Abstract:
:Patients with schizophrenia often exhibit structural brain abnormalities, as well as neurological soft signs (NSS), consistent with its conceptualization as a neurodevelopmental disorder. NSS are mild, presumably nonlocalizing, neurological impairments that are inferred from performance deficits in domains such as sensory integration, motor coordination, and motor sequencing. The vulnerability for schizophrenia is presumed to be expressed across a broad continuum of impairment referred to as schizotypy. It is hypothesized that nondisordered people along the schizotypy continuum should exhibit elevated rates of NSS. The present study examined the relation of psychometrically identified positive and negative schizotypy with NSS using the Neurological Evaluation Scale in a nonclinically ascertained sample of young adults (n=177). As hypothesized, negative, but not positive, schizotypy was related to increased NSS in tasks that assessed fine and gross motor coordination, motor sequencing, eye movement abnormalities, and memory recall. However, positive schizotypy was associated with increased NSS in tasks related to sensory integration dysfunction. In general, the positivexnegative schizotypy interaction term was unrelated to individual NSS tasks. The findings support: a) the theory that the vulnerability for schizophrenia is expressed across a broad continuum of subclinical and clinical impairment referred to as schizotypy; b) the multidimensional structure of schizotypy; and c) the notion that schizotypy is an appropriate construct for understanding the etiology and development of schizophrenia-spectrum disorders.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Kaczorowski JA,Barrantes-Vidal N,Kwapil TRdoi
10.1016/j.schres.2009.06.018subject
Has Abstractpub_date
2009-12-01 00:00:00pages
293-302issue
2-3eissn
0920-9964issn
1573-2509pii
S0920-9964(09)00293-Xjournal_volume
115pub_type
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更新日期:2013-04-01 00:00:00
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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更新日期:2015-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2012.03.020
更新日期:2012-06-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
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更新日期:2013-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
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更新日期:2015-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2007.11.018
更新日期:2008-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2002-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2017.11.010
更新日期:2018-07-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2016.09.010
更新日期:2017-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0920-9964(00)00123-7
更新日期:2001-04-15 00:00:00
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pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:1996-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2000-05-05 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2006.08.019
更新日期:2007-01-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/0920-9964(89)90032-7
更新日期:1989-07-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2018.06.042
更新日期:2018-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2007.06.001
更新日期:2007-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2018.03.034
更新日期:2018-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2009.03.017
更新日期:2009-06-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2018-09-01 00:00:00
abstract::Despite robust evidence of neurocognitive dysfunction in psychotic patients, the degree of similarity in cognitive architecture across psychotic disorders and among their respective first-degree relatives is not well delineated. The present study examined the latent factor structure of the Brief Assessment of Cognitio...
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pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00