Abstract：
BACKGROUND:cortical gray matter volume deficit and ventricular enlargement are well documented in schizophrenia, but their presence in bipolar disorder is less well established. METHODS:global cortical gray matter, white matter and sulcal CSF, as well as lateral and third ventricular volume measures, were derived from axial MRI brain images obtained on age-matched bipolar (n=9), schizophrenic (n=9), and control (n=16) subjects. All subjects were free of history of alcohol or other substance dependence. RESULTS:relative to controls, bipolar patients had widespread volume deficits of cortical gray matter but not of cortical white matter. Schizophrenic patients had an even more severe cortical gray matter deficit and greater sulcal and lateral ventricular enlargement than the bipolar patients. CONCLUSIONS:this group of patients with bipolar disorder had a widespread deficit of cortical gray matter similar to, but less pronounced than, that observed in patients with schizophrenia.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Lim KO,Rosenbloom MJ,Faustman WO,Sullivan EV,Pfefferbaum Adoi
10.1016/s0920-9964(99)00063-8subject
Has Abstractpub_date
1999-12-21 00:00:00pages
219-27issue
3eissn
0920-9964issn
1573-2509pii
S0920996499000638journal_volume
40pub_type
杂志文章abstract：BACKGROUND:Suicide and violence often co-occur in the general population as well as in mentally ill individuals. Few studies, however, have assessed whether these suicidal behaviors are predictive of violence risk in mental illness. AIMS:The aim of this study is to investigate whether suicidal behaviors, including sui...
journal_title：Schizophrenia research
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更新日期：2014-04-01 00:00:00
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journal_title：Schizophrenia research
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journal_title：Schizophrenia research
pub_type： 杂志文章
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更新日期：2016-11-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
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pub_type： 杂志文章,随机对照试验
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更新日期：2018-11-01 00:00:00
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journal_title：Schizophrenia research
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journal_title：Schizophrenia research
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journal_title：Schizophrenia research
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更新日期：2018-08-01 00:00:00
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更新日期：1994-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：2003-03-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.09.010
更新日期：2017-01-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章
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pub_type： 杂志文章
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更新日期：2007-12-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
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更新日期：2010-05-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章
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更新日期：1996-07-05 00:00:00
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journal_title：Schizophrenia research
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更新日期：2014-01-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章,评审
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更新日期：2015-09-01 00:00:00
