Abstract：
:Schizophrenia is associated with significant impairments in both higher and lower order social cognitive performance and these impairments contribute to poor social functioning. People with schizophrenia report poor social functioning to be one of their greatest unmet treatment needs. Recent studies have suggested the potential of oxytocin as such a treatment, but mixed results render it uncertain what aspects of social cognition are improved by oxytocin and, subsequently, how oxytocin might best be applied as a therapeutic. The aim of this study was to determine whether a single dose of oxytocin improved higher-order and lower-order social cognition performance for patients with schizophrenia across a well-established battery of social cognition tests. Twenty-one male patients received both a single dose of oxytocin nasal spray (24IU) and a placebo, two weeks apart in a randomized within-subjects placebo controlled design. Following each administration, participants completed the social cognition tasks, as well as a test of general neurocognition. Results revealed that oxytocin particularly enhanced performance on higher order social cognition tasks, with no effects on general neurocognition. Results for individual tasks showed most improvement on tests measuring appreciation of indirect hints and recognition of social faux pas. These results suggest that oxytocin, if combined to enhance social cognition learning, may be beneficial when targeted at higher order social cognition domains. This study also suggests that these higher order tasks, which assess social cognitive processing in a social communication context, may provide useful markers of response to oxytocin in schizophrenia.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Guastella AJ,Ward PB,Hickie IB,Shahrestani S,Hodge MA,Scott EM,Langdon Rdoi
10.1016/j.schres.2015.06.005subject
Has Abstractpub_date
2015-11-01 00:00:00pages
628-33issue
3eissn
0920-9964issn
1573-2509pii
S0920-9964(15)00320-5journal_volume
168pub_type
杂志文章,随机对照试验abstract：:The watershed-hypothesis of schizophrenia asserts that over 200 different mutations dysregulate distinct pathways that converge on an unspecified common mechanism(s) that controls disease ontogeny. Consistent with this hypothesis, our RNA-sequencing of neuron committed cells (NCCs) differentiated from established iPSC...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.12.012
更新日期：2017-07-01 00:00:00
abstract：:An earlier age at onset of schizophrenia in men as opposed to women, has been widely reported, but hitherto, insufficient account has been taken of parameters that might confound this finding. Furthermore, few explanatory models have accounted for the differences in shape of the age-at-onset distributions in males and...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(98)00070-x
更新日期：1998-10-09 00:00:00
abstract：:Brain morphometry has been studied extensively in schizophrenic patients, and among the cortical differences identified two consistent findings are decreased cerebellar vermal volume and increased volume of the fourth ventricle; although contradictory findings are reported as well. Recent cognitive activation studies ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(98)00137-6
更新日期：1999-05-04 00:00:00
abstract：:Patients with schizophrenia often exhibit structural brain abnormalities, as well as neurological soft signs (NSS), consistent with its conceptualization as a neurodevelopmental disorder. NSS are mild, presumably nonlocalizing, neurological impairments that are inferred from performance deficits in domains such as sen...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.06.018
更新日期：2009-12-01 00:00:00
abstract：:Patients with schizophrenia exhibit impairments in prepulse inhibition (PPI) of the startle response. Available data suggest that atypical antipsychotics may be more effective than typical antipsychotics in improving PPI deficits in schizophrenia. However, previous studies have used between-subjects rather than longit...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.09.035
更新日期：2009-12-01 00:00:00
abstract：BACKGROUND:Cannabis and cocaine are the most common illicit drugs for which people are treated in addiction services in Latin America. Much research has suggested that the use of cannabis increases the risk of schizophrenia; there is less evidence concerning cocaine. The aim of the present study was to establish the re...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.04.010
更新日期：2018-04-01 00:00:00
abstract：OBJECTIVE:Attentional deficits represent a core cognitive impairment in schizophrenia. The distractor condition Sustained Attention Task (dSAT) has been identified by the Cognitive Neuroscience Treatment to Improve Cognition in Schizophrenia (CNTRICS) initiative as a promising translational task for assessing schizophr...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.01.003
