Abstract：
:Noises elicit startle blinks that are inhibited when immediately (approximately 100 ms) preceded by non-startling prepulses, perhaps reflecting automatic sensory gating. Startle blinks are facilitated when preceded by prepulses at longer lead intervals, perhaps reflecting strategic processes. Event-related brain potentials (ERPs) and startle blinks were used to investigate the well-documented prepulse inhibition failure in schizophrenia. Blinks and ERPs were recorded from 15 schizophrenic men and 20 age-matched controls to noises alone and to noises preceded by prepulses at 120 (PP120), 500 (PP500) and 4000 ms (PP4000) lead intervals. Neither blinks nor any of the ERP components elicited by the noise alone differentiated schizophrenics from controls, although responses to noises were modified by prepulses differently in the two groups. With the N1 component of the ERP, patients showed normal inhibition but lacked facilitation, and with P2, patients lacked inhibition, but showed normal facilitation. With reflex blinks and P300, inhibition was seen in both groups, but no facilitation. These results suggest that different neural circuits are involved in blink and cortical reflections of startle modification in schizophrenics and controls, with both automatic and strategic processes being impaired in schizophrenia.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Ford JM,Roth WT,Menon V,Pfefferbaum Adoi
10.1016/s0920-9964(98)00148-0subject
Has Abstractpub_date
1999-05-25 00:00:00pages
149-63issue
2eissn
0920-9964issn
1573-2509pii
S0920-9964(98)00148-0journal_volume
37pub_type
杂志文章abstract：BACKGROUND:Cognitive remediation (CR) aims primarily to improve cognition and functional outcomes. However, a limited number of studies reported a positive effect on symptoms. This limited effect may be because the symptom clusters considered are too broad and heterogeneous. This study explores, for the first time, the...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2014.03.032
更新日期：2014-06-01 00:00:00
abstract：:The current study examined the factor structure of the Brief Negative Symptom Scale (BNSS), a next-generation negative symptom rating instrument developed in response to the NIMH-sponsored Consensus Development Conference on Negative Symptoms. Participants included 146 individuals with a DSM-IV diagnosis of schizophre...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.09.007
更新日期：2012-12-01 00:00:00
abstract：:The degree of cortical atrophy as revealed by computed tomographic scans was assessed in 124 patients meeting the DSM III criteria for schizophrenia and in 45 age- and sex-matched healthy controls. 21 patients, i.e., 33% of the entire sample, showed moderate to severe atrophy. The presence of atrophy was not associate...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(88)90046-1
更新日期：1988-09-01 00:00:00
abstract：:Defeatist beliefs and amotivation are prominent obstacles in vocational rehabilitation for people with serious mental illnesses (SMI). The CBT-based Indianapolis Vocational Intervention Program (IVIP) was specifically designed to reduce defeatist beliefs related to work functioning. In the current study, we examined t...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.10.036
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:Prenatal micronutrient deficiency has been linked to later development of schizophrenia among offspring; however, no study has specifically investigated the association between vitamin A and this disorder. Vitamin A is an essential nutrient which is required by the early embryo and fetus for gene expression ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.02.004
更新日期：2012-05-01 00:00:00
abstract：:Early intervention strategies in psychosis would significantly benefit from the identification of reliable prognostic biomarkers. Pattern classification methods have shown the feasibility of an early diagnosis of psychosis onset both in clinical and familial high-risk populations. Here we were interested in replicatin...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.08.061
更新日期：2019-12-01 00:00:00
abstract：:A motivation is a telling hallmark of negative symptomatology in schizophrenia, and it impacts nearly every facet of behavior, including inclination to attempt the difficult cognitive tasks involved in cognitive remediation therapy. Experiences of external reward, reinforcement, and hedonic anticipatory enjoyment are ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.08.001
更新日期：2010-05-01 00:00:00
abstract：:Executive functioning (EF) impairments are common in schizophrenia. There are two propositions regarding the causes of these impairments: (1) executive impairments are the result of the compounding effects of deficits in lower order cognitive skills (e.g. processing speed, attention) or (2) EF impairments exist in the...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.07.034
