Abstract：
:Thirty-six subjects aged 16 years or older judged at risk for a first episode of psychosis within a North American multi-site study of the schizophrenia prodrome [McGlashan et al., Schizophr. Res. (2003); Miller et al., Schizophr. Res. (2003)] performed at levels intermediate to population norms and data reported for schizophrenia samples on a comprehensive neuropsychological exam. In the context of normal intelligence, this intermediate status suggests that, as a group, these subjects are not fully normal in neuropsychological functioning. Conversely, the finding that they do not show the levels of impairment commonly observed in schizophrenia, including within the first episode, suggests that prodromal interventions might conceivably prevent, delay, or lessen the severity of declines associated with first psychotic episodes.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Hawkins KA,Addington J,Keefe RS,Christensen B,Perkins DO,Zipurksy R,Woods SW,Miller TJ,Marquez E,Breier A,McGlashan THdoi
10.1016/j.schres.2003.08.007subject
Has Abstractpub_date
2004-04-01 00:00:00pages
115-22issue
2-3eissn
0920-9964issn
1573-2509pii
S0920996403002664journal_volume
67pub_type
杂志文章abstract：:Second generation antipsychotics cause derangements in glucose metabolism that are often interpreted as insulin resistance. In previous studies we have shown that this is not classical insulin resistance but the drugs were actually inducing a hyperglycaemic state associated with elevated hepatic glucose output (HGO) a...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.05.003
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:Self-referential processing (i.e. linking internal and external stimuli to one's own self) has received scant attention thus far in schizophrenia. This type of processing is a key component of social cognition and thought to be important for adaptive social functioning. Memory studies in healthy subjects hav...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2010.11.011
更新日期：2011-04-01 00:00:00
abstract：:Natural killer cell activity was prospectively studied in 15 patients with chronic schizophrenia and in seven patients with schizoaffective disorder, depressed type. These patients were compared to individually matched normal controls. No mean differences in natural killer cell activity between the patient groups and ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(92)90028-4
更新日期：1992-12-01 00:00:00
abstract：BACKGROUND:For adults with schizophrenia, comorbidity is common and contributes to impairment. Thus, there has been an increasing effort to identify and treat comorbid symptoms. This report extends that work by examining comorbidity in children and young adolescents with childhood-onset schizophrenia. METHODS:Eighty-t...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2006.07.006
更新日期：2006-12-01 00:00:00
abstract：:Evidence-based decisions on indicated prevention in early psychosis require large-scale studies on the pathways to care in high-risk subjects. EPOS (The European Prediction of Psychosis Study), a prospective multi-center, naturalistic field study in four European countries (Finland, Germany, The Netherlands and Englan...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.schres.2013.11.031
更新日期：2014-02-01 00:00:00
abstract：:Diminished expression is a diagnostic feature of a range of schizophrenia-spectrum disorders/conditions and is often unresponsive to treatment, is present across premorbid, first episode and various clinical states, and is considered a poor prognostic indicator. Surprisingly, little is known about diminished expressio...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.05.003
更新日期：2013-08-01 00:00:00
abstract：:Neuropsychological performance in 20 chronic schizophrenic patients was contrasted to 25 Parkinson's disease, 12 Huntington's disease patients and 26 normal controls on measures shown to be sensitive to subcortical dysfunction. Some overlap was observed in the performance of the schizophrenic and basal ganglia groups ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(95)00069-0
更新日期：1996-05-01 00:00:00
abstract：:Interleukin-1 beta, interleukin-6, tumor necrosis factor-alpha and the soluble interleukin-2 receptor were measured in the serum of 34 healthy controls and 48 patients with chronic schizophrenia using ELISA sandwich assays. No differences were found between the controls and patients. ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(95)00089-5
更新日期：1996-05-01 00:00:00
abstract：BACKGROUND:All currently available antipsychotic medications bind to both the dopamine-2 (D2) and dopamine-3 (D3) receptors in vitro. However, there is conflicting evidence from in vivo studies about whether or not antipsychotic medications bind to the D3 receptor (D3R). The purpose of this study was to determine wheth...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.06.027
更新日期：2015-10-01 00:00:00
abstract：:A motivation is a telling hallmark of negative symptomatology in schizophrenia, and it impacts nearly every facet of behavior, including inclination to attempt the difficult cognitive tasks involved in cognitive remediation therapy. Experiences of external reward, reinforcement, and hedonic anticipatory enjoyment are ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.08.001
更新日期：2010-05-01 00:00:00
abstract：:Several investigations suggest that complexin may be a schizophrenia-susceptibility factor. We conducted a genetic association analysis between complexin genes (CPLX1 and CPLX2) and schizophrenia in Japanese patients (377 cases and 341 controls). Ten and eleven haplotype-tagging (ht)SNPs in CPLX1 and CPLX2, respective...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2005.12.842
更新日期：2006-02-28 00:00:00
abstract：:Genetic and environmental models of neuropsychiatric disease have grown exponentially over the last 20years. One measure that is often used to evaluate the translational relevance of these models to human neuropsychiatric disease is prepulse inhibition of startle (PPI), an operational measure of sensorimotor gating. D...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2017.10.009
更新日期：2018-08-01 00:00:00
abstract：OBJECTIVE:To investigate the relationship between the four-facet model of PCL-R psychopathy and violence in a community-based sample of Australian men with schizophrenia-spectrum disorders. METHOD:A community sample of 94 males with schizophrenia-spectrum disorders was recruited from mental health services within Vict...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2011.09.010
更新日期：2012-04-01 00:00:00
abstract：BACKGROUND:Although altered gamma-aminobutyric acid (GABA) neurotransmission has been implicated in the pathophysiology of schizophrenia, it is unclear whether the influence of GABA on working memory processes is confounded by nicotine use in this population. It is therefore crucial to evaluate working memory and its u...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.01.008
