Reproducibility of fMRI activations during a story listening task in patients with schizophrenia.


:A prerequisite to longitudinal fMRI studies in schizophrenia is the knowledge on fMRI signal reliability in schizophrenia patients. We assessed the reproducibility of activations elicited by two fMRI sessions, which were 21 months apart, of a story listening paradigm in 10 schizophrenia patients and 10 healthy subjects. In both groups, we observed a high degree of spatial overlap of activation maps as well as a good reproducibility of signal variations assessed on a voxel-wise basis in temporal areas underlying early stages of language processing. Task performance, assessed through a comprehension questionnaire, had no impact on the activation reproducibility.


Schizophr Res


Schizophrenia research


Maïza O,Mazoyer B,Hervé PY,Razafimandimby A,Dollfus S,Tzourio-Mazoyer N




Has Abstract


2011-05-01 00:00:00














  • Prefrontal cortical sulcal widening associated with poor treatment response to clozapine.

    abstract::Increased sulcal widening in the prefrontal cortex of patients with schizophrenia may be associated with a poor treatment response to clozapine. To further evaluate this, we examined data from patients treated with clozapine in our center. Patients with the greatest degree of improvement (n=26) and those with no impro...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Konicki PE,Kwon KY,Steele V,White J,Fuller M,Jurjus GJ,Jaskiw GE

    更新日期:2001-03-30 00:00:00

  • Lexical knowledge degradation in schizophrenia.

    abstract::This study documents a severe picture naming impairment in a series of 22 chronically hospitalised schizophrenics. The pattern and level of naming impairment were comparable in degree and type to that seen neurological patients with left hemisphere lesions. This deficit was further examined to determine whether it con...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Laws KR,Al-Uzri M,Mortimer AM

    更新日期:2000-09-29 00:00:00

  • Lowered paraoxonase 1 (PON1) activity is associated with increased cytokine levels in drug naïve first episode psychosis.

    abstract:BACKGROUND:Activated immune-inflammatory pathways play an important role in the pathophysiology of schizophrenia. Paraoxonase 1 (PON1) activity is inversely associated with inflammatory responses in numerous clinical conditions. The aims of this study were to delineate serum arylesterase PON1 activity in drug-naïve fir...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Brinholi FF,Noto C,Maes M,Bonifácio KL,Brietzke E,Ota VK,Gadelha A,Cordeiro Q,Belangero SI,Bressan RA,Vargas HO,Higachi L,de Farias CC,Moreira EG,Barbosa DS

    更新日期:2015-08-01 00:00:00

  • Patterns of premorbid functioning in individuals at clinical high risk of psychosis.

    abstract::In schizophrenia, four typical patterns of premorbid functioning have been observed: stable-good, stable-intermediate, poor-deteriorating and deteriorating. However, it is unknown whether similar patterns exist in those who are at clinical high risk (CHR) of psychosis. The aim of this study was to examine patterns of ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Lyngberg K,Buchy L,Liu L,Perkins D,Woods S,Addington J

    更新日期:2015-12-01 00:00:00

  • Red blood cell membrane dynamics in schizophrenia. I. Membrane fluidity.

    abstract::Using the fluorescent probe DPH (1,6-diphenyl-1,3,5-hexatriene), steady-state anisotropy (rs) values were determined in red blood cell (RBC) ghost membranes of schizophrenic patients before (n = 26) and after (n = 16) haloperidol withdrawal, and age- and sex-matched normal controls (n = 22). Patients on haloperidol we...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Yao JK,van Kammen DP

    更新日期:1994-02-01 00:00:00

  • Abstract and experiential thinking differentially account for anomalous perception of reality in people with or without schizophrenia.

    abstract::repetitive thinking is often increased in various psychopathological conditions. However, evidence for its possible contribution to psychotic symptoms relies only on correlational analysis and has not been experimentally tested within the psychotic continuum. This research aims to examine whether repetitive thinking a...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Ricarte JJ,Del Rey F,Ros L,Latorre JM,Berna F

    更新日期:2018-03-01 00:00:00

  • The neurobiology of relapse in schizophrenia.

    abstract::Dopamine's proposed role in psychosis proved a starting point in our understanding of the neurobiology of relapse, fitting given the central role positive symptoms play. This link is reflected in early work examining neurotransmitter metabolite and drug (e.g. amphetamine, methylphenidate) challenge studies as a means ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,评审


    authors: Remington G,Foussias G,Agid O,Fervaha G,Takeuchi H,Hahn M

    更新日期:2014-02-01 00:00:00

  • Reprint of: Internalising symptoms mediate the longitudinal association between childhood inflammation and psychotic-like experiences in adulthood.

