Abstract:
:Many neuropsychological studies have described deficits of memory and executive functions in patients with schizophrenia, and the severity of these deficits seems to be determinant in predicting the community outcome of these patients [Schizophr. Bull. 26 (2000) 119]. However, neuropsychological evaluation does not provide valuable information about how the cognitive deficits directly affect daily living, that is, which cognitive deficit affects which behavior. The present study aimed at determining whether executive dysfunction in schizophrenia could be directly measured by analyzing three activities of daily living (ADL), in addition to assessing the ecological validity of commonly used neuropsychological tests. Within specific ADL (choosing a menu, shopping the ingredients, cooking a meal), the sequences of behaviors that have been performed by 27 control subjects and 27 patients with schizophrenia were both analyzed by using a preset optimal sequence of behavior. When compared with control subjects, patients with schizophrenia showed more omissions when choosing the menu, more sequencing and repetitions errors during the shopping task, and more planning, sequencing, repetition and omission errors during the cooking task. These behavioral errors correlated significantly with negative, but not with positive symptoms of the patients. Furthermore, they also correlated with the poor performances on executive neuropsychological tests, especially those sensitive to shifting and sequencing abilities, but not with memory tests. These results suggest that executive deficits in schizophrenia may specifically affect ADL and that such deficits can be quantitatively assessed with a behavioral scale of action sequences.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Semkovska M,Bédard MA,Godbout L,Limoge F,Stip Edoi
10.1016/j.schres.2003.07.005subject
Has Abstractpub_date
2004-08-01 00:00:00pages
289-300issue
2-3eissn
0920-9964issn
1573-2509pii
S0920-9964(03)00243-3journal_volume
69pub_type
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journal_title:Schizophrenia research
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更新日期:2008-01-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2012.10.003
更新日期:2012-12-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.09.015
更新日期:2015-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0920-9964(92)90028-4
更新日期:1992-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2016.12.012
更新日期:2017-07-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2013.10.014
更新日期:2013-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2016.11.032
更新日期:2017-07-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.02.001
更新日期:2014-04-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2017.05.011
更新日期:2018-02-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2008.07.011
更新日期:2008-10-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2015-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2016.06.007
更新日期:2016-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:1998-10-09 00:00:00
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pub_type: 杂志文章
doi:10.1016/S0920-9964(03)00047-1
更新日期:2004-04-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.09.036
更新日期:2009-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0920-9964(99)00068-7
更新日期:2000-01-21 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.12.014
更新日期:2016-02-01 00:00:00
abstract::Genetic factors that modulate the immune response have been implicated as risk factors for schizophrenia and cognitive impairment. We assessed the correlation between cognitive functioning and the LTA Cys13Arg polymorphism in 351 individuals with schizophrenia, 122 with bipolar disorder, and 160 controls. There was a ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2006.08.015
更新日期:2007-01-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2017.08.054
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Schizophrenia is a disabling complex mental disorder and despite all available treatment, many patients unfortunately remain partial- or non-responders. A large body of research has shown that oxytocin is an important prosocial peptide and there is initial evidence that the central oxytocin system is altered...
journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2016.02.011
更新日期:2016-04-01 00:00:00