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:Previous studies have shown that individuals with schizophrenia exhibit higher levels of unhelpful metacognitive beliefs than healthy controls, but no studies have explored metacognitive beliefs in early psychosis. AIMS:We examined i) differences in levels of unhelpful metacognitive beliefs between psychosi...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.schres.2015.10.026
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:A small but significant association between schizophrenia and violence is open to a number of explanations. Impaired empathy has been associated with schizophrenia, and with violence in the general population. Our aim was to conduct a systematic review of any research into relationships between schizophrenia...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2012.07.019
更新日期：2012-10-01 00:00:00
abstract：:The distribution of schizophrenia in families supports the hypothesis of heritable risk factors in schizophrenia, but there is as yet no identification of an inherited neurobiological defect. Human embryonic brain tissue fragments, derived from first trimester abortions, can be transplanted into rat hosts, where they ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(94)90051-5
更新日期：1994-10-01 00:00:00
abstract：OBJECTIVES:White matter (WM) abnormalities are one of the most widely and consistently reported findings in schizophrenia (SZ) and bipolar disorder (BD). If these abnormalities are inherited determinants of illness, suitable to be classified as an endophenotype, relatives of patients must also have them at higher rate ...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2014.12.008
更新日期：2015-02-01 00:00:00
abstract：:Mismatch negativity (MMN) and P3a are auditory event-related potential (ERP) components that show robust deficits in schizophrenia (SZ) patients and exhibit qualities of endophenotypes, including substantial heritability, test-retest reliability, and trait-like stability. These measures also fulfill criteria for use a...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.schres.2014.09.042
更新日期：2015-04-01 00:00:00
abstract：PURPOSE:Studies show that deficit syndrome schizophrenia patients, characterized by primary negative symptoms and poor functional outcome, have impairment in specific neural circuits. We assessed whether these same neural circuits are directly linked to functional outcomes across schizophrenia patients. METHODS:T1- an...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.10.023
更新日期：2015-12-01 00:00:00
abstract：:Increased rates of comorbid physical illness have been commonly reported in patients with schizophrenia. However, there are fewer data on dental disease in these patients. We systematically evaluated existing data on the oral health survey of schizophrenia patients through meta-analysis. Using the available databases,...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析
doi：10.1016/j.schres.2018.04.031
更新日期：2018-11-01 00:00:00
abstract：:In view of prior reports suggesting associations between polymorphisms of the tumor necrosis factor gene (TNF) and schizophrenia, we sequenced all exons, introns and 7 kb flanking sequence at TNF in DNA pooled from 125 Caucasian schizophrenia cases and 200 controls. We identified 18 SNPs of which we selected and genot...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2005.12.853
更新日期：2006-03-01 00:00:00
abstract：:Glutamate was quantified by proton magnetic resonance spectroscopy ((1)H-MRS) in the medial frontal lobes of 15 adult siblings of individuals with schizophrenia (HR) and 14 healthy volunteers (HV), all of whom also completed a Continuous Performance Test (CPT). Subjects were free of psychopathology but the HR group sh...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.11.028
更新日期：2008-02-01 00:00:00
abstract：INTRODUCTION:EEG power in the delta, theta and beta1 bands has been shown to be positively correlated with negative symptoms in first episode psychotic patients. The present study investigates this correlation in an "at risk mental state for psychosis" (ARMS) with the aim to improve prediction of transition to psychosi...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2010.08.031
更新日期：2010-11-01 00:00:00
abstract：:Glutamate transporters facilitate the buffering, clearance and cycling of glutamate and play an important role in maintaining synaptic and extrasynaptic glutamate levels. Alterations in glutamate transporter expression may lead to abnormal glutamate neurotransmission contributing to the pathophysiology of schizophreni...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.12.019
更新日期：2013-03-01 00:00:00
abstract：:The aim of the study was to assess changes in cortical thickness related to the use of n-3 polyunsaturated fatty acids (PUFA) as add-on therapy in patients with first episode schizophrenia. A double-blind randomized controlled study was conducted using a 26-week intervention composed of concentrated fish oil containin...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2017.10.013
更新日期：2018-05-01 00:00:00
abstract：:Haloperidol and reduced haloperidol plasma concentrations were measured in twelve schizophrenic patients upon cessation of haloperidol decanoate (HLD) treatment. Each patient received HLD 100 mg every 4 weeks for five injections. After the fifth injection, HLD was discontinued. Haloperidol and reduced haloperidol plas...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(93)90007-6
更新日期：1993-03-01 00:00:00
abstract：BACKGROUND:Altered motor behavior has consistently been reported in medication-naive adult patients with schizophrenia and first episode psychosis and adults at clinical high risk for psychosis (CHR). This study is the first to evaluate the prevalence of abnormal involuntary movements in a community sample of children ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.04.032
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:The number of antipsychotic prescriptions dispensed annually in England has increased substantially over the past decade. It is not known whether this is due to changes in prescribing practices, or an increase in the prevalence of psychosis. To our knowledge, no previous studies have investigated temporal tr...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2020.11.057
更新日期：2021-01-09 00:00:00
abstract：:Noises elicit startle blinks that are inhibited when immediately (approximately 100 ms) preceded by non-startling prepulses, perhaps reflecting automatic sensory gating. Startle blinks are facilitated when preceded by prepulses at longer lead intervals, perhaps reflecting strategic processes. Event-related brain poten...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(98)00148-0
更新日期：1999-05-25 00:00:00
