Abstract：
:In order to test the hypothesis that a poor performance in the Wisconsin test (WCST) may be an indicator of liability to schizophrenia, we compared the WCST performances of patients with DSM III-R schizophrenia, normal controls, and patients with schizotypal personality disorder (SZT PD). While schizophrenic patients performed significantly worse than subjects in the other two groups, schizotypal and normal subjects showed no significant differences in the WCST execution. Moreover, patients with SZT PD with or without positive family history for the schizophrenic spectrum had similar WCST performances. Our observations are in keeping with other studies employing the WCST in paradigms of heightened liability to schizophrenia, and suggest that a poor performance in the test is more probably a feature of the disease process, than a trait marker of vulnerability to the illness demonstrable in high-risk subjects.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Battaglia M,Abbruzzese M,Ferri S,Scarone S,Bellodi L,Smeraldi Edoi
10.1016/0920-9964(94)90007-8subject
Has Abstractpub_date
1994-12-01 00:00:00pages
39-45issue
1eissn
0920-9964issn
1573-2509pii
0920-9964(94)90007-8journal_volume
14pub_type
杂志文章abstract：:Cigarette smoking expectancies are systematically related to intention to quit smoking in adult smokers without psychiatric illness, but little is known about these relationships in smokers with serious mental illness. In this study, we compared positive and negative smoking expectancies, and examined relationships be...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.09.032
更新日期：2009-12-01 00:00:00
abstract：:repetitive thinking is often increased in various psychopathological conditions. However, evidence for its possible contribution to psychotic symptoms relies only on correlational analysis and has not been experimentally tested within the psychotic continuum. This research aims to examine whether repetitive thinking a...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.04.007
更新日期：2018-03-01 00:00:00
abstract：OBJECTIVE:Quality of life (QOL) is considered an important outcome in the treatment of schizophrenia, but the determinants of QOL are poorly understood in this population. Furthermore, previous studies have relied on combined measures of subjective QOL (usually defined as life satisfaction) and objective QOL (usually d...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.09.001
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVES:The impact of cannabis use on the brain tissue is still unclear, both in the healthy developing brain and in people with schizophrenia. The focus of this review is on white matter, the primary connective infrastructure of the brain. METHODS:We systematically reviewed diffusion tensor imaging (DTI) studies o...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2014.04.026
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND:A small but significant association between schizophrenia and violence is open to a number of explanations. Impaired empathy has been associated with schizophrenia, and with violence in the general population. Our aim was to conduct a systematic review of any research into relationships between schizophrenia...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2012.07.019
更新日期：2012-10-01 00:00:00
abstract：:We examined the fractionation of executive functioning performance in ninety patients with schizophrenia, who were tested for initiation, sustained attention, switching/flexibility, attention allocation and impulsivity/disinhibition. The participants were also given tests of general intelligence and memory. We analyse...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2005.08.011
更新日期：2006-01-31 00:00:00
abstract：BACKGROUND:Mismatch negativity (MNN) and P3a are event related potential (ERP) measures of early sensory information processing. These components are usually conceptualized as being "pre-attentive" and therefore immune to changes with variations in attentional functioning. This study aimed to determine whether manipula...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.01.035
更新日期：2013-05-01 00:00:00
abstract：OBJECTIVE:Patients with schizophrenia have a high prevalence of metabolic disorders and cardiovascular mortality. It is possible that a vulnerability to metabolic abnormalities is associated with risk for psychosis, symptoms and functionality. In this study, we evaluate demographic information, cardiometabolic indices,...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2018.09.022
更新日期：2019-02-01 00:00:00
abstract：:Recently, apolipoprotein D (apoD), a protein that is involved in the essential polyunsaturated fatty acid (EPUFA) transport and metabolism, and neuronal growth and regeneration was reported to have increased in the postmortem brain and decreased in the serum of schizophrenia patients. We studied the plasma apoD levels...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(01)00378-4
更新日期：2002-11-01 00:00:00
abstract：:Large-scale gene expression studies in schizophrenia (SZ) have generally focused on the dorsolateral prefrontal cortex. Despite a wealth of evidence implicating multiple other brain regions in the disease, studies of other brain regions have been less frequent and have rarely been performed in the same subjects. We an...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2005.03.020
更新日期：2005-09-15 00:00:00
abstract：:NRG1 is one of the most researched genes associated with schizophrenia. Although three meta-analyses in this area have been published, the results have been inconclusive and even conflicting. Family based studies can be problematical due to the difficulty of synthesizing them with case-control studies. Heterogeneity i...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.03.017
更新日期：2009-06-01 00:00:00
abstract：:In 200 inpatients on regular neuroleptics, point prevalence of extrapyramidal syndromes, including Parkinson syndrome, akathisia and tardive dyskinesia (TD), was studied and found to be 20, 11 and 22%, respectively. A total of 46 patients have currently, and for a longer time, (average about 3years, median over 1year)...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(99)00133-4
更新日期：2000-05-05 00:00:00
abstract：:The MATRICS Consensus Cognitive Battery (MCCB) was developed to assess cognitive treatment effects in schizophrenia clinical trials, and is considered the FDA gold standard outcome measure for that purpose. The aim of the present study was to establish pre-treatment psychometric characteristics of the MCCB in a large ...
journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章
doi：10.1016/j.schres.2017.03.040
更新日期：2017-12-01 00:00:00
abstract：:Forensic patients with schizophrenia who had carried out a homicide scored higher on a measure of moral cognition (MFQ-30) than other violent patients. Neurocognitive impairment was associated with homicide by mediation via higher scores for in-group loyalty. ...