更新日期：2013-03-01 00:00:00
abstract：:Existing literature on the neurocognitive correlates of community functioning in schizophrenia has not adequately focused on the relationships among the correlated variables. In a sample of 40 outpatients with schizophrenia and related disorders, we studied two sets of variables that we expected to be related to broad...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(01)00229-8
更新日期：2002-07-01 00:00:00
abstract：BACKGROUND:Cognitive Remediation (CR) is an evidence based treatment targeting cognitive and functional difficulties in people with psychosis. Despite the large number of effectiveness studies, only limited evidence exists for the active ingredients of this therapy. This study begins to fill this gap by exploring the r...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2017.09.012
更新日期：2019-01-01 00:00:00
abstract：:Evidence from event-related-potential (ERP) studies has repeatedly shown differences in the perception and processing of auditory stimuli in children with dyslexia compared to control children. The mismatch negativity (MMN) - an ERP component reflecting passive auditory change detection ability - has been found to be ...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2017.07.010
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:There is increased interest in the impact of new long-acting treatments on health-related quality of life (HRQoL) in patients with schizophrenia. The aim of this study was to evaluate the impact of treatment with subcutaneous injections of RBP-7000, a new sustained-release formulation of risperidone, compare...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.schres.2016.03.020
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:Noncompliance is common in patients with schizophrenia and can have serious consequences; therefore research of the variables associated with noncompliance is a priority. Although the MEMS device is regarded as the "reference standard" for evaluating compliance, it has been used in very few published studies...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2008.09.007
更新日期：2009-02-01 00:00:00
abstract：OBJECTIVE:Reduced procreation among men with schizophrenia has been reported consistently when compared with female patients, but the cause is unknown. Reports on Caucasian individuals predominate in the published literature. Therefore, analyses were conducted concurrently among independent Indian and US samples in the...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2003.08.009
更新日期：2004-06-01 00:00:00
abstract：:Around 1 in 5 children under 13 years old experience sub-clinical psychotic experiences (PEs) like hallucinations and delusions. While PEs in childhood are a significant risk factor for adult psychotic disorders, the majority of those experiencing childhood PEs do not develop a psychotic disorder. Individual differenc...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.08.022
更新日期：2020-01-01 00:00:00
abstract：:The functional integrity of the dorsolateral prefrontal cortex (DLPFC) is altered in schizophrenia leading to profound deficits in working memory and cognition. Growing evidence indicates that dysregulation of glutamate signaling may be a significant contributor to the pathophysiology mediating these effects; however,...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.09.022
更新日期：2007-12-01 00:00:00
abstract：:Characterizing a pattern of cognitive dysfunction in early onset schizophrenic patients may illuminate neurodevelopmental contributions to the illness. A cohort of chronically institutionalized schizophrenic patients with a variable range of age of onset (range 7-29 years) was administered a comprehensive battery of n...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(95)00065-8
更新日期：1996-05-01 00:00:00
abstract：BACKGROUND:Heterogeneity in clinical outcomes may be caused by factors working at multiple levels, e.g., between groups, between subjects, or within subjects over time. A more nuanced assessment of differences in variation among schizophrenia patients and between patients and healthy comparison subjects can clarify eti...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.10.033
更新日期：2013-01-01 00:00:00
abstract：:A sensitive radioimmunoassay was developed to determine the steady-state, fixed-dose pharmacokinetic profile of fluphenazine decanoate in nine outpatients. To see if neuroleptic blood levels measured by this assay correlated with a clinical event, we performed a cross-sectional study of fluphenazine blood levels in 11...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(88)90025-4
更新日期：1988-11-01 00:00:00
