Abstract：
:Procedural learning (PL) is a type of rule-based learning in which performance facilitation occurs with practice on task without the need for conscious awareness. Schizophrenic patients have often (though not invariably) been found to show impaired PL. We performed functional magnetic resonance imaging (fMRI) during a blocked, periodic sequence-learning task with groups of: (i) healthy subjects, and (ii) schizophrenic patients on conventional antipsychotics. Healthy subjects showed significant PL, but patients did not. In healthy subjects, PL was associated with increased activation in the striatum, thalamus, cerebellum, precuneus, medial frontal lobe, and cingulate gyrus. The power of activation in the thalamus, striatum, precuneus, cingulate gyrus and BA 6 was related to the magnitude of PL in these subjects. No regions, except the anterior inferior gyrus, were significantly activated in patients. The caudate nucleus, thalamus, precuneus, and sensorimotor regions were activated significantly differently between the two groups. The findings demonstrate the involvement of the striatum, cerebellum, thalamus, cingulate gyrus, precuneus, and sensorimotor regions in PL. Further fMRI studies of PL in normal subjects treated with conventional antipsychotics, drug naïve patients, and patients given atypical antipsychotics would help to clarify the roles of schizophrenic disease processes and antipsychotic medication in impaired PL and associated brain abnormalities in schizophrenia.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Kumari V,Gray JA,Honey GD,Soni W,Bullmore ET,Williams SC,Ng VW,Vythelingum GN,Simmons A,Suckling J,Corr PJ,Sharma Tdoi
10.1016/s0920-9964(01)00270-5subject
Has Abstractpub_date
2002-09-01 00:00:00pages
97-107issue
1eissn
0920-9964issn
1573-2509pii
S0920996401002705journal_volume
57pub_type
杂志文章abstract：:The Scales of Cognitive Impairment Rated From Institutional Records (SCIRFIR), a battery based on commonly used dementia rating instruments, was tested on the records of 26 chronically institutionalized, elderly schizophrenia patients, for the purpose of retrospectively evaluating the long-term course of cognitive cha...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(98)00086-3
更新日期：1999-01-11 00:00:00
abstract：:In order to investigate a possible relationship between schizophrenic births and viral diseases, the birth month and year of all state hospital admissions for schizophrenia in Connecticut and Massachusetts from 1973-1974 were compared with the occurrence of reportable viral diseases for 1920-1955. Data was statistical...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(88)90043-6
更新日期：1988-01-01 00:00:00
abstract：BACKGROUND:Structural pathology in the hippocampus is well-documented in schizophrenia, but brain functional changes have not been consistently found. We used spatial navigation in a virtual reality environment, a task that is known to produce robust hippocampal activation in healthy subjects, to examine task-related a...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.02.033
更新日期：2016-04-01 00:00:00
abstract：:Schizophrenia constitutes a complex disease. Negative and cognitive symptoms are enduring and debilitating components of the disorder, highly associated to disability and burden. Disrupted neurotransmission circuits in dorsolateral prefrontal cortex (DLPFC) have been related to these symptoms. To identify candidates a...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.04.050
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:The concept of dose equivalence of depot medication is important for many scientific and clinical purposes. METHODS:A systematic literature search on four second-generation antipsychotics available as long-acting injectable drugs and haloperidol was conducted. We used the minimum effective dose method which...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2017.07.033
更新日期：2018-03-01 00:00:00
abstract：:Numerous studies indicate that social dysfunction is associated with negative symptoms of schizophrenia during the chronic phase of illness. However, it is unclear whether social abnormalities exist during the premorbid phase in people who later develop schizophrenia with prominent negative symptoms, or whether social...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2011.11.007
更新日期：2012-03-01 00:00:00
abstract：:We found previously that a subgroup of schizophrenic patients who passed screening tests of attentional competence showed memory deficits on word memory tasks, but were comparable with controls on tone memory tasks. To better understand the nature of language-specific memory deficits in this subgroup of patients, the ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(01)00194-3
更新日期：2002-01-15 00:00:00
