Natural killer cell activity in schizophrenia and schizoaffective disorder: a pilot study.

abstract：:Recent research on risk for psychosis has focused on youth who manifest subclinical signs that are often associated with the prodrome to psychosis. Standardized measures of prodromal symptoms have been shown to significantly enhance prediction of risk for conversion to an Axis I psychotic disorder. In the present stud...

journal_title：Schizophrenia research

authors： Simeonova DI,Attalla A,Trotman H,Esterberg M,Walker EF

更新日期：2011-08-01 00:00:00

abstract：:Deficits in nonverbal vocal expression (e.g., blunted vocal affect, alogia) are a hallmark of schizophrenia and are a focus of the Research Domain Criteria initiative from the National Institute of Mental Health. Results from studies using symptom rating scales suggest that these deficits are profound; on the order of...

journal_title：Schizophrenia research

authors： Cohen AS,Mitchell KR,Elvevåg B

更新日期：2014-11-01 00:00:00

abstract：:This is the first study to investigate whether positive family history (FH) of psychosis and affective disorders moderates the relationship between child diagnostic status and parent-reported social and behavioral problems on the Child Behavior Checklist (CBCL) in clinical high-risk adolescents. This longitudinal inve...

journal_title：Schizophrenia research

authors： Simeonova DI,Lee FJ,Walker EF

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:cortical gray matter volume deficit and ventricular enlargement are well documented in schizophrenia, but their presence in bipolar disorder is less well established. METHODS:global cortical gray matter, white matter and sulcal CSF, as well as lateral and third ventricular volume measures, were derived from...

journal_title：Schizophrenia research

authors： Lim KO,Rosenbloom MJ,Faustman WO,Sullivan EV,Pfefferbaum A

更新日期：1999-12-21 00:00:00

abstract：:Neurological Examination Abnormalities (NEA) are prevalent in schizophrenia, but the significance of this is obscured by methodological problems. The Neurological Evaluation Scale (NES), the most widely used structured neurological examination in schizophrenia research, has had limited study of its inter-rater reliabi...

journal_title：Schizophrenia research

authors： Sanders RD,Forman SD,Pierri JN,Baker RW,Kelley ME,Van Kammen DP,Keshavan MS

更新日期：1998-02-09 00:00:00

abstract：OBJECTIVE:To assess the prevalence and correlates of antipsychotic polypharmacy (APP) across decades and regions. METHODS:Electronic PubMed/Google Scholar search for studies reporting on APP, published from 1970 to 05/2009. Median rates and interquartile ranges (IQR) were calculated and compared using non-parametric t...

journal_title：Schizophrenia research

authors： Gallego JA,Bonetti J,Zhang J,Kane JM,Correll CU

更新日期：2012-06-01 00:00:00

abstract：:First episode psychosis (FEP) has been associated with structural brain changes, largely identified by volumetric analyses. Advances in neuroimaging processing have made it possible to measure geometric properties that may identify subtle structural changes not appreciated by a measure of volume alone. In this study w...

journal_title：Schizophrenia research

authors： Scanlon C,Anderson-Schmidt H,Kilmartin L,McInerney S,Kenney J,McFarland J,Waldron M,Ambati S,Fullard A,Logan S,Hallahan B,Barker GJ,Elliott MA,McCarthy P,Cannon DM,McDonald C

更新日期：2014-10-01 00:00:00

abstract：:Large-scale gene expression studies in schizophrenia (SZ) have generally focused on the dorsolateral prefrontal cortex. Despite a wealth of evidence implicating multiple other brain regions in the disease, studies of other brain regions have been less frequent and have rarely been performed in the same subjects. We an...

journal_title：Schizophrenia research

authors： Katsel P,Davis KL,Gorman JM,Haroutunian V

更新日期：2005-09-15 00:00:00

abstract：:An absent response to the niacin skin test has been reported to occur in about 80% of schizophrenic patients, as compared to 20% of healthy individuals. Niacin provokes redness in skin caused by a capillary vasodilatation mediated by prostaglandins. The metabolism of prostaglandins is regulated by the enzyme phospholi...

journal_title：Schizophrenia research

authors： Tavares H,Yacubian J,Talib LL,Barbosa NR,Gattaz WF

更新日期：2003-05-01 00:00:00

abstract：:Schizophrenia impairs both facial emotion processing and sustained attention. Through separate studies, it is known that the presence of a task-irrelevant facial stimulus disproportionately interferes with performance, whereas increasing the salience of task stimulus improves performance during a sustained attention t...

