Abstract：
:In 1990 a satellite session of the American College of Neuropsychopharmacology (ACNP) Annual Meeting was held that focused on the question of whether progressive changes in brain structure occur in schizophrenia and this session raised considerable controversy. Eighteen years later, on December 12, 2008, after much data have since accumulated on this topic, a group of approximately 45 researchers gathered after the annual ACNP meeting to participate in a similar workshop on several unresolved questions still remaining: (1) How strong and consistent is the evidence? (2) Is there anatomic specificity to changes and is it disease specific or subject specific? (3) What is the time course? (4) What is the underlying pathophysiology (i.e. is it central to the disease process or is it due to neuroleptic treatment or other epiphenomena? (5) What is its clinical significance? and (6) Are there treatment implications? The day was chaired by Lynn E. DeLisi and co-chaired by Stephen J. Wood. Christos Pantelis and Jeffrey A. Lieberman extensively helped with its planning. The ACNP assisted in its organization as an official satellite of its annual meeting and several pharmaceutical companies provided support with unrestricted educational grants. The following is a summary of the sessions as recounted by rapporteurs whose job was to record as closely as possible the outcome of discussions on the above outlined questions.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Borgwardt SJ,Dickey C,Hulshoff Pol H,Whitford TJ,DeLisi LEdoi
10.1016/j.schres.2009.04.025subject
Has Abstractpub_date
2009-07-01 00:00:00pages
32-45issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(09)00212-6journal_volume
112pub_type
杂志文章abstract：:We previously reported a schizophrenia associated reduction of neuronal and oligodendrocyte number in the anterior principal thalamic nucleus (APN) in a cohort of severely impaired elderly subjects with schizophrenia (SZ) relative to age matched nonpsychiatric controls (NCs). The present study was undertaken to determ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2008.08.023
更新日期：2008-12-01 00:00:00
abstract：:Atypical antipsychotic drugs (AAPDs) are widely used in children and adolescents to treat a variety of psychiatric disorders. However, little is known about the long-term effects of AAPD treatment before the brain is fully developed. Indeed, we and others have previously reported that treatment of adolescent rats with...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.10.034
更新日期：2015-02-01 00:00:00
abstract：:High exposure to green space and natural environments has previously been associated with lower schizophrenia rates possibly through low air pollution and improved psychological restoration. Exposure to natural environments could explain the negative urban-rural gradient of schizophrenia, but it is unclear if all natu...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.10.012
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Metabolic abnormalities and weight gain are an important problem in patients with schizophrenia. An instrument to evaluate body image and self-esteem related to weight has recently been developed (B-WISE). The first objective was to evaluate whether the findings of the original validation study could be conf...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2006.07.025
更新日期：2006-12-01 00:00:00
abstract：BACKGROUND:A potential link between increase in total cholesterol and triglycerides and clinical improvement has been observed during antipsychotic drug treatment in chronic schizophrenia patients, possibly due to drug related effects on lipid biosynthesis. We examined whether changes in serum lipids are associated wit...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.10.042
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:While structural brain imaging abnormalities have been identified in schizophrenia and related disorders, it is unclear when they arise. Some appear to predate the illness and may be genetic in origin, while others are associated with the onset of the disorder. METHODS:We examined the hippocampal volumes an...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2004.10.008
更新日期：2005-06-15 00:00:00
abstract：OBJECTIVE:Quality of life (QOL) is considered an important outcome in the treatment of schizophrenia, but the determinants of QOL are poorly understood in this population. Furthermore, previous studies have relied on combined measures of subjective QOL (usually defined as life satisfaction) and objective QOL (usually d...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.09.001
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVE:We examined the relationship between cerebral gray matter (GM) volume and severity of delusions and hallucinations in adults with schizophrenia. METHOD:MRI scans in 43 patients with schizophrenia were acquired. Correlations were computed between GM volume and clinician ratings of hallucinations and delusions...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2011.08.004
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND:Symptomatic remission and its associated factors have been evaluated in several studies of younger schizophrenic patients. Although the number of older individuals with schizophrenia is rapidly growing, evaluations of remission in elderly patients are scarce and limited to samples of convenience, questioning...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2010.09.003
更新日期：2011-03-01 00:00:00
abstract：BACKGROUND:Family studies have suggested that schizophrenia and bipolar disorders share some susceptibility factors. Schizotypal personality disorder (SPD) may be an intermediate phenotype common both to schizophrenia and bipolar disorders. We explored the familiality of schizotypal dimensions by comparing the magnitud...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2005.07.009
更新日期：2005-12-15 00:00:00
abstract：:There is strong evidence that hippocampal 5-hydroxytryptamine (5-HT) systems are affected in schizophrenia and hence we have studied a number of markers of the 5-HT system in hippocampi from subjects with schizophrenia. Using in situ radioligand binding with autoradiography we measured [(3)H]proplyamino-8-hydroxy-1,2,...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2004.02.007
更新日期：2004-12-01 00:00:00
abstract：:The accuracy of the WAIS-R seven subtest short form (Ward, L.C., 1990. Prediction of Verbal, Performance and Full Scale IQs from seven subtests of the WAIS-R. J. Clin. Psychol. 46, 436-440) was examined for predicting IQs of 73 inpatients diagnosed with schizophrenia. Results indicated that 93% of the estimated Full S...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(99)00016-x
更新日期：1999-08-23 00:00:00
abstract：UNLABELLED:One important risk factor for cardiovascular disease is the metabolic syndrome (MS), yet limited data exist on its prevalence in US patients with schizophrenia. METHODS:Using baseline data from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Schizophrenia Trial, assessment of MS prev...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2005.07.014
更新日期：2005-12-01 00:00:00
abstract：:The aim of this paper is to provide a brief review of mitochondrial structure as it relates to function and then present abnormalities in mitochondria in postmortem schizophrenia with a focus on ultrastructure. Function, morphology, fusion, fission, motility, ΔΨmem, ATP production, mitochondrial derived vesicles, and ...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2017.01.056
更新日期：2017-09-01 00:00:00
abstract：OBJECTIVE:Reduced procreation among men with schizophrenia has been reported consistently when compared with female patients, but the cause is unknown. Reports on Caucasian individuals predominate in the published literature. Therefore, analyses were conducted concurrently among independent Indian and US samples in the...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2003.08.009
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND:There is increased interest in the impact of new long-acting treatments on health-related quality of life (HRQoL) in patients with schizophrenia. The aim of this study was to evaluate the impact of treatment with subcutaneous injections of RBP-7000, a new sustained-release formulation of risperidone, compare...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.schres.2016.03.020
更新日期：2016-07-01 00:00:00
abstract：:Forensic patients with schizophrenia who had carried out a homicide scored higher on a measure of moral cognition (MFQ-30) than other violent patients. Neurocognitive impairment was associated with homicide by mediation via higher scores for in-group loyalty. ...
