当前位置： SCI文献检索 > SCHIZOPHRENIA RESEARCH期刊下所有文献 > Prevalence and outcomes of young people with concurrent autism spectrum disorder and first episode of psychosis.

Prevalence and outcomes of young people with concurrent autism spectrum disorder and first episode of psychosis.

Abstract：

BACKGROUND:The intersect and blurring of boundaries between schizophrenia spectrum disorders and autism spectrum disorder (ASD) has long been an area of confusion, in both nosology and clinical practice. Individuals with a comorbid presentation of the two spectra can present with a distinct phenomenological profile to those with psychosis or ASD alone. AIMS:To examine the prevalence rates of ASD in a cohort of young people presenting with a first episode of psychosis (FEP) and compare the demographic and clinical characteristics and functional outcomes between individuals with concurrent FEP and ASD, and individuals with FEP only. METHODS:Young people aged 15 to 24 who presented with FEP to the Early Psychosis Prevention and Intervention Centre (EPPIC) between 1st January 2011 and 31st December 2013 were included in the study. RESULTS:Of the 544 individuals presenting with a FEP, 3.7% (N = 20) had a diagnosis of ASD. Individuals with a concurrent diagnosis of FEP and ASD were more likely to be male and less likely to have comorbid substance use issues. There was no difference found in the severity of psychotic symptoms or diagnoses between groups. Those with FEP and ASD were more likely to experience impairments in interpersonal skills and be more likely to be engaged in employment or education at time of discharge from service. CONCLUSIONS:Individuals with concurrent FEP and ASD can present with distinct clinical characteristics that require specialised assessment and treatment. Further large-scale studies with control groups could help to better understand the phenomenological specificity of this subgroup.

journal_name

Schizophr Res

journal_title

Schizophrenia research

authors

Sunwoo M,O'Connell J,Brown E,Lin A,Wood SJ,McGorry P,O'Donoghue B

doi

10.1016/j.schres.2019.11.037

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

310-315

eissn

0920-9964

issn

1573-2509

pii

S0920-9964(19)30544-4

journal_volume

216

pub_type

杂志文章

相关文献

SCHIZOPHRENIA RESEARCH文献大全
  • Multiple site evaluation of P50 suppression among schizophrenia and normal comparison subjects.

    abstract：:Normally, when two brief, non-startling auditory stimuli are presented 500 ms apart, with long (e.g., 10 s) interpair intervals, the positive potential occurring approx. 50 ms after the first stimulus (P50) is relatively large, and the P50 to the second stimulus is smaller. In schizophrenia patients, however, the P50 ...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/s0920-9964(97)00122-9

    authors： Clementz BA,Geyer MA,Braff DL

    更新日期：1998-02-27 00:00:00

  • Grey matter networks in people at increased familial risk for schizophrenia.

    abstract：:Grey matter brain networks are disrupted in schizophrenia, but it is still unclear at which point during the development of the illness these disruptions arise and whether these can be associated with behavioural predictors of schizophrenia. We investigated if single-subject grey matter networks were disrupted in a sa...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2015.08.025

    authors： Tijms BM,Sprooten E,Job D,Johnstone EC,Owens DG,Willshaw D,Seriès P,Lawrie SM

    更新日期：2015-10-01 00:00:00

  • Caregiving processes and expressed emotion in psychosis, a cross-cultural, meta-analytic review.

    abstract：:The construct of Expressed Emotion (EE) is a reliable predictor of relapse in psychotic disorders globally. However, cultural differences in the level and manifestation of EE have been reported. This review was conducted in line with PRISMA guidelines to demonstrate the distribution of EE and its domains cross-cultura...

    journal_title：Schizophrenia research

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.schres.2019.03.020

    authors： O'Driscoll C,Sener SB,Angmark A,Shaikh M

    更新日期：2019-06-01 00:00:00

  • Elevated 3T proton MRS glutamate levels associated with poor Continuous Performance Test (CPT-0X) scores and genetic risk for schizophrenia.

