Abstract:
:Schizophrenia (SZ) is associated with broad burden. The clinical manifestations of SZ are related to pathophysiological alterations similar to what is seen in normal aging. Our aim was to evaluate the differences in telomere length (TL), a biomarker of cellular aging, in subjects with SZ (n=36), unaffected siblings (SB, n=36) and healthy controls (HC, n=47). SZ had shorter TL compared to HC, but no difference was found in SB comparing to SZ. These findings indicate that a pathological accelerated aging profile could be present in the course of SZ and further studies are needed to confirm TL as potential endophenotype, especially in at risk populations.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Czepielewski LS,Massuda R,Panizzutti B,da Rosa ED,de Lucena D,Macêdo D,Grun LK,Barbé-Tuana FM,Gama CSdoi
10.1016/j.schres.2016.04.004subject
Has Abstractpub_date
2016-07-01 00:00:00pages
39-42issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(16)30135-9journal_volume
174pub_type
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pub_type: 杂志文章
doi:10.1016/j.schres.2016.02.033
更新日期:2016-04-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1996-07-05 00:00:00
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pub_type: 杂志文章
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.04.027
更新日期:2009-07-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2011.11.019
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pub_type: 杂志文章,随机对照试验
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更新日期:2010-08-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2019.09.016
更新日期:2020-05-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2020.06.032
更新日期:2020-09-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2019.05.028
更新日期:2020-03-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2009.03.029
更新日期:2009-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0920-9964(01)00184-0
更新日期:2002-05-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2003.08.007
更新日期:2004-04-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(02)00527-3
更新日期:2003-04-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.04.012
更新日期:2015-07-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/S0920-9964(03)00086-0
更新日期:2004-05-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.07.052
更新日期:2013-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.07.022
更新日期:2015-10-01 00:00:00
abstract::The natural history of neurocognitive impairments in schizophrenia is unclear. We aimed to characterise this in an epidemiological first-episode cohort and relate it to long-term outcome. All but 1 of 112 first-episode psychosis cases ascertained from a geographical catchment area were traced at 10-12 years. Neurocogn...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(03)00014-8
更新日期:2003-12-15 00:00:00
abstract:OBJECTIVE:Suicide is the leading cause of death in schizophrenia. An association between suicidal behavior and both higher and lower cognitive ability in schizophrenia has been reported. To clarify this relationship, we investigated whether the relationship between suicidality and neurocognition varied according to dif...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2012.06.017
更新日期:2012-09-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2017.08.057
更新日期:2018-05-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/s0920-9964(02)00381-x
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND:Previous studies have found increased prolactin concentrations in antipsychotic-naïve patients with schizophrenia. However, the roles of other hormones, and of potentially confounding variables such as gender and smoking, have not been considered. METHODS:Blood from newly diagnosed, antipsychotic-naïve pati...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2011.07.025
更新日期:2012-01-01 00:00:00