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Eye movement abnormalities and their association with cognitive impairments in schizophrenia.

Abstract：

BACKGROUND:Eye movement abnormalities have been identified in schizophrenia; however, their relevance to cognition is still unknown. In this study, we explored the general relationship between eye movements and cognitive function. METHODS:The three eye movement measures (scanpath length, horizontal position gain, and duration of fixations) that were previously reported to be useful in distinguishing subjects with schizophrenia from healthy subjects, as well as Wechsler Adult Intelligence Scale-III (WAIS-III) scores, were collected and tested for association in 113 subjects with schizophrenia and 404 healthy subjects. RESULTS:Scanpath length was positively correlated with matrix reasoning and digit symbol coding in subjects with schizophrenia and correlated with vocabulary and symbol search in healthy subjects. Upon testing for interaction effects of diagnosis and scanpath length on correlated WAIS-III scores, a significant interaction effect was only observed for matrix reasoning. The positive correlation between scanpath length and matrix reasoning, which was specific to subjects with schizophrenia, remained significant after controlling for demographic confounders such as medication and negative symptoms. No correlation was observed between the two other eye movement measures and any of the WAIS-III scores. CONCLUSIONS:Herein, we reveal novel findings on the association between eye-movement-based measures of visual exploration and cognitive scores requiring visual search in subjects with schizophrenia and in healthy subjects. The association between scanpath length and matrix reasoning, a measure of perceptual organization in subjects with schizophrenia, implies the existence of common cognitive processes, and subjects with longer scanpath length may be advantageous in performance of perceptual organization tasks.

journal_name

Schizophr Res

journal_title

Schizophrenia research

authors

Morita K,Miura K,Fujimoto M,Yamamori H,Yasuda Y,Kudo N,Azechi H,Okada N,Koshiyama D,Ikeda M,Kasai K,Hashimoto R

doi

10.1016/j.schres.2018.12.051

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

255-262

eissn

0920-9964

issn

1573-2509

pii

S0920-9964(18)30769-2

journal_volume

209

pub_type

杂志文章

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Eye movement abnormalities and their association with cognitive impairments in schizophrenia.