    abstract：:Glutamate was quantified by proton magnetic resonance spectroscopy ((1)H-MRS) in the medial frontal lobes of 15 adult siblings of individuals with schizophrenia (HR) and 14 healthy volunteers (HV), all of whom also completed a Continuous Performance Test (CPT). Subjects were free of psychopathology but the HR group sh...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2007.11.028

    authors： Purdon SE,Valiakalayil A,Hanstock CC,Seres P,Tibbo P

    更新日期：2008-02-01 00:00:00

  • Novel rare variants in F-box protein 45 (FBXO45) in schizophrenia.

    abstract：:The ubiquitin ligase F-box protein 45 (FBXO45) is critical for synaptogenesis, neuronal migration, and synaptic transmission. FBXO45 is included in the 3q29 microdeletion region that confers a significant risk for schizophrenia, as shown by rare structural variant studies. Thus, FBXO45 is considered a prominent candid...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2014.04.032

    authors： Wang C,Koide T,Kimura H,Kunimoto S,Yoshimi A,Nakamura Y,Kushima I,Banno M,Kawano N,Takasaki Y,Xing J,Noda Y,Mouri A,Aleksic B,Ikeda M,Okada T,Iidaka T,Inada T,Iwata N,Ozaki N

    更新日期：2014-08-01 00:00:00

  • Obstetric factors, urbanization and psychosis.

    abstract：BACKGROUND:Epidemiologic evidence as early as the 1930s has suggested urbanization is linked to schizophrenia, either by place of admission, place of upbringing, or, more recently, place of birth. In the past decade, obstetric complications have been implicated in the etiology of schizophrenia. METHODS:With appropriat...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/s0920-9964(99)00152-8

    authors： Eaton WW,Mortensen PB,Frydenberg M

    更新日期：2000-06-16 00:00:00

  • Therapeutic effectiveness and tolerability of aripiprazole as initial choice of treatment in first episode psychosis in an early intervention service: A one-year outcome study.

    abstract：INTRODUCTION:Aripiprazole has been associated with a low prevalence of metabolic side effects as compared to other second generation antipsychotic (SGA) medications mostly in patients with long standing illness. The purpose of the present study was to assess specifically the effectiveness and safety of aripiprazole as ...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2016.04.036

    authors： Malla A,Mustafa S,Rho A,Abadi S,Lepage M,Joober R

    更新日期：2016-07-01 00:00:00

  • No evidence for structural brain changes in young adolescents at ultra high risk for psychosis.

    abstract：OBJECTIVE:The onset of psychosis is thought to be preceded by neurodevelopmental changes in the brain. However, the timing of these changes has not been established. We investigated structural brain changes in a sample of young adolescents (12-18 years) at ultra high-risk for psychosis (UHR). METHODS:Structural MRI da...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2009.04.013

    authors： Ziermans TB,Durston S,Sprong M,Nederveen H,van Haren NE,Schnack HG,Lahuis BE,Schothorst PF,van Engeland H

    更新日期：2009-07-01 00:00:00

  • Antipsychotic binding to the dopamine-3 receptor in humans: A PET study with [(11)C]-(+)-PHNO.

    abstract：BACKGROUND:All currently available antipsychotic medications bind to both the dopamine-2 (D2) and dopamine-3 (D3) receptors in vitro. However, there is conflicting evidence from in vivo studies about whether or not antipsychotic medications bind to the D3 receptor (D3R). The purpose of this study was to determine wheth...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2015.06.027

    authors： Girgis RR,Xu X,Gil RB,Hackett E,Ojeil N,Lieberman JA,Slifstein M,Abi-Dargham A

    更新日期：2015-10-01 00:00:00

  • Antipsychotic medication and remission of psychotic symptoms 10years after a first-episode psychosis.