journal_title：Schizophrenia research
pub_type： 信件
doi：10.1016/j.schres.2017.07.026
更新日期：2018-03-01 00:00:00
abstract：:Schizoaffective disorder is a common diagnosis in clinical practice but its nosological status has been subject to debate ever since it was conceptualized. Although it is key that diagnostic reliability is sufficient, schizoaffective disorder has been reported to have low interrater reliability. Evidence based on syst...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.schres.2016.07.012
更新日期：2016-10-01 00:00:00
abstract：:Large studies investigating the psychosocial effects of lifestyle interventions in patients with a severe mental illness (SMI) are scarce, especially in residential patients. This large, randomized controlled, multicentre pragmatic trial assessed the psychosocial effects of a combined diet-and-exercise lifestyle inter...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.schres.2018.02.053
更新日期：2018-09-01 00:00:00
abstract：:The dopamine (DA) hypothesis of schizophrenia stated that increased DA activity is the primary cause of schizophrenia. Recently, even though increased DA activity is in fact involved in psychotic symptoms and antipsychotic drug response, it has become clear that decreased DA activity is present in remitted and chronic...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/0920-9964(91)90032-m
更新日期：1991-03-01 00:00:00
abstract：BACKGROUND:Alterations in bone mineral density (BMD) in patients with psychotic disorder may reflect the effect of treatment (disease effect observed in patients but not their siblings) or, as an intermediate marker of cumulative endogenous estrogen exposure, alterations in the neuroprotective effect of estrogen in the...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.10.031
更新日期：2013-01-01 00:00:00
abstract：:The role of mentalizing abilities (or theory of mind) and empathic abilities in violent behavior were studied in 24 hospitalized males with paranoid schizophrenia (ICD-10). Patients were divided into violent and nonviolent groups based on their history of committing violent acts against others. To examine these abilit...
journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章
doi：10.1016/S0920-9964(03)00049-5
更新日期：2004-07-01 00:00:00
abstract：:Dopamine's proposed role in psychosis proved a starting point in our understanding of the neurobiology of relapse, fitting given the central role positive symptoms play. This link is reflected in early work examining neurotransmitter metabolite and drug (e.g. amphetamine, methylphenidate) challenge studies as a means ...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2013.10.009
更新日期：2014-02-01 00:00:00
abstract：INTRODUCTION:Emotion perception (EP) is impaired in schizophrenia, is stable across clinical state, resistant to antipsychotic treatment and linked to symptom severity. Given its pervasive nature, there is a need to quantitatively examine whether this dysfunction impacts functional outcomes. We used a meta-analytic str...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析
doi：10.1016/j.schres.2012.01.023
更新日期：2012-05-01 00:00:00
abstract：:Patients with schizophrenia often exhibit structural brain abnormalities, as well as neurological soft signs (NSS), consistent with its conceptualization as a neurodevelopmental disorder. NSS are mild, presumably nonlocalizing, neurological impairments that are inferred from performance deficits in domains such as sen...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.06.018
更新日期：2009-12-01 00:00:00
abstract：BACKGROUND:Mismatch negativity (MNN) and P3a are event related potential (ERP) measures of early sensory information processing. These components are usually conceptualized as being "pre-attentive" and therefore immune to changes with variations in attentional functioning. This study aimed to determine whether manipula...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.01.035
更新日期：2013-05-01 00:00:00
abstract：:The finding of pyramidal cell disarray in the hippocampus of patients with schizophrenia has been disputed by several groups. Conflicting results have been attributed to differences in the subtype of patients used, staining method, the side of the hippocampus studied and the way cellular disarray has been measured. In...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(01)00201-8
更新日期：2002-05-01 00:00:00
abstract：:Schizophrenia is characterized by increased mortality for which suicidality is the decisive factor. An analysis of cortical thickness and folding to further elucidate neuroanatomical correlates of suicidality in schizophrenia has not yet been performed. We searched for relevant brain regions with such differences betw...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.08.010
更新日期：2016-10-01 00:00:00
abstract：INTRODUCTION:Childhood abuse and neglect are risk factors for psychotic symptoms. Early adversities may contribute to alterations in neuro/social cognition, which in turn is associated with psychosis. This study explored the possible mediating/moderating role of neuro/social cognition between childhood abuse and neglec...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.11.028
更新日期：2019-04-01 00:00:00
abstract：:The influence of neurocognition, including general intelligence, on theory of mind (ToM) among patients with schizophrenia spectrum disorder is controversial. The purpose of the present study was to identify the influences of the non-ToM cognition and general intelligence on ToM performance in individuals at ultra-hig...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.06.019
更新日期：2013-09-01 00:00:00
