Reproducibility of fMRI activations during a story listening task in patients with schizophrenia.


:A prerequisite to longitudinal fMRI studies in schizophrenia is the knowledge on fMRI signal reliability in schizophrenia patients. We assessed the reproducibility of activations elicited by two fMRI sessions, which were 21 months apart, of a story listening paradigm in 10 schizophrenia patients and 10 healthy subjects. In both groups, we observed a high degree of spatial overlap of activation maps as well as a good reproducibility of signal variations assessed on a voxel-wise basis in temporal areas underlying early stages of language processing. Task performance, assessed through a comprehension questionnaire, had no impact on the activation reproducibility.


Schizophr Res


Schizophrenia research


Maïza O,Mazoyer B,Hervé PY,Razafimandimby A,Dollfus S,Tzourio-Mazoyer N




Has Abstract


2011-05-01 00:00:00














  • Schizophrenia risk factors constitute general risk factors for psychiatric symptoms in the population.

    abstract:BACKGROUND:The presence of a psychosis continuum is suggested by studies showing that schizophrenia and non-clinical psychotic symptoms in the general population share the same risk factors. However, to our knowledge no large-scale studies have been conducted which examine the specificity of these risk factors in the g...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Breetvelt EJ,Boks MP,Numans ME,Selten JP,Sommer IE,Grobbee DE,Kahn RS,Geerlings MI

    更新日期:2010-07-01 00:00:00

  • Comparative effects of glycine and D-cycloserine on persistent negative symptoms in schizophrenia: a retrospective analysis.

    abstract::Phencyclidine (PCP), ketamine and other N-methyl-D-aspartate (NMDA) antagonists induce schizophrenia-like symptoms in normal volunteers, suggesting that endogenous dysfunction or dysregulation of NMDA receptors may contribute to the pathophysiology of schizophrenia. Glycine and D-cycloserine are potential treatments f...

    journal_title:Schizophrenia research

    pub_type: 临床试验,杂志文章


    authors: Heresco-Levy U,Javitt DC

    更新日期:2004-02-01 00:00:00

  • Structural correlates of formal thought disorder in schizophrenia: An ultra-high field multivariate morphometry study.

    abstract:BACKGROUND:Persistent formal thought disorder (FTD) is one of the most characteristic features of schizophrenia. Several neuroimaging studies report spatially distinct neuroanatomical changes in association with FTD. Given that most studies so far have employed a univariate localisation approach that obscures the study...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Palaniyappan L,Mahmood J,Balain V,Mougin O,Gowland PA,Liddle PF

    更新日期:2015-10-01 00:00:00

  • Effect of retrieval effort and switching demand on fMRI activation during semantic word generation in schizophrenia.

    abstract::Verbal fluency deficits in schizophrenia are difficult to interpret because the tasks are multi-factorial and groups differ in total words generated. We manipulated retrieval and switching demands by requiring alternation between over-learned sequences in which retrieval is relatively automatic (OS) and semantic categ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Ragland JD,Moelter ST,Bhati MT,Valdez JN,Kohler CG,Siegel SJ,Gur RC,Gur RE

    更新日期:2008-02-01 00:00:00

  • Consistency of delusions in schizophrenia and affective disorder.

    abstract::The content of delusions were studied in a group of schizophrenics and affective disorder patients who had an episodic course to ascertain if the content of delusions remained similar or became dissimilar during different episodes. There were 18 schizophrenics and 30 affective disorder cases in this study. Consistency...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Sinha VK,Chaturvedi SK

    更新日期:1990-10-01 00:00:00

  • Temperament and executive dysfunctions in schizophrenia.

    abstract::Recent studies suggest that both executive dysfunction and personality traits combine with symptoms to affect the social outcome of persons with schizophrenia. This study was designed to investigate how personality traits influence executive function in schizophrenia. Forty-four patients with schizophrenia and twenty-...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Guillem F,Pampoulova T,Rinaldi M,Stip E

    更新日期:2008-09-01 00:00:00

  • Antipsychotic treatment patterns and hospitalizations among adults with schizophrenia.

    abstract:OBJECTIVE(S):To characterize the longitudinal patterns of antipsychotic treatment and to investigate the relationship between antipsychotic treatment patterns and acute hospitalizations among adults with schizophrenia. We hypothesized that continuous antipsychotic treatment would be associated with fewer hospitalizatio...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: dosReis S,Johnson E,Steinwachs D,Rohde C,Skinner EA,Fahey M,Lehman AF