abstract：BACKGROUND:Current early screeners for psychosis-risk states have still to prove ability in identifying at-risk individuals. Among screeners, the 92-item Prodromal Questionnaire (PQ-92) is often used. We aimed to assess the validity of its Italian translation in a large Italian adolescent and young adult help-seeking s...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.02.008
更新日期：2017-11-01 00:00:00
abstract：:Although patients with schizophrenia have reduced brain size, there is no conclusive evidence that they have reduced head size. This begs the question: 'What is the precise relationship between head size and brain size?' We used a unique osteological collection to explore the relationship between external head measure...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(99)00098-5
更新日期：2000-03-16 00:00:00
abstract：:Microtubule associated proteins (MAPs) are central to the development of normal neuronal cytoarchitecture and have been reported to be altered in schizophrenia. In 12 schizophrenic (DSM-III-R criteria) and 12 control hippocampi, we estimated the MAP2 immunoreactive dendritic length using antibodies that recognize tota...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(99)00068-7
更新日期：2000-01-21 00:00:00
abstract：:Planning and executing goal-directed behaviours are critical final steps in translating motivation into action. Amotivation is a key feature of schizophrenia, but its impact on goal-directed functioning has not been extensively studied in an objective and ecologically valid manner. To address this, we investigated goa...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.10.012
更新日期：2019-04-01 00:00:00
abstract：:This randomized open-label study compared the incidence of metabolic side effects of aripiprazole, ziprasidone and quetiapine in a population of medication-naïve first-episode psychosis patients. A total of 202 subjects were enrolled. Body weight, body mass index, leptin, fasting lipids and fasting glycaemic parameter...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2014.07.045
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:Patients with schizophrenia show deviances in their dermatoglyphics, in particular reductions in palmar a-b ridge counts (ABRCs), which are evidence of an early developmental deviance. However, the severity or the origin of these ABRC changes has not been established. METHOD:(i) We examined the published li...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析
doi：10.1016/j.schres.2004.08.022
更新日期：2005-06-15 00:00:00
abstract：BACKGROUND:cortical gray matter volume deficit and ventricular enlargement are well documented in schizophrenia, but their presence in bipolar disorder is less well established. METHODS:global cortical gray matter, white matter and sulcal CSF, as well as lateral and third ventricular volume measures, were derived from...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(99)00063-8
更新日期：1999-12-21 00:00:00
abstract：:Mismatch negativity (MMN) and P3a are auditory event-related potential (ERP) components that show robust deficits in schizophrenia (SZ) patients and exhibit qualities of endophenotypes, including substantial heritability, test-retest reliability, and trait-like stability. These measures also fulfill criteria for use a...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.schres.2014.09.042
更新日期：2015-04-01 00:00:00
abstract：:In previous studies of self-monitoring in schizophrenia, patients have exhibited reductions in the amplitude of the error-related negativity (ERN), a component of the event-related brain potential (ERP) elicited most prominently immediately following the execution of incorrect responses. In the current study, we exami...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.08.027
更新日期：2008-02-01 00:00:00
abstract：:Procedural learning (PL) is a type of rule-based learning in which performance facilitation occurs with practice on task without the need for conscious awareness. Schizophrenic patients have often (though not invariably) been found to show impaired PL. We performed functional magnetic resonance imaging (fMRI) during a...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(01)00270-5
更新日期：2002-09-01 00:00:00
abstract：:The longitudinal course of primary cognitive dysfunction seen in schizophrenia has yet to be fully clarified. Whereas some studies in chronic patients have revealed a progressive decline in cognitive abilities, those studies with first-episode patients have indicated that initial cognitive deficits might remain stable...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2008.05.020
更新日期：2008-09-01 00:00:00
abstract：:Meta-analyses of randomized controlled trials support the efficacy of cognitive behavioral therapy (CBT) in the treatment of symptoms of schizophrenia refractory to antipsychotic medication. This article addresses the issue of medium term durability. A five-year follow-up was undertaken of a sample of 90 subjects who ...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2007.09.026
更新日期：2008-01-01 00:00:00
