Abstract:
:Frontal lobe dysfunction in individuals with schizophrenia has frequently been detected using both neuroimaging and neuropsychological testing. Results from previous studies vary in the findings of regional specificity vs. generalized frontal cortical dysfunction. We sought to examine potential regional differences in frontal cortical functioning among patients with schizophrenia vs. a comparison group using two different neurocognitive tasks: the Gambling Task (GT) and the Wisconsin Card Sorting Test (WCST). In general, the GT is thought to reflect function of the ventromedial prefrontal cortex (VMPFC), while the WCST reflects function of the dorsolateral prefrontal cortex (DLPFC). Twenty individuals with schizophrenia or schizoaffective disorder and 15 nonpsychiatrically ill comparison subjects underwent an assessment battery consisting of the GT, WCST, and positive and negative symptom ratings. Patients with schizophrenia performed worse on the GT with respect to total monetary gain (p=0.05) and total monetary loss (p<0.05). They also preferred disadvantaged vs. advantaged cards (p<0.04). Surprisingly, WCST performance was poor in both groups and was not significantly different between groups. These findings are at some variance with those in the previously reported literature, but nonetheless support the idea that prefrontal cortical areas mediating different cognitive tasks may be distinguished by specific neurocognitive assessments.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Ritter LM,Meador-Woodruff JH,Dalack GWdoi
10.1016/S0920-9964(03)00086-0subject
Has Abstractpub_date
2004-05-01 00:00:00pages
65-73issue
1eissn
0920-9964issn
1573-2509pii
S0920996403000860journal_volume
68pub_type
杂志文章abstract::Long-stay patients constitute a small proportion of all patients with schizophrenia, but in both VA and state psychiatric systems these patients account for a majority of the costs associated with treatment of the illness. VA and state patients would be expected to differ in several respects, including age at onset an...
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abstract::Estrogen has been shown in animal studies to modulate both the dopamine and serotonin neurotransmitter systems - the main neurotransmitters implicated in the pathogenesis of schizophrenia. A double blind, 28 day, placebo-controlled study was conducted with three groups of women of child-bearing age (N=12 in each group...
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pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0920-9964(00)00088-8
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abstract:OBJECTIVE(S):To characterize the longitudinal patterns of antipsychotic treatment and to investigate the relationship between antipsychotic treatment patterns and acute hospitalizations among adults with schizophrenia. We hypothesized that continuous antipsychotic treatment would be associated with fewer hospitalizatio...
journal_title:Schizophrenia research
pub_type: 杂志文章
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更新日期:2008-04-01 00:00:00
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journal_title:Schizophrenia research
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更新日期:2012-03-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.09.010
更新日期:2011-03-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2018.05.020
更新日期:2018-11-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2015.04.006
更新日期:2015-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2019.01.046
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journal_title:Schizophrenia research
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2012-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/S0920-9964(96)00095-3
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(99)00016-x
更新日期:1999-08-23 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2005.02.012
更新日期:2005-07-15 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2007.04.026
更新日期:2007-08-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2005.07.009
更新日期:2005-12-15 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2016.12.012
更新日期:2017-07-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.07.001
更新日期:2009-10-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2017.05.011
更新日期:2018-02-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.07.034
更新日期:2013-10-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2011.04.007
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.01.035
更新日期:2013-05-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2004-10-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章
doi:10.1016/j.schres.2009.03.004
更新日期:2009-05-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.07.049
更新日期:2015-10-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2011.09.006
更新日期:2011-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.10.016
更新日期:2014-12-01 00:00:00
abstract::Attention Deficit/Hyperactivity Disorder (ADHD) is the most common psychiatric disorder in childhood. It is unclear whether ADHD increases the risk of non-affective psychotic disorder (NAPD). The study included a matched cohort, drawn from all born in Sweden 1987-1991 (n = 548,852). ADHD was defined as ICD diagnosis a...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2020.01.021
更新日期:2020-04-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2019.07.001
更新日期:2019-09-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.04.038
更新日期:2013-07-01 00:00:00
abstract::In order to investigate a possible relationship between schizophrenic births and viral diseases, the birth month and year of all state hospital admissions for schizophrenia in Connecticut and Massachusetts from 1973-1974 were compared with the occurrence of reportable viral diseases for 1920-1955. Data was statistical...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/0920-9964(88)90043-6
更新日期:1988-01-01 00:00:00