Abstract:
:While the "clinical high-risk state" for psychosis has demonstrated good reliability and fair predictive validity for psychotic disorders, over 50% of identified subjects do not progress to psychosis. Despite the benefits that early detection and treatment might offer, debate concerning the official inclusion of a "psychosis risk syndrome" in the upcoming DSM-V frequently involves concerns about the impact of stigma on patients, families and institutions. We add to this debate by providing an analysis of the theoretical and empirical stigma literature to evaluate the potential effects of stigma associated with the psychosis risk syndrome. Theorists' conceptualizations of how stigma exerts its negative effects emphasize internalization of pejorative societal stereotypes ('self-stigma'), negative emotional reactions, harmful behavioral coping strategies, and structural discrimination as key mechanisms. Studies assessing the comparative effects of symptomatic behavior when compared with a psychiatric diagnosis label in predicting rejecting social attitudes indicate that treating symptomatic behaviors is likely to diminish overall stigma. However, any publically held 'preexisting conceptions' about what a psychosis risk syndrome means are still likely to exert negative effects. Additionally, particular features of this syndrome--that it occurs during adolescence when identity formation may be in flux--may also shape manifestations of stigma. Utilizing other well-established 'at-risk' conditions (e.g., genetic susceptibility) to model potential discrimination for this syndrome, we suggest that future discrimination is likely to occur in insurance and family domains. We conclude by proposing stigma measurement strategies, including recommending that field trials prior to DSM-V adopt systematic measures to assess any stigma that this psychosis risk syndrome might confer via future community use.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Yang LH,Wonpat-Borja AJ,Opler MG,Corcoran CMdoi
10.1016/j.schres.2010.03.012subject
Has Abstractpub_date
2010-07-01 00:00:00pages
42-8issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(10)01182-5journal_volume
120pub_type
杂志文章abstract:OBJECTIVES:In the present study, we used Activation Likelihood Estimation (ALE) meta-analysis to quantitatively examine brain grey matter reduction in schizophrenia patients with persistent negative symptoms (PNS). METHOD:A total of 12 voxel-based morphometry (VBM) studies were included in ALE meta-analysis using more...
journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.schres.2017.04.005
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:The InterSePT Scale for Suicidal Thinking (ISST) is a 12-item instrument for the assessment of current suicidal ideation in patients with schizophrenia and schizoaffective disorders. We report the psychometric characteristics of this new scale based on two studies. METHOD:In Study 1, 22 inpatients with schi...
journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/s0920-9964(02)00335-3
更新日期:2003-09-01 00:00:00
abstract::Comorbid substance abuse disorders have emerged as one of the greatest obstacles to the effective treatment of persons with schizophrenia. Estimates of the prevalence of such comorbidity vary, but as many as half of persons with schizophrenia may suffer from a comorbid drug or alcohol disorder. Younger age, male gende...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/s0920-9964(98)00161-3
更新日期:1999-03-01 00:00:00
abstract::The functional integrity of the dorsolateral prefrontal cortex (DLPFC) is altered in schizophrenia leading to profound deficits in working memory and cognition. Growing evidence indicates that dysregulation of glutamate signaling may be a significant contributor to the pathophysiology mediating these effects; however,...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2007.09.022
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:There is increased interest in the impact of new long-acting treatments on health-related quality of life (HRQoL) in patients with schizophrenia. The aim of this study was to evaluate the impact of treatment with subcutaneous injections of RBP-7000, a new sustained-release formulation of risperidone, compare...