    abstract：BACKGROUND:Several national guidelines recommend continuous use of antipsychotic medication after a psychotic episode in order to minimize the risk of relapse. However some studies have identified a subgroup of patients who obtain remission of psychotic symptoms while not being on antipsychotic medication for a period ...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2016.10.030

    authors： Wils RS,Gotfredsen DR,Hjorthøj C,Austin SF,Albert N,Secher RG,Thorup AA,Mors O,Nordentoft M

    更新日期：2017-04-01 00:00:00

  • Prediction of functional remission in first-episode psychosis: 12-month follow-up of the randomized-controlled trial on extended early intervention in Hong Kong.

    abstract：BACKGROUND:Functional remission (FR) is an intermediate and necessary step toward recovery, but is understudied in first-episode psychosis (FEP). We aimed to examine the rate and predictors of FR in FEP patients in the context of a randomized-controlled trial (RCT) comparing a 1-year extension of early intervention (Ex...

    journal_title：Schizophrenia research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.schres.2016.03.016

    authors： Chang WC,Kwong VW,Chan GH,Jim OT,Lau ES,Hui CL,Chan SK,Lee EH,Chen EY

    更新日期：2016-05-01 00:00:00

  • Examining the reliability and validity of the Clinical Assessment Interview for Negative Symptoms within the Management of Schizophrenia in Clinical Practice (MOSAIC) multisite national study.

    abstract：:The current study sought to expand on prior reports of the validity and reliability of the CAINS (CAINS) by examining its performance across diverse non-academic clinical settings as employed by raters not affiliated with the scale's developers and across a longer test-retest follow-up period. The properties of the CA...

    journal_title：Schizophrenia research

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.schres.2017.01.011

    authors： Blanchard JJ,Bradshaw KR,Garcia CP,Nasrallah HA,Harvey PD,Casey D,Csoboth CT,Hudson JI,Julian L,Lentz E,Nuechterlein KH,Perkins DO,Skale TG,Snowden LR,Tandon R,Tek C,Velligan D,Vinogradov S,O'Gorman C

    更新日期：2017-07-01 00:00:00

  • Effects of a lifestyle intervention on psychosocial well-being of severe mentally ill residential patients: ELIPS, a cluster randomized controlled pragmatic trial.

    abstract：:Large studies investigating the psychosocial effects of lifestyle interventions in patients with a severe mental illness (SMI) are scarce, especially in residential patients. This large, randomized controlled, multicentre pragmatic trial assessed the psychosocial effects of a combined diet-and-exercise lifestyle inter...

    journal_title：Schizophrenia research

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.schres.2018.02.053

    authors： Stiekema APM,Looijmans A,van der Meer L,Bruggeman R,Schoevers RA,Corpeleijn E,Jörg F

    更新日期：2018-09-01 00:00:00

  • The association between schizophrenia and the immune system: Review of the evidence from unbiased 'omic-studies'.

    abstract：:A role for immune processes in the pathogenesis of schizophrenia has been suggested by genetic and epidemiological studies, as well as cross-sectional studies on blood and brain samples. However, results are heterogeneous, which is likely caused by low samples sizes, insufficient control of confounders that influence ...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2019.05.028

    authors： van Mierlo HC,Schot A,Boks MPM,de Witte LD

    更新日期：2020-03-01 00:00:00

  • Differentiating patients with schizophrenia from healthy controls by hippocampal subfields using radiomics.

    abstract：BACKGROUND:Accurately diagnosing schizophrenia is still challenging due to the lack of validated biomarkers. Here, we aimed to investigate whether radiomic features in bilateral hippocampal subfields from magnetic resonance images (MRIs) can differentiate patients with schizophrenia from healthy controls (HCs). METHOD...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2020.09.009

    authors： Park YW,Choi D,Lee J,Ahn SS,Lee SK,Lee SH,Bang M

    更新日期：2020-09-01 00:00:00

  • Insight in early psychosis: a 1-year follow-up.