    更新日期:2008-04-01 00:00:00

  • A case-control association study between the GRID1 gene and schizophrenia in the Chinese Northern Han population.

    abstract::The glutamatergic dysfunction hypothesis of schizophrenia implicates the genes involved in glutamatergic transmission as strong candidates for schizophrenia-susceptibility. Recent linkage and association studies have identified the glutamate receptor, ionotropic, delta 1 gene GRID1 on 10q22 as a strong candidate for s...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Guo SZ,Huang K,Shi YY,Tang W,Zhou J,Feng GY,Zhu SM,Liu HJ,Chen Y,Sun XD,He L

    更新日期:2007-07-01 00:00:00

  • Brain volumes as predictor of outcome in recent-onset schizophrenia: a multi-center MRI study.

    abstract::Gray matter brain volume decreases have been found in patients with schizophrenia as compared to healthy control subjects measured by using Magnetic Resonance Imaging (MRI). An association has been suggested between decreased gray matter volume and poor outcome in chronically ill patients with schizophrenia. The prese...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,多中心研究


    authors: van Haren NE,Cahn W,Hulshoff Pol HE,Schnack HG,Caspers E,Lemstra A,Sitskoorn MM,Wiersma D,van den Bosch RJ,Dingemans PM,Schene AH,Kahn RS

    更新日期:2003-11-01 00:00:00

  • A meta-analysis of emotion perception and functional outcomes in schizophrenia.

    abstract:INTRODUCTION:Emotion perception (EP) is impaired in schizophrenia, is stable across clinical state, resistant to antipsychotic treatment and linked to symptom severity. Given its pervasive nature, there is a need to quantitatively examine whether this dysfunction impacts functional outcomes. We used a meta-analytic str...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,meta分析


    authors: Irani F,Seligman S,Kamath V,Kohler C,Gur RC

    更新日期:2012-05-01 00:00:00

  • Neuropsychological status of subjects at high risk for a first episode of psychosis.

    abstract::Thirty-six subjects aged 16 years or older judged at risk for a first episode of psychosis within a North American multi-site study of the schizophrenia prodrome [McGlashan et al., Schizophr. Res. (2003); Miller et al., Schizophr. Res. (2003)] performed at levels intermediate to population norms and data reported for ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Hawkins KA,Addington J,Keefe RS,Christensen B,Perkins DO,Zipurksy R,Woods SW,Miller TJ,Marquez E,Breier A,McGlashan TH

    更新日期:2004-04-01 00:00:00

  • Cases of remission of psychosis following resection of pheochromocytoma or paraganglioma.

    abstract::The author previously proposed that schizophrenia has similar cytokine expression compared to melanoma, a neural crest cell tumor. One possible tumor model of schizophrenia includes anti-NMDA receptor encephalitis, a paraneoplastic syndrome. While examining the possible relationship of neural crest cell tumors to schi...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Brown JS Jr

    更新日期:2016-10-01 00:00:00

  • The Measure of Insight into Cognition: reliability and validity of clinician-rated and self-report scales of neurocognitive insight for schizophrenia.

    abstract::Poor insight into the neurocognitive deficits in schizophrenia-spectrum disorders may have significant clinical implications for treatment. The purpose of this study was to replicate and extend the psychometric findings initially reported on the Measure of Insight into Cognition Clinician-Rated (MIC-CR) and Self-Repor...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Saperstein AM,Thysen J,Medalia A

    更新日期:2012-01-01 00:00:00

  • Lexical knowledge degradation in schizophrenia.

    abstract::This study documents a severe picture naming impairment in a series of 22 chronically hospitalised schizophrenics. The pattern and level of naming impairment were comparable in degree and type to that seen neurological patients with left hemisphere lesions. This deficit was further examined to determine whether it con...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Laws KR,Al-Uzri M,Mortimer AM

    更新日期:2000-09-29 00:00:00

  • Corpus callosum and P300 in schizophrenia.

    abstract::Functional abnormalities in the interhemispheric transfer via the corpus callosum in schizophrenia may result in filtering problems and information processing problems, which may in turn be related to the synchronization of cortical event-related activity. To explore whether a relationship exists between corpus callos...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Frodl T,Meisenzahl EM,Müller D,Greiner J,Juckel G,Leinsinger G,Hahn H,Möller HJ,Hegerl U

