Behavioral sequelae of astrocyte dysfunction: focus on animal models of schizophrenia.

Abstract:

:Astrocytes regulate multiple processes in the brain ranging from trophic support of developing neurons to modulation of synaptic neurotransmission and neuroinflammation in adulthood. It is, therefore, understandable that pathogenesis and pathophysiology of major psychiatric disorders involve astrocyte dysfunctions. Until recently, there has been the paucity of experimental approaches to studying the roles of astrocytes in behavioral disease. A new generation of in vivo models allows us to advance our understanding of the roles of astrocytes in psychiatric disorders. This review will evaluate the recent studies that focus on the contribution of astrocyte dysfunction to behavioral alterations pertinent to schizophrenia and will propose the possible solutions of the limitations of the existing approaches.

journal_name

Schizophr Res

journal_title

Schizophrenia research

authors

Xia M,Abazyan S,Jouroukhin Y,Pletnikov M

doi

10.1016/j.schres.2014.10.044

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

72-82

issue

1

eissn

0920-9964

issn

1573-2509

pii

S0920-9964(14)00639-2

journal_volume

176

pub_type

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