Abstract:
:In the last 25 years, the Positive and Negative Syndrome Scale (PANSS) has been largely used to assess schizophrenia symptom intensity, but little information is available on how this scale was generally applied when evaluating the efficacy of schizophrenia therapies in randomized clinical trials. In the attempt to address this topic, a systematic PubMed Search was carried out using the keywords "PANSS" and "Randomized Clinical Trials". The analysis of retrieved articles highlighted that PANSS has constituted a suitable psychometric instrument to investigate the efficacy of pharmacological and non-pharmacological therapies. However, the information potentially provided by this scale was only partially reported in research articles, when characterizing the symptomatic features of patients at baseline. Furthermore, a consensus is needed to identify methodological strategies that may properly adapt PANSS-subscale structure with the symptomatic profiles of individuals enrolled in randomized controlled trials. The possibility that PANSS interview procedures and enrollment eligibility criteria may influence the symptomatic composition of patients involved in these studies is also discussed.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Nicotra E,Casu G,Piras S,Marchese Gdoi
10.1016/j.schres.2015.04.006subject
Has Abstractpub_date
2015-07-01 00:00:00pages
181-7issue
2-3eissn
0920-9964issn
1573-2509pii
S0920-9964(15)00179-6journal_volume
165pub_type
杂志文章,评审abstract:BACKGROUND:Cannabis use may decrease age at onset in both schizophrenia and bipolar disorder, given the evidence for substantial phenotypic and genetic overlap between both disorders. METHODS:766 patients, aged 16 to 65 years, were assessed with the Composite International Diagnostic Interview (CIDI) for substance abu...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.07.003
更新日期:2011-03-01 00:00:00
abstract::The effects of stereotype suppression on psychiatric stigma were investigated in two studies. In experiment 1, 52 participants were presented with a photograph of someone labeled with schizophrenia and instructed to write a passage describing a day in that person's life. Half of the participants were instructed to avo...
journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2002-06-01 00:00:00
abstract::Three-channel actometry was used to study neuroleptic-induced akathisia (NIA), a common and often serious disorder in association of traditional neuroleptic therapy. The aim was to explore the diagnostic possibilities of actometry in NIA and to examine in detail the motor phenomenology of the disorder in detail. The a...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(99)00045-6
更新日期:1999-11-30 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2016.03.016
更新日期:2016-05-01 00:00:00
abstract::Studying Klinefelter syndrome (47,XXY), a genetically defined disorder characterized by the presence of an additional X chromosome, can reveal insights into genotype-phenotype associations. Increased vulnerability to psychiatric disorders characterized by difficulties in social interactions, such as schizophrenia and ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2006.02.020
更新日期:2006-06-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.schres.2016.04.013
更新日期:2016-07-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(01)00261-4
更新日期:2002-04-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章
doi:10.1016/0920-9964(96)82949-5
更新日期:1996-07-05 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2011.10.002
更新日期:2012-01-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析
doi:10.1016/j.schres.2014.12.031
更新日期:2015-03-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2004.05.021
更新日期:2005-03-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(99)00215-7
更新日期:2000-09-29 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2006.07.001
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:Little is known about the effects of antipsychotic medications on gray matter (GM) in schizophrenia. Although clozapine remains the most effective antipsychotic medication in treatment-refractory cases, it is unknown whether it has a differential effect on GM development. METHODS:In an exploratory analysis,...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.10.018
更新日期:2010-01-01 00:00:00
abstract::To clarify the molecular mechanism of phencyclidine (PCP)-induced schizophreniform psychosis in humans and of behavioral abnormalities in experimental animals, we used differential screening of a cDNA library from the cerebral cortex of rats treated with PCP. We identified a PCP-induced cDNA clone as the gene encoding...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(97)00029-7
更新日期:1997-06-20 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2018.01.007
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:Attentional deficits represent a core cognitive impairment in schizophrenia. The distractor condition Sustained Attention Task (dSAT) has been identified by the Cognitive Neuroscience Treatment to Improve Cognition in Schizophrenia (CNTRICS) initiative as a promising translational task for assessing schizophr...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.01.003
更新日期:2013-03-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2020.06.032
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:We updated our previous systematic review regarding clinical guidelines and algorithms on antipsychotic treatment in the maintenance phase of schizophrenia (doi: 10.1016/j.schres.2011.11.021) to incorporate and synthesize more recent findings to guide clinical practice. METHODS:We conducted a systematic lit...
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pub_type: 杂志文章
doi:10.1016/j.schres.2019.09.013
更新日期:2020-01-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.schres.2019.05.025
更新日期:2019-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0920-9964(03)00094-x
更新日期:2004-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0920-9964(92)90073-e
更新日期:1992-04-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.07.022
更新日期:2015-10-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2019.08.009
更新日期:2019-10-01 00:00:00
abstract::Aim Research regarding the effect of antipsychotic medications on the risk of upper respiratory infection (URI) progression to pneumonia in patients with schizophrenia is rare. This study investigated the effect of antipsychotic use on the risk of URI progression to pneumonia in patients with schizophrenia. METHODS:T...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2020.05.013
更新日期:2020-08-01 00:00:00
abstract::Postmortem studies have suggested that there is abnormal GABAergic activity in the hippocampus in schizophrenia (SZ). In micro-dissected human hippocampal slices, a loss of interneurons and a compensatory upregulation of GABAA receptor binding activity on interneurons, but not PNs, has suggested that disinhibitory GAB...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2015.01.014
更新日期:2015-09-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.11.011
更新日期:2011-04-01 00:00:00
abstract::Association with schizophrenia of the Abelson Helper Integration Site 1 (AHI1) gene on chromosome 6q23 and the adjacent primate-specific gene, C6orf217, was demonstrated in an inbred, Arab Israeli family sample and replicated in an Icelandic case control sample. Further support was provided by a second replication in ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.03.041
更新日期:2010-07-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(02)00310-9
更新日期:2003-03-01 00:00:00
abstract:BACKGROUND:Clozapine is the drug of choice for patients with unsatisfactory response to routine antipsychotic treatment. Polypharmacy is widely used among patients having clozapine-resistant schizophrenia, although no solid evidence exists for any effective augmentation therapy for this patient population. We aimed to ...
journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.schres.2009.01.002
更新日期:2009-04-01 00:00:00