    abstract：:Insight was investigated in 180 individuals consecutively admitted to a comprehensive early psychosis treatment program. Insight was assessed on admission and after 3, 6 and 12 months. Insight improved significantly over 12 months, and was negatively correlated with both positive and negative symptoms, and positively ...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/S0920-9964(03)00047-1

    authors： Mintz AR,Addington J,Addington D

    更新日期：2004-04-01 00:00:00

  • Trait or state? A longitudinal neuropsychological evaluation and fMRI study in schizoaffective disorder.

    abstract：:Schizoaffective patients can have neurocognitive deficits and default mode network dysfunction while being acutely ill. It remains unclear to what extent these abnormalities persist when they go into clinical remission. Memory and executive function were tested in 22 acutely ill schizoaffective patients; they also und...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2014.08.017

    authors： Madre M,Radua J,Landin-Romero R,Alonso-Lana S,Salvador R,Panicali F,Pomarol-Clotet E,Amann BL

    更新日期：2014-11-01 00:00:00

  • Learning-related changes in brain activity following errors and performance feedback in schizophrenia.

    abstract：:In previous studies of self-monitoring in schizophrenia, patients have exhibited reductions in the amplitude of the error-related negativity (ERN), a component of the event-related brain potential (ERP) elicited most prominently immediately following the execution of incorrect responses. In the current study, we exami...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2007.08.027

    authors： Morris SE,Heerey EA,Gold JM,Holroyd CB

    更新日期：2008-02-01 00:00:00

  • Psychometric properties of the recovery measurement in homeless people with severe mental illness.

    abstract：OBJECTIVE:The Recovery Assessment Scale (RAS) is one of the most widely used measurements of recovery in mental health research. To date, no data have been available concerning the psychometric characteristics of the RAS in homeless people with severe mental illness. The aim of this study was to provide new data regard...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2015.10.007

    authors： Girard V,Tinland A,Mohamed EH,French Housing First Study Group.,Boyer L,Auquier P

    更新日期：2015-12-01 00:00:00

  • Outcome after discharge from an early psychosis program.

    abstract：:Studies defining the course and outcome of individuals experiencing their first episode (FE) of psychosis generally report an improvement in symptoms and functioning. Today, many FE patients are treated in specialized early psychosis programs. Little is known what happens to these individuals after discharge from thes...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2008.08.032

    authors： Addington J,Addington D

    更新日期：2008-12-01 00:00:00

  • High rates of comorbidity are found in childhood-onset schizophrenia.

    abstract：BACKGROUND:For adults with schizophrenia, comorbidity is common and contributes to impairment. Thus, there has been an increasing effort to identify and treat comorbid symptoms. This report extends that work by examining comorbidity in children and young adolescents with childhood-onset schizophrenia. METHODS:Eighty-t...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2006.07.006

    authors： Ross RG,Heinlein S,Tregellas H

    更新日期：2006-12-01 00:00:00

  • Clinical and demographic predictors of continuing remission or relapse following discontinuation of antipsychotic medication after a first episode of psychosis. A systematic review.

    abstract：BACKGROUND:Clinical guidelines recommend maintenance treatment with antipsychotic medication for one to two years following remission of symptoms after a first episode of psychosis. However, recent research has suggested that this may not be indicated. Consistent predictors of outcome would be beneficial to guide clini...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2017.11.010

    authors： Bowtell M,Ratheesh A,McGorry P,Killackey E,O'Donoghue B

    更新日期：2018-07-01 00:00:00

  • Studies of individuals with schizophrenia never treated with antipsychotic medications: a review.

    abstract：:A review of 65 studies of individuals with schizophrenia who had never been treated with antipsychotic medications indicates significant abnormalities in brain structure and function. Neurological and neuropsychological measures show the most consistent and largest group differences between those affected and normal c...

    journal_title：Schizophrenia research

    pub_type： 杂志文章,评审

    doi：10.1016/s0920-9964(02)00381-x

    authors： Torrey EF

    更新日期：2002-12-01 00:00:00

  • Neurocognitive performance in children aged 9-12 years who present putative antecedents of schizophrenia.

