Abstract：
:Dopamine (DA) D2 receptors which act by modulating second messenger pathways that include protein kinase C (PKC) and adenylate cyclase (AC) have been repeatedly shown to be increased in striatum from subjects with schizophrenia. Therefore it seemed possible that chronic up-regulation of DA-D2 receptors in the schizophrenic brain could result in a change in either of these two proteins. Hence we measured PKC and AC in striatum from 20 schizophrenic subjects and 20 non-schizophrenic subjects by quantitative autoradiography and could show no difference in the density of either PKC (436 +/- 35 vs. 485 +/- 29 fmol/mg tissue equivalents (TE), mean +/- SEM) or AC (77 +/- 9 vs. 80 +/- 7 fmol/mg TE) in the tissue from schizophrenic compared to the non-schizophrenic subjects. Thus, these data do not support the hypothesis that PKC or AC are changed in the schizophrenic brain.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Opeskin K,Dean B,Pavey G,Hill C,Keks N,Copolov Ddoi
10.1016/s0920-9964(96)00065-5subject
Has Abstractpub_date
1996-11-15 00:00:00pages
159-64issue
2eissn
0920-9964issn
1573-2509pii
S0920-9964(96)00065-5journal_volume
22pub_type
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