    abstract::Psychotic-like experiences (PLEs) are part of a continuum of psychosis. Previous longitudinal studies highlighted a relationship between peripheral inflammation during childhood and onset of PLEs in adulthood. In this study, we tested if this association is mediated by internalising and externalising symptoms experien...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Francesconi M,Minichino A,Khandaker GM,Midouhas E,Lewis G,Flouri E

    更新日期:2020-12-01 00:00:00

  • Time-based but not event-based prospective memory remains impaired one year after the onset of schizophrenia: A prospective study.

    abstract:BACKGROUND:Prospective memory (PM) deficits have been consistently found in people with schizophrenia. Although there is evidence to suggest that PM deficits may be putative markers for schizophrenia, no longitudinal study has investigated the persistence of PM deficits. AIMS:We examined whether PM deficits persist af...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Cheung EFC,Lui SSY,Wang Y,Yang TX,Shum DHK,Chan RCK

    更新日期:2015-12-01 00:00:00

  • Schizophrenia spectrum disorders, substance misuse, and the four-facet model of psychopathy: the relationship to violence.

    abstract:OBJECTIVE:To investigate the relationship between the four-facet model of PCL-R psychopathy and violence in a community-based sample of Australian men with schizophrenia-spectrum disorders. METHOD:A community sample of 94 males with schizophrenia-spectrum disorders was recruited from mental health services within Vict...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: McGregor K,Castle D,Dolan M

    更新日期:2012-04-01 00:00:00

  • Treatment of rats with antipsychotic drugs: lack of an effect on brain N-acetyl aspartate levels.

    abstract:BACKGROUND:Proton magnetic resonance spectroscopy (1H-MRS) studies of schizophrenia suggest an effect of the disease or of antipsychotic medications on brain N-acetyl aspartate (NAA), a marker of neuronal viability. We studied in the rat the effect of antipsychotic drugs on NAA in several brain regions where NAA reduct...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Bustillo J,Wolff C,Myers-y-Gutierrez A,Dettmer TS,Cooper TB,Allan A,Lauriello J,Valenzuela CF

    更新日期:2004-01-01 00:00:00

  • The Audio-Visual Abnormalities Questionnaire (AVAQ): Development and validation of a new instrument for assessing anomalies in sensory perception in schizophrenia spectrum disorders.

    abstract:BACKGROUND:Anomalies in visual and auditory perception represent an important aspect of the symptomatic manifestation of schizophrenia (ScZ). However, there are currently no instruments available that allow the assessment of the full range of auditory and visual abnormalities using a self-report measure. METHODS:We de...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Nikitova N,Keane BP,Demmin D,Silverstein SM,Uhlhaas PJ

    更新日期:2019-07-01 00:00:00

  • NPY mRNA expression in the prefrontal cortex: Selective reduction in the superficial white matter of subjects with schizoaffective disorder.

    abstract:BACKGROUND:Alterations in the inhibitory circuitry of the dorsolateral prefrontal cortex (DLPFC) in schizophrenia include reduced expression of the messenger RNA (mRNA) for somatostatin (SST), a neuropeptide present in a subpopulation of gamma-aminobutyric acid (GABA) neurons. Neuropeptide Y (NPY) is expressed in a sub...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Morris HM,Stopczynski RE,Lewis DA

    更新日期:2009-12-01 00:00:00

  • Negative symptoms in bipolar disorder and schizophrenia: A psychometric evaluation of the brief negative symptom scale across diagnostic categories.

    abstract::Past studies have demonstrated that the Brief Negative Symptom Scale (BNSS) has excellent psychometric properties in patients with schizophrenia. In the current study, we extended this literature by examining psychometric properties of the BNSS in outpatients diagnosed with bipolar disorder (n=46), outpatients with sc...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Strauss GP,Vertinski M,Vogel SJ,Ringdahl EN,Allen DN

    更新日期:2016-02-01 00:00:00

  • Hippocampal and orbital inferior frontal gray matter volume abnormalities and cognitive deficit in treatment-naive, first-episode patients with schizophrenia.

