Abstract:
:NRG1 is one of the most researched genes associated with schizophrenia. Although three meta-analyses in this area have been published, the results have been inconclusive and even conflicting. Family based studies can be problematical due to the difficulty of synthesizing them with case-control studies. Heterogeneity is another persistently difficult problem which tends to be side-stepped in genetic studies. To deal with these points, we performed a meta-analysis of 26 published case-control and family-based association studies up to September 2008 covering 8049 cases, 8869 controls and 1515 families. The matrix of coancestry coefficient was also calculated using population genetics. Across these studies, the conclusions are as follows: Firstly, only SNP8NRG221132, 420M9-1395(0) and 478B14-848(0) showed significant association in the relatively small sample size. Secondly, we applied both Kazeem's and Lohmueller's methods for synthesizing family and case control studies and there was no statistically significant difference between the results from the two methods, suggesting that either method can be used. In addition, the association analysis of case-control studies was statistically consistent with that of family studies. Finally, the matrix of coancestry coefficient suggested obvious population stratification. The study reveals that one SNP of the NRG1 gene does not contribute significantly to schizophrenia and that population stratification is evident. In future genetic association analysis on complex psychic diseases, haplotype blocks and population structure should be given greater consideration.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Gong YG,Wu CN,Xing QH,Zhao XZ,Zhu J,He Ldoi
10.1016/j.schres.2009.03.017subject
Has Abstractpub_date
2009-06-01 00:00:00pages
109-14issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(09)00116-9journal_volume
111pub_type
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journal_title:Schizophrenia research
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更新日期:2012-04-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2017-12-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Schizophrenia research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.schres.2016.09.034
更新日期:2017-01-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(02)00527-3
更新日期:2003-04-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.06.012
更新日期:2013-08-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2006.02.025
更新日期:2006-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0920-9964(96)00065-5
更新日期:1996-11-15 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(98)00070-x
更新日期:1998-10-09 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(99)00006-7
更新日期:1999-08-17 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.schres.2010.09.015
更新日期:2011-02-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.07.016
更新日期:2015-10-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.01.012
更新日期:2015-03-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.03.027
更新日期:2013-06-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析
doi:10.1016/j.schres.2018.07.019
更新日期:2018-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(99)00098-5
更新日期:2000-03-16 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.09.018
更新日期:2015-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(98)00033-4
更新日期:1998-06-22 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.schres.2019.07.013
更新日期:2019-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0920-9964(88)90025-4
更新日期:1988-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2014.03.011
更新日期:2014-05-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2008.06.012
更新日期:2008-09-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2015.06.005
更新日期:2015-11-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2010.02.1071
更新日期:2010-06-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2006.07.025
更新日期:2006-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2017.04.025
更新日期:2018-02-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2014.07.045
更新日期:2014-10-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析
doi:10.1016/j.schres.2014.12.031
更新日期:2015-03-01 00:00:00
abstract::Heterozygous reeler mouse has been used as an animal model for schizophrenia based on several neuropathological and behavioral abnormalities homologous to schizophrenia. Since some of these abnormalities are primarily associated with altered BDNF signaling we investigated BDNF signaling in the frontal cortex of reeler...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2007.11.030
更新日期:2008-03-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.07.044
更新日期:2014-10-01 00:00:00