Abstract:
:To clarify the molecular mechanism of phencyclidine (PCP)-induced schizophreniform psychosis in humans and of behavioral abnormalities in experimental animals, we used differential screening of a cDNA library from the cerebral cortex of rats treated with PCP. We identified a PCP-induced cDNA clone as the gene encoding glutamate dehydrogenase (GDH), an enzyme central to glutamate metabolism. GDH mRNA levels significantly increased as early as 15 min following PCP administration in both the cerebral cortex and the cerebellum. This effect was observed even in the presence of a protein synthesis inhibitor, cycloheximide. In contrast to a transient increase in c-fos expression, the elevation of GDH mRNA levels lasted up to 8 days after a single PCP injection. These results suggest that GDH mRNA induction may be involved in the pathology of PCP-induced psychosis, and that GDH may be one of the candidate genes that are vulnerable in subjects with schizophrenia.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Shimizu E,Shirasawa H,Kodama K,Kuroyanagi H,Shirasawa T,Sato T,Simizu Bdoi
10.1016/s0920-9964(97)00029-7subject
Has Abstractpub_date
1997-06-20 00:00:00pages
251-8issue
3eissn
0920-9964issn
1573-2509pii
S0920996497000297journal_volume
25pub_type
杂志文章abstract::We tested the hypothesis that the expression of schizophrenic psychopathology is dependent on the stage of adolescent development. The study had a retrospective design, using high-quality case-note material of cases of schizophrenia at first admission. Patients with onset of illness between the age of 11 and 21 years ...
journal_title:Schizophrenia research
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abstract::Outcomes for people with schizophrenia-spectrum disorders (SSDs) are generally poor, making it important to understand risk states and illness transition. The network approach, which conceptualizes psychopathology as a network of causally interacting symptoms, may hold promise in this regard. Here, we present a networ...
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更新日期:2009-09-01 00:00:00
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更新日期:2019-02-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.12.008
更新日期:2011-04-01 00:00:00
abstract::Motivational deficits in patients with schizophrenia adversely affect various domains of daily living. This symptom in everyday life situations manifests in a complex behavioral pattern whose root cannot be simplified to an impaired reward-motivation scheme. This study aimed to identify impairment of the salience netw...
journal_title:Schizophrenia research
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更新日期:2018-07-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2008-02-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(99)00006-7
更新日期:1999-08-17 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/S0920-9964(97)00090-X
更新日期:1997-10-17 00:00:00
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pub_type: 杂志文章
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更新日期:1998-06-22 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2005.08.011
更新日期:2006-01-31 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(99)00068-7
更新日期:2000-01-21 00:00:00
abstract:BACKGROUND:The Positive and Negative Syndrome Scale (PANSS) total score is widely used to assess antipsychotic efficacy, however schizophrenia is a multi-dimensional disorder. We conducted a 5-factor analysis for evaluating the efficacy of iloperidone vs. placebo across these different domains in the treatment of schiz...
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pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2011.05.018
更新日期:2011-09-01 00:00:00
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journal_title:Schizophrenia research
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doi:10.1016/j.schres.2015.03.036
更新日期:2015-06-01 00:00:00
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doi:10.1016/j.schres.2010.03.012
更新日期:2010-07-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2012-05-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2007.12.489
更新日期:2008-04-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 信件
doi:10.1016/j.schres.2015.08.002
更新日期:2015-10-01 00:00:00
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doi:10.1016/j.schres.2006.07.005
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pub_type: 杂志文章,评审
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更新日期:2010-06-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2019.07.019
更新日期:2019-08-01 00:00:00
abstract::Recent advances in our understanding of the genetic architecture of schizophrenia have shed light on the schizophrenia etiology. While common variation is one of the major genetic contributors, the majority of common variation reside in non-coding genome, posing a significant challenge in understanding the functional ...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
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更新日期:2020-03-01 00:00:00
abstract::Large-scale gene expression studies in schizophrenia (SZ) have generally focused on the dorsolateral prefrontal cortex. Studies of other brain regions have been less frequent and have rarely been performed in the same subjects. We analyzed postmortem gene expression in multiple cortical regions (Brodmann areas 8, 10, ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2005.06.007
更新日期:2005-11-15 00:00:00
abstract::Despite robust evidence of neurocognitive dysfunction in psychotic patients, the degree of similarity in cognitive architecture across psychotic disorders and among their respective first-degree relatives is not well delineated. The present study examined the latent factor structure of the Brief Assessment of Cognitio...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.11.022
更新日期:2016-01-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.03.019
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:The intersect and blurring of boundaries between schizophrenia spectrum disorders and autism spectrum disorder (ASD) has long been an area of confusion, in both nosology and clinical practice. Individuals with a comorbid presentation of the two spectra can present with a distinct phenomenological profile to ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2019.11.037
更新日期:2020-02-01 00:00:00
abstract::We conducted data-mining analyses of genome wide association (GWA) studies of the CATIE and MGS-GAIN datasets, and found 13 markers in the two physically linked genes, PTPN21 and EML5, showing nominally significant association with schizophrenia. Linkage disequilibrium (LD) analysis indicated that all 7 markers from P...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2011.06.023
更新日期:2011-09-01 00:00:00