    abstract:BACKGROUND:Cognitive impairment is a core feature of schizophrenia. Some evidence suggests an association between cognition deficits and gray matter reductions. In this study, we investigated the relationship between cognitive performance and gray matter volumes in patients with treatment-naïve, first-episode schizophr...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Guo X,Li J,Wang J,Fan X,Hu M,Shen Y,Chen H,Zhao J

    更新日期:2014-02-01 00:00:00

  • Psychotic experiences in childhood are associated with increased structural integrity of the left arcuate fasciculus - A population-based case-control study.

    abstract::Around 1 in 5 children under 13 years old experience sub-clinical psychotic experiences (PEs) like hallucinations and delusions. While PEs in childhood are a significant risk factor for adult psychotic disorders, the majority of those experiencing childhood PEs do not develop a psychotic disorder. Individual differenc...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Dooley N,O'Hanlon E,Healy C,Adair A,McCandless C,Coppinger D,Kelleher I,Clarke M,Leemans A,Frodl T,Cannon M

    更新日期:2020-01-01 00:00:00

  • Cognitive and brain function in schizotypal personality disorder.

    abstract::Schizotypal personality disorder, a diagnosis defined partially in terms of a genetic relatedness to schizophrenia, has begun to receive extensive investigative study. While the exact etiologic relationship between schizotypal personality disorder and schizophrenia remains to be determined, three models have been cons...

    journal_title:Schizophrenia research



    authors: Siever LJ,Koenigsberg HW,Harvey P,Mitropoulou V,Laruelle M,Abi-Dargham A,Goodman M,Buchsbaum M

    更新日期:2002-03-01 00:00:00

  • Effects of clozapine, fluphenazine, and placebo on reaction time measures of attention and sensory dominance in schizophrenia.

    abstract::Two reaction time (RT) paradigms were used to study clozapine's effects on sustained and selective attention compared to fluphenazine and placebo in 25 chronic schizophrenic patients. Sensory dominance was studied via simple and choice RTs to lights and tones, and on double-stimulus trials in which the two stimuli wer...

    journal_title:Schizophrenia research

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Zahn TP,Pickar D,Haier RJ

    更新日期:1994-09-01 00:00:00

  • Pre-morbid fertility in psychosis: findings from the AESOP first episode study.

    abstract::Individuals with psychotic illnesses are known to have a reduced fertility. It is unclear whether this is due to biological or social factors. Most fertility studies have been conducted in chronic schizophrenia, where confounders like medication and hospitalisation make this difficult to elicit. A less severe reductio...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Zimbron J,Stahl D,Hutchinson G,Dazzan P,Morgan K,Doody GA,Jones PB,Murray RM,Fearon P,Morgan C,MacCabe JH

    更新日期:2014-07-01 00:00:00

  • The effect of zonisamide on antipsychotic-associated weight gain in patients with schizophrenia: a randomized, double-blind, placebo-controlled clinical trial.

    abstract:BACKGROUND:Many patients with schizophrenia suffer from metabolic symptoms and weight gain in which predispose them to obesity, diabetes, and cardiovascular problems. This trial examines the efficacy and safety of zonisamide on weight and body mass index in patients with schizophrenia being administered with atypical a...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,随机对照试验


    authors: Ghanizadeh A,Nikseresht MS,Sahraian A

    更新日期:2013-06-01 00:00:00

  • Wakefulness and arousal in neonates born to women with schizophrenia: diminished arousal and its association with neurological deviations.

    abstract::Arousal at 3-4 days of age was blindly assessed during the course of a standardized neurological examination of offspring born to index women with schizophrenic (n = 20), schizo-affective (n = 12), affective (n = 19) and unspecified functional (n = 4) psychoses, as well as 70 offspring born to control women with no hi...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Schubert EW,Blennow G,McNeil TF

    更新日期:1996-10-18 00:00:00

  • Repetitive transcranial magnetic stimulation for negative symptoms of schizophrenia: a randomized controlled pilot study.

    abstract:BACKGROUND:Negative symptoms in schizophrenia are associated with deficits in executive function and frequently prove highly resistant to neuroleptic medication. Using repetitive transcranial magnetic stimulation (rTMS) to activate the prefrontal cortex has been suggested as a treatment for negative symptoms. METHODS:...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,随机对照试验


    authors: Mogg A,Purvis R,Eranti S,Contell F,Taylor JP,Nicholson T,Brown RG,McLoughlin DM

    更新日期:2007-07-01 00:00:00

  • Independence and overlap among neurocognitive correlates of community functioning in schizophrenia.