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND:In schizophrenic psychoses, the normal sexual dimorphism of the brain has been shown to be disrupted or even reversed. Little is known, however, at what time point in emerging psychosis this occurs. We have therefore examined, if these alterations are already present in the at-risk mental state (ARMS) for ps...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.03.034
更新日期：2018-09-01 00:00:00
abstract：BACKGROUND:There is evidence that schizophrenia is a neuro-immune disorder. Genes linked to intragenic LINE-1 methylation show a strong association with immune-associated disorders including psychosis. The aim of this study was to examine LINE-1 methylation patterns in paranoid schizophrenia and methamphetamine-induced...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.02.015
更新日期：2019-06-01 00:00:00
abstract：OBJECTIVE:The use of dopaminergic antagonist antipsychotics is associated with hyperprolactinemia, but some studies have found increased prolactin concentrations in antipsychotic-naive patients with schizophrenia and related disorders. We conducted a systematic review and meta-analysis of studies of prolactin in antips...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.schres.2016.03.018
更新日期：2016-07-01 00:00:00
abstract：:The author previously proposed that schizophrenia has similar cytokine expression compared to melanoma, a neural crest cell tumor. One possible tumor model of schizophrenia includes anti-NMDA receptor encephalitis, a paraneoplastic syndrome. While examining the possible relationship of neural crest cell tumors to schi...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.08.012
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:Negative symptoms are a core feature of schizophrenia. The evolution and trajectory of primary negative symptoms were under-studied. We aimed at evaluating the prevalence and stability of primary negative symptoms, and factors associated with persistent primary negative symptoms in a first-episode sample. M...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2011.09.006
更新日期：2011-12-01 00:00:00
abstract：:Schizotypal personality disorder, a diagnosis defined partially in terms of a genetic relatedness to schizophrenia, has begun to receive extensive investigative study. While the exact etiologic relationship between schizotypal personality disorder and schizophrenia remains to be determined, three models have been cons...
journal_title：Schizophrenia research
pub_type：
doi：10.1016/s0920-9964(01)00363-2
更新日期：2002-03-01 00:00:00
abstract：:Many neuropsychological studies have described deficits of memory and executive functions in patients with schizophrenia, and the severity of these deficits seems to be determinant in predicting the community outcome of these patients [Schizophr. Bull. 26 (2000) 119]. However, neuropsychological evaluation does not pr...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2003.07.005
更新日期：2004-08-01 00:00:00
abstract：INTRODUCTION:Aripiprazole has been associated with a low prevalence of metabolic side effects as compared to other second generation antipsychotic (SGA) medications mostly in patients with long standing illness. The purpose of the present study was to assess specifically the effectiveness and safety of aripiprazole as ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.04.036
更新日期：2016-07-01 00:00:00
abstract：:Evidence suggests that insight in psychosis has been related to treatment adherence, recovery and good prognosis, but also to depression, low self-esteem, and diminished quality of life. Thus, insight might not be advantageous under all circumstances. Internalized-stigma (i.e. self-acceptance of stigmatizing images of...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.03.010
更新日期：2015-05-01 00:00:00
abstract：:Increased rates of comorbid physical illness have been commonly reported in patients with schizophrenia. However, there are fewer data on dental disease in these patients. We systematically evaluated existing data on the oral health survey of schizophrenia patients through meta-analysis. Using the available databases,...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析
doi：10.1016/j.schres.2018.04.031
更新日期：2018-11-01 00:00:00
abstract：:Catatonia is a severe psychomotor syndrome that frequently occurs in patients with schizophrenia spectrum disorders (SSD). Accumulating neuroimaging evidence suggests orbitofrontal, frontoparietal and cerebellar network dysfunction in catatonia. Very little is known about contributions of brainstem regions (as part of...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2020.09.025
