Abstract:
BACKGROUND:A false sense of reality is a characteristic of schizophrenia spectrum disorders (SSD). Reality confusion may also emanate from posterior orbitofrontal cortex (OFC) lesions, as evident in confabulations that patients act upon and disorientation. This confusion can be measured by repeated runs of a continuous recognition task (CRT): patients increase their false positive rate from the second run on, failing to realize that an item is not a repetition within the current run. Correct handling of these stimuli, a faculty called orbitofrontal reality filtering (ORFi), induces a distinct frontal potential at 200-300 ms, the "ORFi potential". Patients with schizophrenia have been reported to fail in this task, too. Here, we explored the electrophysiology of ORFi in SSD. METHODS:Evoked potentials, source, and connectivity analyses derived from high-density electroencephalograms of 17 patients with SSD and 15 age-matched healthy controls performing two runs of a CRT. RESULTS:Although the patients obtained normal performance, they did not normally express the frontal potential typical of ORFi between 200 and 300 ms. Coherence analysis demonstrated virtually absent functional connectivity in the theta band within the memory network in this period. Source analysis showed increased activity in left medial temporal and prefrontal regions in patients. CONCLUSIONS:SSD patients appear to invoke compensatory resources to handle the challenges of reality filtering. An abnormal ORFi potential may be an early biomarker of SSD.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Thézé R,Manuel AL,Pedrazzini E,Chantraine F,Patru MC,Nahum L,Guggisberg AG,Schnider Adoi
10.1016/j.schres.2018.07.036subject
Has Abstractpub_date
2019-02-01 00:00:00pages
214-221eissn
0920-9964issn
1573-2509pii
S0920-9964(18)30481-Xjournal_volume
204pub_type
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