01 00:00:00
