Abstract：
BACKGROUND:Epidemiologic evidence as early as the 1930s has suggested urbanization is linked to schizophrenia, either by place of admission, place of upbringing, or, more recently, place of birth. In the past decade, obstetric complications have been implicated in the etiology of schizophrenia. METHODS:With appropriate protections for anonymity, the files of the Danish Medical Birth Register were linked with the files of the Danish Psychiatric Case Register. The linkage produced 132 cases of schizophrenia and 69 cases of affective psychosis, who were born in 1973 or later, who entered a Danish psychiatric hospital before 1994. Controls were drawn from a 10% sample of the Medical Birth Register. Analysis was by logistic regression. RESULTS:The risk of hospitalization for schizophrenia was 4.20 times higher (95% CI=2.4-7.4) for those born in Copenhagen versus those born in rural areas of Denmark, and a linear relationship was demonstrated between urbanization of birthplace and risk. There was no difference in risk of hospitalization for affective psychosis for those born in Copenhagen versus rural areas. Obstetric complications had a moderate sized relationship to schizophrenia, but the relationship of urban birth to schizophrenia was unaffected by adjustment for obstetric complications. CONCLUSION:Urban birth is a strong risk factor for schizophrenia, not mediated by obstetric complications, which deserves further exploration.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Eaton WW,Mortensen PB,Frydenberg Mdoi
10.1016/s0920-9964(99)00152-8subject
Has Abstractpub_date
2000-06-16 00:00:00pages
117-23issue
2-3eissn
0920-9964issn
1573-2509pii
S0920-9964(99)00152-8journal_volume
43pub_type
杂志文章abstract：:Schizophrenia (SZ) is associated with broad burden. The clinical manifestations of SZ are related to pathophysiological alterations similar to what is seen in normal aging. Our aim was to evaluate the differences in telomere length (TL), a biomarker of cellular aging, in subjects with SZ (n=36), unaffected siblings (S...
journal_title：Schizophrenia research
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journal_title：Schizophrenia research
pub_type： 杂志文章
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更新日期：1997-10-17 00:00:00
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journal_title：Schizophrenia research
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doi：10.1016/j.schres.2009.04.013
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/j.schres.2015.10.032
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pub_type： 杂志文章
doi：10.1016/j.schres.2012.03.020
更新日期：2012-06-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.12.002
更新日期：2014-02-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.01.008
更新日期：2016-03-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2015-02-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2006.08.015
更新日期：2007-01-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(95)00089-5
更新日期：1996-05-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.04.001
更新日期：2012-07-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.12.036
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:While poor premorbid functioning is associated with poorer outcomes in psychotic illnesses, little is known about whether it is also a risk factor for suicide attempts. OBJECTIVE:The current study examined the association of premorbid functioning and suicide attempts in a county-wide cohort of first-admissi...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.11.005
更新日期：2010-02-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2004.05.009
更新日期：2005-06-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2005.05.014
更新日期：2005-10-15 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2006.07.006
更新日期：2006-12-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/s0920-9964(98)00065-6
更新日期：1998-09-07 00:00:00
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pub_type： 杂志文章
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更新日期：2010-08-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.07.036
更新日期：2019-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2014-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-04-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
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更新日期：2018-09-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.schres.2019.02.015
更新日期：2019-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.schres.2019.01.013
更新日期：2020-05-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析,评审
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更新日期：2016-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：1993-06-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1016/j.schres.2007.12.468
更新日期：2008-03-01 00:00:00