journal_title：Schizophrenia research

authors： Park SH,Noh JC,Kim JH,Lee J,Park JY,Lee YR,Kim CH,Lee KH

更新日期：2012-03-01 00:00:00

abstract：:Converging lines of evidence implicate structural and functional abnormalities in the cerebellum in schizophrenia (SCZ). The cerebellar vermis is of particular interest given its association with clinical symptoms and cognitive deficits in SCZ and its known connections with cortical regions such as the prefrontal cort...

journal_title：Schizophrenia research

authors： Womer FY,Tang Y,Harms MP,Bai C,Chang M,Jiang X,Wei S,Wang F,Barch DM

更新日期：2016-10-01 00:00:00

abstract：:Noises elicit startle blinks that are inhibited when immediately (approximately 100 ms) preceded by non-startling prepulses, perhaps reflecting automatic sensory gating. Startle blinks are facilitated when preceded by prepulses at longer lead intervals, perhaps reflecting strategic processes. Event-related brain poten...

journal_title：Schizophrenia research

authors： Ford JM,Roth WT,Menon V,Pfefferbaum A

更新日期：1999-05-25 00:00:00

abstract：:The purpose of the study was to examine the relationship between social anxiety and social functioning in first episode psychosis, and to determine whether those with psychosis have any maladaptive or irrational beliefs regarding social situations. A sample of 60 first episode patients (41 males, 19 females) participa...

journal_title：Schizophrenia research

authors： Voges M,Addington J

更新日期：2005-07-15 00:00:00

abstract：:Prenatal viral infection has been associated with development of schizophrenia and autism. Our laboratory has previously shown that viral infection causes deleterious effects on brain structure and function in mouse offspring following late first trimester (E9) administration of influenza virus. We hypothesized that l...

journal_title：Schizophrenia research

authors： Fatemi SH,Reutiman TJ,Folsom TD,Huang H,Oishi K,Mori S,Smee DF,Pearce DA,Winter C,Sohr R,Juckel G

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Individuals with schizophrenia tend to have low levels of physical activity (PA) which contributes to high rates of physical comorbidities. Valid and reliable methods of assessing PA are essential for advancing health research. Ten years after initial validation of the Short-Form International Physical Activ...

journal_title：Schizophrenia research

authors： Duncan MJ,Arbour-Nicitopoulos K,Subramanieapillai M,Remington G,Faulkner G

更新日期：2017-01-01 00:00:00

abstract：:Schizophrenia is associated with structural brain abnormalities that are likely to be present before disease onset. It remains unclear to what extent these represent general vulnerability indicators or are associated with the developing clinical state itself. It also remains unclear whether such state or trait alterat...

journal_title：Schizophrenia research

authors： Bois C,Levita L,Ripp I,Owens DCG,Johnstone EC,Whalley HC,Lawrie SM

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE:Recent years have witnessed growing interest in the role of the social environment in the development and outcomes of schizophrenia. We investigated whether neighborhood characteristics are associated with two important prognostic factors in early-course psychosis, age at onset of psychosis (AOP) and duration...

journal_title：Schizophrenia research

authors： Ku BS,Pauselli L,Manseau M,Compton MT

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:To explore the impact of the introduction of newer antipsychotic long-acting injections (LAIs) on trends in LAI prescribing and characteristics associated with initiation of LAIs in naturalistic conditions. METHODS:The study was performed using reimbursement data from the French Insurance Healthcare system. ...

journal_title：Schizophrenia research

authors： Verdoux H,Pambrun E,Tournier M,Bezin J,Pariente A

更新日期：2016-12-01 00:00:00

abstract：:Executive dysfunction and language impairment are the most prominent neuropsychological models of formal thought disorder (FTD) in schizophrenia. However, available studies have provided contradictory findings regarding the accuracy of these models. Furthermore, specific neurocognitive underpinnings of positive FTD (P...

journal_title：Schizophrenia research

authors： Bora E,Yalincetin B,Akdede BB,Alptekin K

更新日期：2019-07-01 00:00:00

abstract：:Pharmacological and genetic rodent models of schizophrenia play an important role in the drug discovery pipeline, but quantifying the molecular similarity of such models with the underlying human pathophysiology has proved difficult. We developed a novel systems biology methodology for the direct comparison of anterio...

journal_title：Schizophrenia research

authors： Cox DA,Gottschalk MG,Wesseling H,Ernst A,Cooper JD,Bahn S

更新日期：2016-11-01 00:00:00

abstract：:Schizophrenia is associated with poor quality of life (QOL). Whereas the effects of neurocognitive deficits and psychopathology on QOL of schizophrenia patients have recently been elucidated, little is known about social cognitive deficits in this regard. This study investigated the influence of social cognition on QO...

journal_title：Schizophrenia research

authors： Maat A,Fett AK,Derks E,GROUP Investigators.