    abstract：BACKGROUND:We previously developed a novel method of identifying children aged 9-12 years who may be at elevated risk of developing schizophrenia and the spectrum disorders because they present a triad of putative antecedents of schizophrenia (ASz). The present study aimed to determine whether ASz children also present...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2010.05.034

    authors： Cullen AE,Dickson H,West SA,Morris RG,Mould GL,Hodgins S,Murray RM,Laurens KR

    更新日期：2010-08-01 00:00:00

  • Examining relationships between psychotic experiences and suicidal ideation in adolescents using a network approach.

    abstract：BACKGROUND:Suicide is one of the leading causes of death in young individuals. Timely and adequate identification of individuals with suicidal ideation could prevent from suicidal behavior. Psychotic experiences (PE) have been shown to increase levels of suicidal ideation (SI) in the general population. Therefore, deta...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2018.05.020

    authors： Núñez D,Fresno A,van Borkulo CD,Courtet P,Arias V,Garrido V,Wigman JTW

    更新日期：2018-11-01 00:00:00

  • Diminished modulation of motor cortical reactivity during context-based action observation in schizophrenia.

    abstract：BACKGROUND:Deficient mirror neuron system (MNS)-activity is associated with social cognition deficits in schizophrenia. However, it is not known how socio-emotional contexts modulate the MNS-response. In a Transcranial Magnetic Stimulation (TMS)-experiment, we aimed to compare putative MNS-responses to action observati...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2018.07.043

    authors： Bagewadi VI,Mehta UM,Naik SS,Govindaraj R,Varambally S,Arumugham SS,Naveen Kumar C,Thirthalli J

    更新日期：2019-02-01 00:00:00

  • Electoretinographic evidence of retinal ganglion cell-dependent function in schizophrenia.

    abstract：:Schizophrenia is a complex disorder that is diagnosed mainly with clinical observation and evaluation. Recent studies suggest that many people with schizophrenia have abnormalities in the function of the N-methyl-d-aspartate receptor (NMDAR). The retina is part of the central nervous system and expresses the NMDAR, ra...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2019.09.005

    authors： Moghimi P,Torres Jimenez N,McLoon LK,Netoff TI,Lee MS,MacDonald A 3rd,Miller RF

    更新日期：2020-05-01 00:00:00

  • No association of the Ser/Cys311 DRD2 molecular variant with schizophrenia using a classical case control study and the haplotype relative risk.

    abstract：:Arinami et al. (1994) reported an association between the Ser311/Cys311 variant of the DRD2 gene and schizophrenia in a Japanese population. We did not find statistically significant differences in the distribution of the allele frequencies between schizophrenics (103) and controls (97) in a case-control sample (chi 2...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/S0920-9964(97)00013-3

    authors： Verga M,Macciardi F,Pedrini S,Cohen S,Smeraldi E

    更新日期：1997-05-24 00:00:00

  • Interaction between parental psychosis and risk factors during pregnancy and birth for schizophrenia - the Northern Finland 1966 Birth Cohort study.

    abstract：:Our aim was to investigate the association between parental psychosis and potential risk factors for schizophrenia and their interaction. We evaluated whether the factors during pregnancy and birth have a different effect among subjects with and without a history of parental psychosis and whether parental psychosis ma...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2012.12.033

    authors： Keskinen E,Miettunen J,Koivumaa-Honkanen H,Mäki P,Isohanni M,Jääskeläinen E

    更新日期：2013-04-01 00:00:00

  • Postmortem studies on mitochondria in schizophrenia.

    abstract：:The aim of this paper is to provide a brief review of mitochondrial structure as it relates to function and then present abnormalities in mitochondria in postmortem schizophrenia with a focus on ultrastructure. Function, morphology, fusion, fission, motility, ΔΨmem, ATP production, mitochondrial derived vesicles, and ...

    journal_title：Schizophrenia research

    pub_type： 杂志文章,评审

    doi：10.1016/j.schres.2017.01.056

    authors： Roberts RC

    更新日期：2017-09-01 00:00:00