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:All currently available antipsychotic medications bind to both the dopamine-2 (D2) and dopamine-3 (D3) receptors in vitro. However, there is conflicting evidence from in vivo studies about whether or not antipsychotic medications bind to the D3 receptor (D3R). The purpose of this study was to determine wheth...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.06.027
更新日期：2015-10-01 00:00:00
abstract：:Due to the limitations of analytical techniques and the complicity of schizophrenia, nowadays it is still a challenge to diagnose and stratify schizophrenia patients accurately. Many attempts have been made to identify and validate available biomarkers for schizophrenia from CSF and/or peripheral blood in clinical stu...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.03.009
更新日期：2020-12-01 00:00:00
abstract：:This study determines that visuospatial working memory (VSWM) deficits are evident in adolescent-onset schizophrenia, while the spatial strategy and spatial span components of VSWM are spared. These findings imply that frontal-striatal-parietal neural networks are dysfunctional in adolescent-onset schizophrenia, while...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2006.04.025
更新日期：2006-10-01 00:00:00
abstract：OBJECTIVE:Amoxapine is marketed as an antidepressant. However, its receptor occupancy, in vitro and in vivo, and its effects in pre-clinical models are very similar to atypical antipsychotics. To examine if this leads to an atypical antipsychotic effect in the clinical context, the authors examined the antipsychotic an...
journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章
doi：10.1016/s0920-9964(01)00342-5
更新日期：2003-01-01 00:00:00
abstract：:Although the seasonal patterns of admissions of affective disorder have been extensively studied, less attention has been given to the seasonal admission patterns of schizophrenia. The traditional method of aggregating the data over a study period, rather than analysing by year of admission may obscure potentially rel...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(98)00106-6
更新日期：1998-11-30 00:00:00
abstract：:In view of prior reports suggesting associations between polymorphisms of the tumor necrosis factor gene (TNF) and schizophrenia, we sequenced all exons, introns and 7 kb flanking sequence at TNF in DNA pooled from 125 Caucasian schizophrenia cases and 200 controls. We identified 18 SNPs of which we selected and genot...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2005.12.853
更新日期：2006-03-01 00:00:00
abstract：:Theory of mind (ToM) is the ability to understand mental states of others and it is crucial for building sensitivity to other persons or events. Measuring ToM is important for understanding and rehabilitating social cognitive impairments in persons with schizophrenia. The Social Attribution Task-Multiple Choice (SAT-M...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.06.022
更新日期：2018-11-01 00:00:00
abstract：:Although the concept of remission has been widely accepted and utilized in depression and anxiety disorders, there has been much less emphasis on defining remission in schizophrenia. Recently, an expert consensus definition of remission in schizophrenia was proposed along specific operational criteria for the attainme...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.05.003
更新日期：2007-11-01 00:00:00
abstract：:Though negative symptoms in schizophrenia are associated with a host of deleterious outcomes (e.g., White et al., 2009), not all individuals with schizophrenia suffer from negative symptoms (e.g., Blanchard et al., 2005). Thus, methods to quickly screen and identify patients for more intensive clinical interview asses...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2011.12.007
更新日期：2012-03-01 00:00:00
abstract：OBJECTIVE:Internalized stigma can lead to pervasive negative effects among people with severe mental illness (SMI). Although prevalence of internalized stigma is high, there is a dearth of interventions and meanwhile a lack of evidence as to their effectiveness. This study aims at unraveling the existence of different ...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.schres.2016.02.013
更新日期：2016-05-01 00:00:00
abstract：:Three-channel actometry was used to study neuroleptic-induced akathisia (NIA), a common and often serious disorder in association of traditional neuroleptic therapy. The aim was to explore the diagnostic possibilities of actometry in NIA and to examine in detail the motor phenomenology of the disorder in detail. The a...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(99)00045-6
更新日期：1999-11-30 00:00:00
