Abstract：
BACKGROUND:Several resting-state neuroimaging studies in schizophrenia indicate an excessive brain activity while others report an incoherent brain activity at rest. No direct evidence for the simultaneous presence of both excessive and incoherent brain activity has been established to date. Moreover, it is unclear whether unaffected siblings of schizophrenia patients who share half of the affected patient's genotype also exhibit the excessive and incoherent brain activity that may render them vulnerable to the development of schizophrenia. METHODS:27 pairs of schizophrenia patients and their unaffected siblings, as well as 27 healthy controls, were scanned using gradient-echo echo-planar imaging at rest. By using amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (Reho), we investigated the intensity and synchronization of local spontaneous neuronal activity in three groups. RESULTS:We observed that increased amplitude and reduced synchronization (coherence) of spontaneous neuronal activity were shared by patients and their unaffected siblings. The key brain regions with this abnormal neural pattern in both patients and siblings included the middle temporal, orbito-frontal, inferior occipital and fronto-insular gyrus. CONCLUSIONS:This abnormal neural pattern of excessive and incoherent neuronal activity shared by schizophrenia patients and their healthy siblings may improve our understanding of neuropathology and genetic predisposition in schizophrenia.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Liu C,Xue Z,Palaniyappan L,Zhou L,Liu H,Qi C,Wu G,Mwansisya TE,Tao H,Chen X,Huang X,Liu Z,Pu Wdoi
10.1016/j.schres.2016.01.022subject
Has Abstractpub_date
2016-03-01 00:00:00pages
158-65issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(16)30021-4journal_volume
171pub_type
杂志文章abstract：:Viral infections during fetal and adolescent periods, as well as during the course of schizophrenia itself have been linked to the onset and/or relapse of a psychosis. We previously reported that the unique antipsychotic aripiprazole, a partial D2 agonist, inhibits the release of tumor necrosis factor (TNF)-α from int...
journal_title：Schizophrenia research
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journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Schizophrenia research
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journal_title：Schizophrenia research
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journal_title：Schizophrenia research
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journal_title：Schizophrenia research
pub_type： 杂志文章
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更新日期：2014-01-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Schizophrenia research
pub_type： 杂志文章,评审
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更新日期：1999-03-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
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pub_type： 杂志文章,meta分析
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.03.030
更新日期：2018-09-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.12.036
更新日期：2020-04-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2008.01.020
更新日期：2008-04-01 00:00:00
abstract：OBJECTIVES:White matter (WM) abnormalities are one of the most widely and consistently reported findings in schizophrenia (SZ) and bipolar disorder (BD). If these abnormalities are inherited determinants of illness, suitable to be classified as an endophenotype, relatives of patients must also have them at higher rate ...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2014.12.008
更新日期：2015-02-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(89)90007-8
更新日期：1989-05-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(99)00072-9
更新日期：1999-10-19 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.05.021
更新日期：2013-08-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2006.02.020
更新日期：2006-06-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
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更新日期：2008-01-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析
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更新日期：2017-07-01 00:00:00
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pub_type： 杂志文章,多中心研究
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更新日期：2015-08-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(98)00113-3
更新日期：1999-01-04 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(01)00270-5
更新日期：2002-09-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2002-12-01 00:00:00
abstract：:Results of first-episode psychosis studies have shown that the diagnosis of schizophrenia is more stable across time than other diagnoses within the psychosis spectrum disorders. The objective of this study was to determine the diagnostic stability in a sample of first-episode patients and to determine the factors tha...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2006.04.018
更新日期：2006-09-01 00:00:00
abstract：:Evidence suggests that insight in psychosis has been related to treatment adherence, recovery and good prognosis, but also to depression, low self-esteem, and diminished quality of life. Thus, insight might not be advantageous under all circumstances. Internalized-stigma (i.e. self-acceptance of stigmatizing images of...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.03.010
更新日期：2015-05-01 00:00:00
