Abstract：
:The nucleus accumbens (NAcc) is often implicated in schizophrenia (SZ) pathology, but with little evidence to support its role. This study examined postmortem human tissue to determine if abnormalities are present in the dopaminergic or glutamatergic systems in the NAcc in SZ. We compared the protein levels of tyrosine hydroxylase (TH) and vesicular glutamate transporters vGLUT1 and vGLUT2 in control (n=7) and schizophrenia (n=13) subjects using Western blot analysis. The SZ subjects were further divided by treatment status: SZ on-drug (SZ-ON, n=6) and SZ off-drug (SZ-OFF, n=7), to assess the effects of antipsychotic treatment. TH protein levels were similar between control and SZ subjects, and there was no difference between SZ-ON and SZ-OFF subjects. Protein levels of vGLUT1 were similar in control and SZ subjects, and there was no difference in vGLUT1 protein levels between SZ-ON and SZ-OFF subjects. In contrast, vGLUT2 protein levels were significantly elevated in the SZ group (25% increase). Protein levels of vGLUT2 did not differ between SZ-ON and SZ-OFF subjects. Similar levels of TH suggest the presynaptic DA pathway may be normal in the NAcc in SZ. The elevated vGLUT2 protein levels, but not vGLUT1, suggest the NAcc receives increased glutamatergic input in SZ, possibly from thalamic or other subcortical origins. The similarity between SZ-ON and SZ-OFF subjects suggests that the results are not caused by APD treatment. These findings provide further insight into the role of the NAcc in SZ.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
McCollum LA,Roberts RCdoi
10.1016/j.schres.2015.08.041subject
Has Abstractpub_date
2015-12-01 00:00:00pages
369-373issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(15)00477-6journal_volume
169pub_type
杂志文章abstract：BACKGROUND:Functional remission (FR) is an intermediate and necessary step toward recovery, but is understudied in first-episode psychosis (FEP). We aimed to examine the rate and predictors of FR in FEP patients in the context of a randomized-controlled trial (RCT) comparing a 1-year extension of early intervention (Ex...
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更新日期：2016-05-01 00:00:00
abstract：:Second generation antipsychotics cause derangements in glucose metabolism that are often interpreted as insulin resistance. In previous studies we have shown that this is not classical insulin resistance but the drugs were actually inducing a hyperglycaemic state associated with elevated hepatic glucose output (HGO) a...
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更新日期：2014-08-01 00:00:00
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更新日期：2015-12-01 00:00:00
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更新日期：1999-07-27 00:00:00
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更新日期：2014-08-01 00:00:00
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更新日期：2016-11-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(96)00065-5
更新日期：1996-11-15 00:00:00
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更新日期：2019-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2011-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.schres.2016.04.032
更新日期：2016-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.schres.2009.09.014
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pub_type： 杂志文章
doi：10.1016/j.schres.2019.11.037
更新日期：2020-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.schres.2011.01.025
更新日期：2011-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.schres.2005.05.017
更新日期：2005-10-15 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.05.019
更新日期：2012-08-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.04.014
更新日期：2012-08-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/j.schres.2013.05.021
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更新日期：2017-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.schres.2012.05.014
更新日期：2012-08-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2008.06.002
更新日期：2008-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.schres.2020.01.021
更新日期：2020-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0920-9964(94)90051-5
更新日期：1994-10-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2013.10.014
更新日期：2013-12-01 00:00:00
abstract：:In 1990 a satellite session of the American College of Neuropsychopharmacology (ACNP) Annual Meeting was held that focused on the question of whether progressive changes in brain structure occur in schizophrenia and this session raised considerable controversy. Eighteen years later, on December 12, 2008, after much da...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.04.025
更新日期：2009-07-01 00:00:00
abstract：:Atypical antipsychotic drugs (AAPDs) are widely used in children and adolescents to treat a variety of psychiatric disorders. However, little is known about the long-term effects of AAPD treatment before the brain is fully developed. Indeed, we and others have previously reported that treatment of adolescent rats with...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.10.034
更新日期：2015-02-01 00:00:00
abstract：:Due to the limitations of analytical techniques and the complicity of schizophrenia, nowadays it is still a challenge to diagnose and stratify schizophrenia patients accurately. Many attempts have been made to identify and validate available biomarkers for schizophrenia from CSF and/or peripheral blood in clinical stu...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.03.009
更新日期：2020-12-01 00:00:00