abstract：BACKGROUND:Anomalies in visual and auditory perception represent an important aspect of the symptomatic manifestation of schizophrenia (ScZ). However, there are currently no instruments available that allow the assessment of the full range of auditory and visual abnormalities using a self-report measure. METHODS:We de...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.03.016
更新日期：2019-07-01 00:00:00
abstract：:Recovery from psychotic disorders includes both symptomatic and functional components. Progress in understanding recovery requires careful replication and extension of findings using comparable measures. In the current paper, we present a study of five year recovery rates in an early intervention program in London, Ca...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.08.054
更新日期：2018-05-01 00:00:00
abstract：:Microtubule associated proteins (MAPs) are central to the development of normal neuronal cytoarchitecture and have been reported to be altered in schizophrenia. In 12 schizophrenic (DSM-III-R criteria) and 12 control hippocampi, we estimated the MAP2 immunoreactive dendritic length using antibodies that recognize tota...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(99)00068-7
更新日期：2000-01-21 00:00:00
abstract：BACKGROUND:Higher liability to psychosis is associated with low self-esteem and increased sensitivity to social stress. Recently, we reported a positive relation between liability to psychosis and affective and psychotic responses to social stress. This study investigated how self-esteem moderates paranoia, peak subjec...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.06.042
更新日期：2018-12-01 00:00:00
abstract：:Negative symptoms can be grouped into the two dimensions of diminished expression and apathy, which have been shown to be dissociable regarding external validators, such as functional outcome. Here, we investigated whether these two dimensions differentially relate to neurocognitive impairment in schizophrenia. 47 pat...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.10.032
更新日期：2015-12-01 00:00:00
abstract：OBJECTIVE:Research participants must have adequate consent-related abilities to provide informed consent at the time of study enrollment. We sought to determine if research participants with schizophrenia maintain adequate consent-related abilities during a longitudinal study. If participants lose abilities during a tr...
journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.schres.2011.04.012
更新日期：2011-08-01 00:00:00
abstract：:Mismatch negativity (MMN) and P3a are auditory event-related potential (ERP) components that show robust deficits in schizophrenia (SZ) patients and exhibit qualities of endophenotypes, including substantial heritability, test-retest reliability, and trait-like stability. These measures also fulfill criteria for use a...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.schres.2014.09.042
更新日期：2015-04-01 00:00:00
abstract：OBJECTIVE:Quality of life (QOL) is considered an important outcome in the treatment of schizophrenia, but the determinants of QOL are poorly understood in this population. Furthermore, previous studies have relied on combined measures of subjective QOL (usually defined as life satisfaction) and objective QOL (usually d...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.09.001
更新日期：2008-01-01 00:00:00
abstract：:Numerous genetic and postmortem studies link N-methyl-d-aspartate receptor (NMDAR) dysfunction with schizophrenia, forming the basis of the popular glutamate hypothesis. Neuronal NMDAR abnormalities are consistently reported from both basic and clinical experiments, however, non-neuronal cells also contain NMDARs, and...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2020.10.004
更新日期：2020-11-11 00:00:00
abstract：BACKGROUND:Cognitive remediation (CR) aims primarily to improve cognition and functional outcomes. However, a limited number of studies reported a positive effect on symptoms. This limited effect may be because the symptom clusters considered are too broad and heterogeneous. This study explores, for the first time, the...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2014.03.032
更新日期：2014-06-01 00:00:00
abstract：:The 24-h profiles of plasma melatonin and cortisol were evaluated in 7 drug-free male paranoid schizophrenics and in 7 healthy subjects matched to the patients for age, sex, body weight, height and season of testing. Blood samples were obtained at 20.00, 22.00, 24.00, 01.00, 02.00, 06.00, 08.00 and 12.00 h. Light was ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(92)90077-i
更新日期：1992-04-01 00:00:00
abstract：:Stigma may undermine the well-being of young people at risk of psychosis. We therefore measured self-labeling, stigma variables and well-being at baseline and again one year later among 77 at-risk participants. An increase in self-labeling during this period predicted heightened stigma stress after one year and a decr...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.07.016