更新日期：2012-05-01 00:00:00

abstract：:Although the concept of remission has been widely accepted and utilized in depression and anxiety disorders, there has been much less emphasis on defining remission in schizophrenia. Recently, an expert consensus definition of remission in schizophrenia was proposed along specific operational criteria for the attainme...

journal_title：Schizophrenia research

authors： Lasser RA,Nasrallah H,Helldin L,Peuskens J,Kane J,Docherty J,Tronco AT

更新日期：2007-11-01 00:00:00

abstract：:Language disturbance is one of the main diagnostic features in schizophrenia and abnormalities of brain language areas have been consistently found in schizophrenic patients. The main aim of this study was to describe the impairment of micro and macrolinguistic abilities in a group of twenty-nine schizophrenic patient...

journal_title：Schizophrenia research

authors： Marini A,Spoletini I,Rubino IA,Ciuffa M,Bria P,Martinotti G,Banfi G,Boccascino R,Strom P,Siracusano A,Caltagirone C,Spalletta G

更新日期：2008-10-01 00:00:00

abstract：:Schizophrenia is associated with subtle developmental compromise, but the degree to which this is also associated with heritability and genetic risk is uncertain. The goal of the current study was to investigate the childhood, adolescent, and early adulthood social and academic function of patients with schizophrenia,...

journal_title：Schizophrenia research

authors： Shapiro DI,Marenco S,Spoor EH,Egan MF,Weinberger DR,Gold JM

更新日期：2009-07-01 00:00:00

abstract：:Normally, when two brief, non-startling auditory stimuli are presented 500 ms apart, with long (e.g., 10 s) interpair intervals, the positive potential occurring approx. 50 ms after the first stimulus (P50) is relatively large, and the P50 to the second stimulus is smaller. In schizophrenia patients, however, the P50 ...

journal_title：Schizophrenia research

authors： Clementz BA,Geyer MA,Braff DL

更新日期：1998-02-27 00:00:00

abstract：:In 1873 Skeffington Lutwidge, a Lunacy Commission inspector of asylums in England, was killed by an asylum patient. Lutwidge was the uncle and close friend of Charles Lutwidge Dodgson, also known as Lewis Carroll. One year later, Carroll began writing The Hunting of the Snark, a poem whose meaning has mystified Carrol...

journal_title：Schizophrenia research

authors： Torrey EF,Miller J

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Activated immune-inflammatory pathways play an important role in the pathophysiology of schizophrenia. Paraoxonase 1 (PON1) activity is inversely associated with inflammatory responses in numerous clinical conditions. The aims of this study were to delineate serum arylesterase PON1 activity in drug-naïve fir...

journal_title：Schizophrenia research

authors： Brinholi FF,Noto C,Maes M,Bonifácio KL,Brietzke E,Ota VK,Gadelha A,Cordeiro Q,Belangero SI,Bressan RA,Vargas HO,Higachi L,de Farias CC,Moreira EG,Barbosa DS

更新日期：2015-08-01 00:00:00

abstract：:Previous studies have indicated that schizophrenic patients have olfactory deficits. The question as to whether olfactory deficits are due to chronic effects of medication has not been addressed. This is the first paper to report that never-medicated schizophrenic patients also have olfactory deficits. Twenty four nor...

journal_title：Schizophrenia research

authors： Wu J,Buchsbaum MS,Moy K,Denlea N,Kesslak P,Tseng H,Plosnaj D,Hetu M,Potkin S,Bracha S

更新日期：1993-03-01 00:00:00

abstract：:A case-control study was conducted in Singapore, in order to examine a proposed association between schizophrenia and the HLA DQB1 gene locus. The probands were male inpatients of Chinese ethnicity with schizophrenia (ICD-10 criteria, n = 102) and the controls were adults matched for gender and ethnicity (n = 111). Po...

journal_title：Schizophrenia research

authors： Nimgaonkar VL,Rudert WA,Zhang XR,Tsoi WF,Trucco M,Saha N

更新日期：1995-12-01 00:00:00

abstract：:Studies of neurocognitive function in patients with schizophrenia use widely variable assessment techniques. Clinical trials assessing the cognitive enhancing effect of new medications have used neurocognitive assessment batteries that differed in content, length and administration procedures. The Brief Assessment of ...

journal_title：Schizophrenia research

authors： Keefe RS,Goldberg TE,Harvey PD,Gold JM,Poe MP,Coughenour L

更新日期：2004-06-01 00:00:00