    abstract::Existing literature on the neurocognitive correlates of community functioning in schizophrenia has not adequately focused on the relationships among the correlated variables. In a sample of 40 outpatients with schizophrenia and related disorders, we studied two sets of variables that we expected to be related to broad...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Dickinson D,Coursey RD

    更新日期:2002-07-01 00:00:00

  • Goal-directed planning and action impairments in schizophrenia evaluated in a virtual environment.

    abstract::Planning and executing goal-directed behaviours are critical final steps in translating motivation into action. Amotivation is a key feature of schizophrenia, but its impact on goal-directed functioning has not been extensively studied in an objective and ecologically valid manner. To address this, we investigated goa...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Siddiqui I,Saperia S,Fervaha G,Da Silva S,Jeffay E,Zakzanis KK,Agid O,Remington G,Foussias G

    更新日期:2019-04-01 00:00:00

  • Psychological well-being and mental health recovery in the NIMH RAISE early treatment program.

    abstract::Recovery-oriented practices that promote client-centered care, collaboration, and functional outcome have been recommended to improve treatment engagement, especially for individuals with serious mental illness (SMI). Psychological well-being (PWB) is related to recovery and refers to experiencing purpose and meaning ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Browne J,Penn DL,Meyer-Kalos PS,Mueser KT,Estroff SE,Brunette MF,Correll CU,Robinson J,Rosenheck RA,Schooler N,Robinson DG,Addington J,Marcy P,Kane JM

    更新日期:2017-07-01 00:00:00

  • Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population.

    abstract::It has been reported that expression of the chromogranin A (CHGA) gene is reduced in the prefrontal cortex and cerebrospinal fluid of patients with schizophrenia. Single-marker and haplotype analyses of SNPs within the CHGA gene were performed in 633 subjects with schizophrenia and 589 healthy controls. A significant ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Takahashi N,Ishihara R,Saito S,Maemo N,Aoyama N,Ji X,Miura H,Ikeda M,Iwata N,Suzuki T,Kitajima T,Yamanouchi Y,Kinoshita Y,Ozaki N,Inada T

    更新日期:2006-04-01 00:00:00

  • The Experience of Caregiving Inventory for first-episode psychosis caregivers: validation of the Brazilian version.

    abstract::Family members of first-episode psychosis (FEP) patients are regarded as key components of the patient's evaluation, recovery and treatment. This paper aimed to investigate 75 FEP caregivers' appraisal, psychological morbidity and quality of life in the initial phase of treatment in a specialized FEP outpatient progra...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Jorge Rde C,Chaves AC

    更新日期:2012-07-01 00:00:00

  • Brain volumes as predictor of outcome in recent-onset schizophrenia: a multi-center MRI study.

    abstract::Gray matter brain volume decreases have been found in patients with schizophrenia as compared to healthy control subjects measured by using Magnetic Resonance Imaging (MRI). An association has been suggested between decreased gray matter volume and poor outcome in chronically ill patients with schizophrenia. The prese...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,多中心研究


    authors: van Haren NE,Cahn W,Hulshoff Pol HE,Schnack HG,Caspers E,Lemstra A,Sitskoorn MM,Wiersma D,van den Bosch RJ,Dingemans PM,Schene AH,Kahn RS

    更新日期:2003-11-01 00:00:00

  • Impaired emotional learning and reduced amygdala size in schizophrenia: a 3-month follow-up.

    abstract::Individuals with schizophrenia have difficulties in emotional information processing. A relationship between behavioral variables of emotional processing and structural amygdala alterations in schizophrenia has been proposed but not shown, yet. Morphological studies of amygdala size in schizophrenia have yielded incon...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Exner C,Boucsein K,Degner D,Irle E,Weniger G

    更新日期:2004-12-01 00:00:00

  • Who needs antipsychotic medication in the earliest stages of psychosis? A reconsideration of benefits, risks, neurobiology and ethics in the era of early intervention.

    abstract::In recent years, early intervention services have attempted to identify people with a first episode of psychosis as early as possible, reducing the duration of untreated psychosis and changing the timing of delivery of interventions. The logic of early intervention is based partly on accessing people in a more treatme...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,评审


    authors: Francey SM,Nelson B,Thompson A,Parker AG,Kerr M,Macneil C,Fraser R,Hughes F,Crisp K,Harrigan S,Wood SJ,Berk M,McGorry PD

    更新日期:2010-06-01 00:00:00