Abstract：
OBJECTIVE:Attentional deficits represent a core cognitive impairment in schizophrenia. The distractor condition Sustained Attention Task (dSAT) has been identified by the Cognitive Neuroscience Treatment to Improve Cognition in Schizophrenia (CNTRICS) initiative as a promising translational task for assessing schizophrenia-related deficits in attentional selection-control, identifying neuroimaging biomarkers of such deficits, and for preclinical animal research on potential pro-cognitive treatments. Here, we examined whether patients would show specific difficulties in selection-control and in avoiding distraction in the dSAT. METHOD:Selection-control deficits are measured by comparing attentional performance in the Sustained Attention Task (SAT) without distraction to performance on the task when distraction is present (dSAT). The baseline SAT condition can also be used to assess time-on-task or vigilance effects. Patients with schizophrenia, age- and gender-matched healthy controls and, as an additional control, school-aged children were tested on both the SAT and dSAT. RESULTS:Compared to healthy controls, patients had reduced performance overall and were differentially vulnerable to distraction. In contrast, patients but not children had preserved vigilance over time. CONCLUSION:These results demonstrate specific input-selection control impairments in schizophrenia and suggest that patients' distraction-related impairments can be distinguished from general performance impairments and from deficits in other attentional processes (e.g., sustaining attention) evident in other groups.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Demeter E,Guthrie SK,Taylor SF,Sarter M,Lustig Cdoi
10.1016/j.schres.2013.01.003subject
Has Abstractpub_date
2013-03-01 00:00:00pages
136-41issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(13)00018-2journal_volume
144pub_type
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