Abstract:
UNLABELLED:Subjective quality of life (S-QoL) is an important outcome measure in first episode psychosis (FEP). The aims of this study were to describe S-QoL-development the first 10-years in FEP patients and to identify predictors of this development. METHODS:A representative sample of 272 patients with a first episode psychotic disorder was included from 1997 through 2000. At 10 year follow-up 186 patients participated. QoL was measured by the Lehman's Quality of Life Interview. Linear mixed model analyses were performed to investigate longitudinal effects of baseline psychiatric symptoms and socio-economic variables and the effects of changes in the same variables on S-QoL-development. RESULTS:S-QoL improved significantly over the follow-up period. More contact with family and a better financial situation at baseline had a positive and longstanding effect on S-QoL-development, but changes in these variables were not associated with S-QoL-development. Higher depressive symptoms and less daily activities at baseline both had a negative independent effect, but a positive interaction effect with time on S-QoL-development indicating that the independent negative effect diminished over time. In the change analysis, increased daily activities and a decrease in depressive symptoms were associated with a positive S-QoL-development. CONCLUSIONS:Treatment of depressive symptoms and measures aimed at increasing daily activities seem important to improve S-QoL in patients with psychosis. More contact with family and a better financial situation at baseline have a long-standing effect on S-QoL-development in FEP patients.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Gardsjord ES,Romm KL,Friis S,Barder HE,Evensen J,Haahr U,ten Velden Hegelstad W,Joa I,Johannessen JO,Langeveld J,Larsen TK,Opjordsmoen S,Rund BR,Simonsen E,Vaglum P,McGlashan T,Melle I,Røssberg JIdoi
10.1016/j.schres.2016.02.034subject
Has Abstractpub_date
2016-04-01 00:00:00pages
23-8issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(16)30087-1journal_volume
172pub_type
杂志文章abstract::The aim of this study is to compare the neurocognitive functions in individuals with clinical or genetic risk for psychosis, in patients with first-episode schizophrenia (FES) and in healthy controls. We compared cognitive functions of 52 individuals at ultra high risk (UHR) for psychosis, 53 patients with FES, their ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.10.030
更新日期:2013-12-01 00:00:00
abstract::Younger patients with schizophrenia have most likely experienced fewer adverse consequences of the illness than older patients who may have experienced a lifetime of treatment as well as socio-economic problems as a consequence of the illness. There is limited information regarding differential efficacy of long-acting...
journal_title:Schizophrenia research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.schres.2016.09.034
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:Childhood abuse and neglect are risk factors for psychotic symptoms. Early adversities may contribute to alterations in neuro/social cognition, which in turn is associated with psychosis. This study explored the possible mediating/moderating role of neuro/social cognition between childhood abuse and neglec...
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abstract::The guarantee of perceptual coherence for events through everyday life situations depends upon the capacity to correctly integrate series of multi-sensory experiences. Patients with schizophrenia have been shown to reveal a deficit in integrating, i.e., "binding", perceptual information together. However, results in t...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2007.08.013
更新日期:2007-12-01 00:00:00
abstract::Schizophrenia and at-risk populations are suggested to exhibit referential cohesion deficits in language production (e.g., producing fewer pronouns or nouns that clearly link to concepts from previous sentences). Much of this work has focused on transcribed speech samples, while no work to our knowledge has examined r...
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journal_title:Schizophrenia research
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abstract:INTRODUCTION:Dysfunctional serotonin signaling has been linked to the pathogenesis of autism, obsessive compulsive disorder, mood disorders and schizophrenia. While the hypo-activity of serotonin signaling is involved in the pathogenesis of depression, anxiety and obsessive compulsive disorder; LSD, an agonist of serot...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.12.007
更新日期:2014-02-01 00:00:00
abstract::Patients with schizophrenia exhibit impairments in prepulse inhibition (PPI) of the startle response. Available data suggest that atypical antipsychotics may be more effective than typical antipsychotics in improving PPI deficits in schizophrenia. However, previous studies have used between-subjects rather than longit...
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journal_title:Schizophrenia research
pub_type: 传,历史文章,杂志文章
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更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:Quality of life (QOL) is considered an important outcome in the treatment of schizophrenia, but the determinants of QOL are poorly understood in this population. Furthermore, previous studies have relied on combined measures of subjective QOL (usually defined as life satisfaction) and objective QOL (usually d...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2007.09.001
更新日期:2008-01-01 00:00:00
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更新日期:2020-01-01 00:00:00
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doi:10.1016/j.schres.2014.10.032
更新日期:2014-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2018.09.007
更新日期:2019-02-01 00:00:00
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doi:10.1016/j.schres.2013.07.052
更新日期:2013-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2008.01.014
更新日期:2008-07-01 00:00:00
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doi:10.1016/j.schres.2009.08.011
更新日期:2010-02-01 00:00:00
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doi:10.1016/j.schres.2011.11.019
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2007.09.022
更新日期:2007-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.03.012
更新日期:2010-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0920-9964(02)00295-5
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abstract::CACNA1C (12p13.3) has been implicated as a susceptibility gene for schizophrenia by several replicated genome wide association studies. While these results have been consistent among studies in European populations, the findings in East Asian populations have varied. To test whether CACNA1C is a risk gene for schizoph...
journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析
doi:10.1016/j.schres.2013.12.003
更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2009.05.031
更新日期:2009-09-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2012-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2016.11.032
更新日期:2017-07-01 00:00:00