journal_title:Schizophrenia research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.schres.2016.03.020
更新日期:2016-07-01 00:00:00
abstract::Schizophrenia is associated with subtle developmental compromise, but the degree to which this is also associated with heritability and genetic risk is uncertain. The goal of the current study was to investigate the childhood, adolescent, and early adulthood social and academic function of patients with schizophrenia,...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.04.007
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:Tumor necrosis factor alpha (TNFalpha), a cytokine involved in inflammatory processes, has been implicated in the pathophysiology of schizophrenia. The chromosomal location in the major histocompatibility complex (MHC) region on 6p21.1-21.3, a region with evidence for linkage, suggests a role in susceptibili...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(02)00534-0
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVE:This study aims to differentiate schizoaffective disorder (SAD) and bipolar-I-disorder (BD) in first-episode psychotic mania (FEPM). METHODS:All 134 patients from an epidemiological first-episode psychosis cohort (N=786) with FEPM and an 18-month follow-up final diagnosis of SAD (n=36) or BD (n=98) were asse...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2012.07.010
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Higher liability to psychosis is associated with low self-esteem and increased sensitivity to social stress. Recently, we reported a positive relation between liability to psychosis and affective and psychotic responses to social stress. This study investigated how self-esteem moderates paranoia, peak subjec...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2018.06.042
更新日期:2018-12-01 00:00:00
abstract::Dysfunction in the neuronal nicotinic acetylcholine receptor (nAChR) system has been implicated in the pathophysiology of schizophrenia, and it has been postulated that treatments that increase nAChR activity may improve symptoms of the disorder. We investigated the effects of the acetylcholinesterase inhibitor and al...
journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2007.12.491
更新日期:2008-07-01 00:00:00
abstract::Vulnerability-stress models suggest that training in specific stress management techniques should yield benefits to those suffering from schizophrenia and related disorders. In this paper, we describe an evaluation of the impact of adding a stress management program to other medical and psychosocial interventions for ...
journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0920-9964(01)00371-1
更新日期:2002-12-01 00:00:00
abstract::Schizotypal personality disorder, a diagnosis defined partially in terms of a genetic relatedness to schizophrenia, has begun to receive extensive investigative study. While the exact etiologic relationship between schizotypal personality disorder and schizophrenia remains to be determined, three models have been cons...
journal_title:Schizophrenia research
pub_type:
doi:10.1016/s0920-9964(01)00363-2
更新日期:2002-03-01 00:00:00
abstract::Recent studies of cerebral pathology in patients with schizophrenia have focused on symptomatological and electrophysiological correlates of reduced temporal lobe structure volumes. Volume deficits of the left superior temporal gyrus have been correlated with auditory hallucinations as well as to left-sided P300 ampli...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(99)00006-7
更新日期:1999-08-17 00:00:00
abstract:BACKGROUND:Verbal and visual memory deficits are prominent trait markers for schizophrenia, with impairments also observed in first-degree relatives [Snitz, B.E., Macdonald, A.W., 3rd, & Carter, C.S. (2006). Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: a meta-analytic review of put...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2008.05.027
更新日期:2008-10-01 00:00:00
abstract::There is some evidence that memory for temporal order is a process that may be impaired independently of other forms of memory. For example, patients with Korsakoff's syndrome have been shown to have poorer temporal-order memory than other amnesic patients, despite item memory being equivalent. Patients with schizophr...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(00)00014-1
更新日期:2000-12-15 00:00:00
abstract::Evidence suggests that insight in psychosis has been related to treatment adherence, recovery and good prognosis, but also to depression, low self-esteem, and diminished quality of life. Thus, insight might not be advantageous under all circumstances. Internalized-stigma (i.e. self-acceptance of stigmatizing images of...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.03.010
更新日期:2015-05-01 00:00:00
abstract::Second generation antipsychotics cause derangements in glucose metabolism that are often interpreted as insulin resistance. In previous studies we have shown that this is not classical insulin resistance but the drugs were actually inducing a hyperglycaemic state associated with elevated hepatic glucose output (HGO) a...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.05.003
更新日期:2014-08-01 00:00:00
abstract::The role of mentalizing abilities (or theory of mind) and empathic abilities in violent behavior were studied in 24 hospitalized males with paranoid schizophrenia (ICD-10). Patients were divided into violent and nonviolent groups based on their history of committing violent acts against others. To examine these abilit...
journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章
doi:10.1016/S0920-9964(03)00049-5
更新日期:2004-07-01 00:00:00
abstract::Recent research on risk for psychosis has focused on youth who manifest subclinical signs that are often associated with the prodrome to psychosis. Standardized measures of prodromal symptoms have been shown to significantly enhance prediction of risk for conversion to an Axis I psychotic disorder. In the present stud...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2011.03.034
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVES:White matter (WM) abnormalities are one of the most widely and consistently reported findings in schizophrenia (SZ) and bipolar disorder (BD). If these abnormalities are inherited determinants of illness, suitable to be classified as an endophenotype, relatives of patients must also have them at higher rate ...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2014.12.008
更新日期:2015-02-01 00:00:00
abstract::Treatment resistant schizophrenia (TRS) is defined by poor or non-response to conventional antipsychotic agents. Functional capacity is defined as the baseline potential of a patient to function in the community, irrespective of actual achievements gained, and has never been studied in TRS. Here, we screened 182 patie...
journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章
doi:10.1016/j.schres.2018.06.030
更新日期:2018-12-01 00:00:00
abstract::MicroRNAs (miRNAs) are small non-coding RNAs that mainly function as negative regulators of gene expression (Lai, 2002) and have been shown to be involved in schizophrenia etiology through genetic and expression studies (Burmistrova et al., 2007; Hansen et al., 2007a; Perkins et al., 2007; Beveridge et al., 2010; Kim ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2012.06.038
更新日期:2012-10-01 00:00:00
abstract:INTRODUCTION:Contextual factors representing chronic stressors, such as neighborhood crime characteristics, have been repeatedly linked to compromised mental and physical health, and may contribute to the pathologizing of normative/non-clinical experiences. However, the impact of such structural factors has seldom been...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2019.11.024
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Psychotic-like experiences (PLEs) during adolescence are not uncommon and potentially represent a clinical and public health concern. A greater understanding of their aetiology and patterns of change over time is needed. We aimed to describe trajectories of PLEs during adolescence, and examine their associat...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2012.06.024
更新日期:2012-09-01 00:00:00
abstract::Diffusion tensor imaging (DTI) studies suggest abnormalities in the white matter microstructure of the fornix in schizophrenia patients. Research evaluating schizophrenia patient and relatives also suggests that the white matter microstructure of the fornix is heritable. However, previous studies have been hindered by...
journal_title:Schizophrenia research
pub_type: 历史文章,杂志文章
doi:10.1016/j.schres.2014.09.037
更新日期:2014-11-01 00:00:00
abstract::Evidence validating the influence of the cytochrome P450 (CYP) 2D6 and 2C19 enzymes genetic polymorphisms in the response to antipsychotics is scarce. We examined the hypothesis that a higher prevalence of CYP2D6 and/or CYP2C19 ultra rapid metabolizers might be found among refractory schizophrenia patients. Three grou...
journal_title:Schizophrenia research
pub_type: 信件
doi:10.1016/j.schres.2015.08.002
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Negative symptoms are a core feature of schizophrenia. The evolution and trajectory of primary negative symptoms were under-studied. We aimed at evaluating the prevalence and stability of primary negative symptoms, and factors associated with persistent primary negative symptoms in a first-episode sample. M...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2011.09.006
更新日期:2011-12-01 00:00:00
abstract::Neurological Examination Abnormalities (NEA) are prevalent in schizophrenia, but the significance of this is obscured by methodological problems. The Neurological Evaluation Scale (NES), the most widely used structured neurological examination in schizophrenia research, has had limited study of its inter-rater reliabi...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(97)00103-5
更新日期:1998-02-09 00:00:00
abstract::The dot pattern expectancy (DPX) task has been strongly recommended as a measure of goal maintenance, which is impaired in schizophrenia patients. The current event-related potential (ERP) study was designed mainly to identify the ERP component that could represent the goal maintenance process of the DPX task as index...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2017.09.038
更新日期:2018-05-01 00:00:00
abstract::Attention Deficit/Hyperactivity Disorder (ADHD) is the most common psychiatric disorder in childhood. It is unclear whether ADHD increases the risk of non-affective psychotic disorder (NAPD). The study included a matched cohort, drawn from all born in Sweden 1987-1991 (n = 548,852). ADHD was defined as ICD diagnosis a...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2020.01.021
更新日期:2020-04-01 00:00:00