当前位置： SCI文献检索 > SCHIZOPHRENIA RESEARCH期刊下所有文献 > Validation of mismatch negativity and P3a for use in multi-site studies of schizophrenia: characterization of demographic, clinical, cognitive, and functional correlates in COGS-2.

Validation of mismatch negativity and P3a for use in multi-site studies of schizophrenia: characterization of demographic, clinical, cognitive, and functional correlates in COGS-2.

Abstract：

:Mismatch negativity (MMN) and P3a are auditory event-related potential (ERP) components that show robust deficits in schizophrenia (SZ) patients and exhibit qualities of endophenotypes, including substantial heritability, test-retest reliability, and trait-like stability. These measures also fulfill criteria for use as cognition and function-linked biomarkers in outcome studies, but have not yet been validated for use in large-scale multi-site clinical studies. This study tested the feasibility of adding MMN and P3a to the ongoing Consortium on the Genetics of Schizophrenia (COGS) study. The extent to which demographic, clinical, cognitive, and functional characteristics contribute to variability in MMN and P3a amplitudes was also examined. Participants (HCS n=824, SZ n=966) underwent testing at 5 geographically distributed COGS laboratories. Valid ERP recordings were obtained from 91% of HCS and 91% of SZ patients. Highly significant MMN (d=0.96) and P3a (d=0.93) amplitude reductions were observed in SZ patients, comparable in magnitude to those observed in single-lab studies with no appreciable differences across laboratories. Demographic characteristics accounted for 26% and 18% of the variance in MMN and P3a amplitudes, respectively. Significant relationships were observed among demographically-adjusted MMN and P3a measures and medication status as well as several clinical, cognitive, and functional characteristics of the SZ patients. This study demonstrates that MMN and P3a ERP biomarkers can be feasibly used in multi-site clinical studies. As with many clinical tests of brain function, demographic factors contribute to MMN and P3a amplitudes and should be carefully considered in future biomarker-informed clinical studies.

journal_name

Schizophr Res

journal_title

Schizophrenia research

authors

Light GA,Swerdlow NR,Thomas ML,Calkins ME,Green MF,Greenwood TA,Gur RE,Gur RC,Lazzeroni LC,Nuechterlein KH,Pela M,Radant AD,Seidman LJ,Sharp RF,Siever LJ,Silverman JM,Sprock J,Stone WS,Sugar CA,Tsuang DW,Tsuang MT

doi

10.1016/j.schres.2014.09.042

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

63-72

issue

1-3

eissn

0920-9964

issn

1573-2509

pii

S0920-9964(14)00534-9

journal_volume

163

pub_type

杂志文章,多中心研究

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