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND:Decreased callosal size and anisotropy have been described in schizophrenia patients but their longitudinal progression remains poorly understood. METHODS:We performed diffusion-tensor and structural magnetic resonance imaging at baseline and at follow-up four years later in 49 chronic schizophrenia patient...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.07.021
更新日期：2009-10-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to test the goodness-of-fit of all previously published five-factor models of the Positive and Negative Syndrome Scale (PANSS). METHODS:We used confirmatory factor analysis (CFA) with a large data set (N = 5769). RESULTS:The different subsamples were tested for heterogeneity and we...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2006.04.001
更新日期：2006-07-01 00:00:00
abstract：:Neuroanatomical abnormalities are considered to be related to the pathogenesis of schizophrenia. Reversal or reduction of normal structural cerebral asymmetries in schizophrenia is particularly striking. The current study investigated the alteration of gray matter volume and cerebral asymmetry in early stage of first-...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.05.021
更新日期：2013-08-01 00:00:00
abstract：INTRODUCTION:HTR2A gene has been the subject of numerous studies in psychiatric genetics because LSD, which resembles serotonin causes psychosis and atypical antipsychotic drugs target the HTR2A receptor. However, evidence for the role of HTR2A polymorphism(s) in schizophrenia (SCZ) and bipolar disorder (BD) has been e...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2011.04.007
更新日期：2011-07-01 00:00:00
abstract：INTRODUCTION:Widespread white matter abnormalities and alterations in glutamate levels have been reported in patients with schizophrenia. We hypothesized that alterations in white matter integrity and glutamate levels in individuals at clinical high risk (CHR) for psychosis are associated with the subsequent developmen...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2020.06.006
更新日期：2020-06-25 00:00:00
abstract：:Schizophrenia and affective disorders are relatively common neuropsychiatric diseases with a complex genetic etiology. A multigenic inheritance with variable influence of unknown environmental factors may be involved. Family studies have demonstrated the existence of both phenotypes in the same kindreds, and in certai...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/s0920-9964(99)00108-5
更新日期：1999-09-29 00:00:00
abstract：BACKGROUND:Functional remission (FR) is an intermediate and necessary step toward recovery, but is understudied in first-episode psychosis (FEP). We aimed to examine the rate and predictors of FR in FEP patients in the context of a randomized-controlled trial (RCT) comparing a 1-year extension of early intervention (Ex...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2016.03.016
更新日期：2016-05-01 00:00:00
abstract：:CACNA1C (12p13.3) has been implicated as a susceptibility gene for schizophrenia by several replicated genome wide association studies. While these results have been consistent among studies in European populations, the findings in East Asian populations have varied. To test whether CACNA1C is a risk gene for schizoph...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析
doi：10.1016/j.schres.2013.12.003
更新日期：2014-01-01 00:00:00
abstract：:Studies of the risk of schizophrenia and related non-affective psychoses among individuals exposed to head injury have reported conflicting findings. The diagnostic specificity of reported associations remains unclear and the effects of sex, genetic vulnerability and timing of exposures are also uncertain. The authors...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2006.07.001
更新日期：2006-12-01 00:00:00
abstract：:Executive functioning (EF) impairments are common in schizophrenia. There are two propositions regarding the causes of these impairments: (1) executive impairments are the result of the compounding effects of deficits in lower order cognitive skills (e.g. processing speed, attention) or (2) EF impairments exist in the...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.07.034
更新日期：2013-10-01 00:00:00
abstract：:Many children of a schizophrenic parent may inherit a portion of the genetic risk factors for schizophrenia. The frequency of DSM-IV psychopathology in children of a schizophrenic parent and the frequency and type of mental health treatment accessed by these youths is not well understood. Twenty-eight adults with schi...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(00)00043-8
更新日期：2001-05-30 00:00:00