    更新日期:2001-04-15 00:00:00

  • Weight gain with clozapine: 8-year cohort naturalistic study among hospitalized Chinese schizophrenia patients.

    abstract:OBJECTIVE:Clozapine is associated with significant weight gain. However, it is still debatable whether the majority of weight gain occurs in the early phase of treatment or if weight gain is a persistent side effect. The inconsistent results in previous outpatient studies may be due to many confounding factors, such as...

    journal_title:Schizophrenia research

    pub_type: 临床试验,杂志文章


    authors: Bai YM,Chen JY,Chen TT,Lin CY,Chou P,Su TP,Lin CC

    更新日期:2009-03-01 00:00:00

  • A comprehensive genetic association and functional study of TNF in schizophrenia risk.

    abstract::In view of prior reports suggesting associations between polymorphisms of the tumor necrosis factor gene (TNF) and schizophrenia, we sequenced all exons, introns and 7 kb flanking sequence at TNF in DNA pooled from 125 Caucasian schizophrenia cases and 200 controls. We identified 18 SNPs of which we selected and genot...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Shirts BH,Bamne M,Kim JJ,Talkowski M,Wood J,Yolken R,Nimgaonkar VL

    更新日期:2006-03-01 00:00:00

  • Metabolic abnormalities and low dietary Omega 3 are associated with symptom severity and worse functioning prior to the onset of psychosis: Findings from the North American Prodrome Longitudinal Studies Consortium.

    abstract:OBJECTIVE:Patients with schizophrenia have a high prevalence of metabolic disorders and cardiovascular mortality. It is possible that a vulnerability to metabolic abnormalities is associated with risk for psychosis, symptoms and functionality. In this study, we evaluate demographic information, cardiometabolic indices,...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,随机对照试验


    authors: Cadenhead KS,Minichino A,Kelsven S,Addington J,Bearden C,Cannon TD,Cornblatt BA,Mathalon D,McGlashan TH,Perkins DO,Seidman LJ,Tsuang M,Walker EF,Woods SW,Yao J,North American Prodromal Longitudinal Studies (NAPLS) consortiu

    更新日期:2019-02-01 00:00:00

  • Do we need oxytocin to treat schizophrenia? A randomized clinical trial.

    abstract:BACKGROUND:Schizophrenia is a disabling complex mental disorder and despite all available treatment, many patients unfortunately remain partial- or non-responders. A large body of research has shown that oxytocin is an important prosocial peptide and there is initial evidence that the central oxytocin system is altered...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,随机对照试验


    authors: Dagani J,Sisti D,Abelli M,Di Paolo L,Pini S,Raimondi S,Rocchi MB,Saviotti FM,Scocco P,Totaro S,Balestrieri M,de Girolamo G

    更新日期:2016-04-01 00:00:00

  • High-dose galantamine augmentation inferior to placebo on attention, inhibitory control and working memory performance in nonsmokers with schizophrenia.

    abstract::Dysfunction in the neuronal nicotinic acetylcholine receptor (nAChR) system has been implicated in the pathophysiology of schizophrenia, and it has been postulated that treatments that increase nAChR activity may improve symptoms of the disorder. We investigated the effects of the acetylcholinesterase inhibitor and al...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,随机对照试验


    authors: Dyer MA,Freudenreich O,Culhane MA,Pachas GN,Deckersbach T,Murphy E,Goff DC,Evins AE

    更新日期:2008-07-01 00:00:00

  • Negative symptoms in bipolar disorder and schizophrenia: A psychometric evaluation of the brief negative symptom scale across diagnostic categories.

    abstract::Past studies have demonstrated that the Brief Negative Symptom Scale (BNSS) has excellent psychometric properties in patients with schizophrenia. In the current study, we extended this literature by examining psychometric properties of the BNSS in outpatients diagnosed with bipolar disorder (n=46), outpatients with sc...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Strauss GP,Vertinski M,Vogel SJ,Ringdahl EN,Allen DN

    更新日期:2016-02-01 00:00:00

  • Psychotic disorder symptom rating scales: Are dichotomous or multi-point scales more clinically useful?-An ICD-11 field study.

    abstract::Classifications of psychotic disorders are moving towards utilizing dimensional symptom domains as the preferred mechanism for describing psychotic symptomatology. The ICD-11 has proposed six symptom domains (Positive symptoms, Negative symptoms, Depressive symptoms, Manic symptoms, Psychomotor symptoms, and Cognitive...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Keeley JW,Gaebel W,First MB,Peterson DL,Rebello T,Sharan P,Reed GM