journal_title：Schizophrenia research
pub_type： 信件
doi：10.1016/j.schres.2017.07.026
更新日期：2018-03-01 00:00:00
abstract：:A recent single-site study (Fisher et al., 2009. Am J Psychiatry. 166 (7) 805-11) showed that repeated training with the Brain Fitness Program (BFP) improved performance on a battery of neuropsychological tasks. If replicated these data suggest an important non-pharmacological method for ameliorating cognitive impairm...
journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.schres.2012.01.042
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND:Despite the upsurge of research regarding cognitive impairment in schizophrenia we still lack adequate understanding of the executive functioning of patients in symptomatic remission. Moreover, the cognitive functioning of patients in partial remission has not been studied previously although they comprise a...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.10.011
更新日期：2012-12-01 00:00:00
abstract：:Jumping to conclusions and bias against disconfirmatory evidence are two cognitive biases common in people with psychotic-like experiences and psychosis. However, many participants show comprehension problems doing traditional tasks; new paradigms with additional applied scenarios are thus needed. A large MTurk commun...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.12.016
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Superior temporal gyrus (STG/BA22) volume is reduced in schizophrenia and to a milder degree in schizotypal personality disorder (SPD), representing a less severe disorder in the schizophrenia spectrum. SPD and Borderline personality disorder (BPD) are severe personality disorders characterized by social and...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.04.027
更新日期：2009-07-01 00:00:00
abstract：:Noises elicit startle blinks that are inhibited when immediately (approximately 100 ms) preceded by non-startling prepulses, perhaps reflecting automatic sensory gating. Startle blinks are facilitated when preceded by prepulses at longer lead intervals, perhaps reflecting strategic processes. Event-related brain poten...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(98)00148-0
更新日期：1999-05-25 00:00:00
abstract：:Genetic epidemiological studies have demonstrated markedly reduced rates in reproduction among schizophrenic patients. According to evolutionary theory, behavioral and psychological phenotypes are selected based on ecological "fit". Where differential survival or reproductive success exists, genotype frequencies are a...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(00)00062-1
更新日期：2001-03-01 00:00:00
abstract：:The nucleus accumbens (NAcc) is often implicated in schizophrenia (SZ) pathology, but with little evidence to support its role. This study examined postmortem human tissue to determine if abnormalities are present in the dopaminergic or glutamatergic systems in the NAcc in SZ. We compared the protein levels of tyrosin...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.08.041
更新日期：2015-12-01 00:00:00
abstract：:Patients with schizophrenia did not take significantly more trials than normal controls to learn to use a visual warning signal to avoid a non-aversive stimulus on a simple computer-administered avoidance learning task. When the stimulus to be avoided was aversive (i.e., a loud buzzer), however, the schizophrenic grou...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(98)00181-9
更新日期：1999-07-27 00:00:00
abstract：:In order to investigate a possible relationship between schizophrenic births and viral diseases, the birth month and year of all state hospital admissions for schizophrenia in Connecticut and Massachusetts from 1973-1974 were compared with the occurrence of reportable viral diseases for 1920-1955. Data was statistical...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(88)90043-6
更新日期：1988-01-01 00:00:00
abstract：BACKGROUND:Psychotic-like experiences (PLEs) during adolescence are not uncommon and potentially represent a clinical and public health concern. A greater understanding of their aetiology and patterns of change over time is needed. We aimed to describe trajectories of PLEs during adolescence, and examine their associat...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.06.024
更新日期：2012-09-01 00:00:00
abstract：BACKGROUND:Family studies have suggested that schizophrenia and bipolar disorders share some susceptibility factors. Schizotypal personality disorder (SPD) may be an intermediate phenotype common both to schizophrenia and bipolar disorders. We explored the familiality of schizotypal dimensions by comparing the magnitud...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2005.07.009
更新日期：2005-12-15 00:00:00
abstract：:Attention deficits are considered to be fundamental in patients with schizophrenia. During attention tasks, patients with schizophrenia have been shown to display increased brain activity in some neuroimaging studies but reduced brain activity in others. These conflicting findings may be due to some study designs prim...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2010.03.019
更新日期：2010-09-01 00:00:00
abstract：BACKGROUND:D-serine is an allosteric modulator of the brain N-methyl-d-aspartate (NMDA) receptor and a potential novel treatment of schizophrenia. Double-blind studies have been performed at 30 mg/kg/day (approximately 2 g/day) with encouraging results, but no formal dose escalation studies have been performed. We desc...
journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章
doi：10.1016/j.schres.2010.05.012
更新日期：2010-08-01 00:00:00
abstract：INTRODUCTION:HTR2A gene has been the subject of numerous studies in psychiatric genetics because LSD, which resembles serotonin causes psychosis and atypical antipsychotic drugs target the HTR2A receptor. However, evidence for the role of HTR2A polymorphism(s) in schizophrenia (SCZ) and bipolar disorder (BD) has been e...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2011.04.007
更新日期：2011-07-01 00:00:00
abstract：:Specialized First Episode Psychosis (FEP) services have been conceptualized in part around the issue of engagement. Creating treatment that is easier to access, with more frequent contacts, assertive outreach to clients between appointments, and an explicit youth-oriented culture could make services more attractive to...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.08.035
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:The long-term evolution of neuroleptic-induced extrapyramidal syndromes (EPS) of Parkinsonism, akathisia and tardive dyskinesia (TD) is still a controversial issue worth exploring. METHOD:A total of 200 inpatients on regular typical neuroleptics (NL) and/or clozapine were assessed in 1995 with regard to the...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.10.018
更新日期：2008-03-01 00:00:00