    更新日期:2018-12-01 00:00:00

  • Prevalence of extrapyramidal syndromes in psychiatric inpatients and the relationship of clozapine treatment to tardive dyskinesia.

    abstract::In 200 inpatients on regular neuroleptics, point prevalence of extrapyramidal syndromes, including Parkinson syndrome, akathisia and tardive dyskinesia (TD), was studied and found to be 20, 11 and 22%, respectively. A total of 46 patients have currently, and for a longer time, (average about 3years, median over 1year)...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Modestin J,Stephan PL,Erni T,Umari T

    更新日期:2000-05-05 00:00:00

  • Depressive symptoms and presynaptic dopamine function in neuroleptic-naive schizophrenia.

    abstract::We have previously reported aberrations in the striatal presynaptic dopamine function in neuroleptic-naive schizophrenic patients compared to healthy controls (Hietala, J., Syvälahti, E., Vuorio, K. et al., 1995. Lancet 346, 1130-1131). In this extended study we explore whether the altered presynaptic dopamine functio...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Hietala J,Syvälahti E,Vilkman H,Vuorio K,Räkköläinen V,Bergman J,Haaparanta M,Solin O,Kuoppamäki M,Eronen E,Ruotsalainen U,Salokangas RK

    更新日期:1999-01-04 00:00:00

  • Hippocampal 5-hydroxytryptamine receptors: abnormalities in postmortem brain from schizophrenic subjects.

    abstract::There is strong evidence that hippocampal 5-hydroxytryptamine (5-HT) systems are affected in schizophrenia and hence we have studied a number of markers of the 5-HT system in hippocampi from subjects with schizophrenia. Using in situ radioligand binding with autoradiography we measured [(3)H]proplyamino-8-hydroxy-1,2,...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Scarr E,Pavey G,Copolov D,Dean B

    更新日期:2004-12-01 00:00:00

  • Interrater reliability of schizoaffective disorder compared with schizophrenia, bipolar disorder, and unipolar depression - A systematic review and meta-analysis.

    abstract::Schizoaffective disorder is a common diagnosis in clinical practice but its nosological status has been subject to debate ever since it was conceptualized. Although it is key that diagnostic reliability is sufficient, schizoaffective disorder has been reported to have low interrater reliability. Evidence based on syst...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,meta分析,评审


    authors: Santelmann H,Franklin J,Bußhoff J,Baethge C

    更新日期:2016-10-01 00:00:00

  • Is Wisconsin Card Sorting Test performance related to 'working memory' capacity?

    abstract::The Wisconsin Card Sorting Test (WCST) is a multifactorial and complex test, and it involves so many different kinds of functions that it is difficult to understand why patients fail. Capacity of 'working memory' is possibly involved in the WCST performance and is considered a relevant factor responsible for the schiz...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Stratta P,Daneluzzo E,Prosperini P,Bustini M,Mattei P,Rossi A

    更新日期:1997-10-17 00:00:00

  • Recovery style and outcome in first-episode psychosis.

    abstract::Our study aimed to investigate how recovery styles influence 12-month clinical outcome in first-episode psychosis patients. We hypothesised that patients who use an integrative recovery style would have better outcome than those who seal over. A total of 196 first-episode psychosis patients from the Early Psychosis In...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Thompson KN,McGorry PD,Harrigan SM

    更新日期:2003-07-01 00:00:00

  • A population-based cohort study on deep vein thrombosis and pulmonary embolism among schizophrenia patients.

    abstract:OBJECTIVE:Several risk factors of venous thromboembolism (VTE) and pulmonary embolism (PE) were found in patients with schizophrenia. Therefore, we hypothesize that the incidences of VTE and PE are relatively higher among schizophrenia patients in comparison with the general population. METHOD:For this population-base...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Hsu WY,Lane HY,Lin CL,Kao CH

    更新日期:2015-03-01 00:00:00

  • Verbal and visual memory: characterizing the clinical and intermediate phenotype in schizophrenia.

    abstract:BACKGROUND:Verbal and visual memory deficits are prominent trait markers for schizophrenia, with impairments also observed in first-degree relatives [Snitz, B.E., Macdonald, A.W., 3rd, & Carter, C.S. (2006). Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: a meta-analytic review of put...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Skelley SL,Goldberg TE,Egan MF,Weinberger DR,Gold JM

    更新日期:2008-10-01 00:00:00