Abstract：
:Individuals diagnosed with schizophrenia spectrum disorders have significant neuropsychological deficits that have been linked to poor functional outcome. As more treatments are developed and implemented for cognitive impairments, it will be important to consider whether people with schizophrenia have insight into the neuropsychological symptoms of their illness. Just as insight into psychotic symptoms plays a significant role in treatment compliance, it is likely that insight into neuro-cognitive dysfunction will be associated with compliance with cognitive remediation or cognitive enhancing medications. The objective of this study was to evaluate self reported awareness of cognitive deficit in schizophrenia using the MIC-SR, a new scale, and to compare self report of cognitive deficit with actual neuropsychological performance, and with the MIC-SR performance of Healthy Controls. Patients with schizophrenia reported significantly more cognitive problems as occurring "Almost Daily" than did Healthy Controls. However, Patients were most likely to respond that a cognitive problem "Never" occurred, whereas Healthy Controls most often responded "Once a Week or Less". The Total Score on the MIC-SR did not prove useful in differentiating Healthy Controls from Patients. About one quarter of the cognitively impaired patients with schizophrenia showed no awareness of cognitive deficit on the MIC-SR. This suggests that clinicians must use self report judiciously as an indicator of actual cognitive impairment. The MIC-SR captures a range of awareness of cognitive difficulty. The data indicates that there are many patients who would benefit from psycho-education about the impact of schizophrenia on neuro-cognition.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Medalia A,Thysen J,Freilich Bdoi
10.1016/j.schres.2008.07.007subject
Has Abstractpub_date
2008-10-01 00:00:00pages
156-64issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(08)00324-1journal_volume
105pub_type
杂志文章abstract：:Motivational deficits in patients with schizophrenia adversely affect various domains of daily living. This symptom in everyday life situations manifests in a complex behavioral pattern whose root cannot be simplified to an impaired reward-motivation scheme. This study aimed to identify impairment of the salience netw...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.01.019
更新日期：2018-07-01 00:00:00
abstract：OBJECTIVE:This study aims to differentiate schizoaffective disorder (SAD) and bipolar-I-disorder (BD) in first-episode psychotic mania (FEPM). METHODS:All 134 patients from an epidemiological first-episode psychosis cohort (N=786) with FEPM and an 18-month follow-up final diagnosis of SAD (n=36) or BD (n=98) were asse...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.07.010
更新日期：2012-09-01 00:00:00
abstract：:Past studies have demonstrated that the Brief Negative Symptom Scale (BNSS) has excellent psychometric properties in patients with schizophrenia. In the current study, we extended this literature by examining psychometric properties of the BNSS in outpatients diagnosed with bipolar disorder (n=46), outpatients with sc...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.12.014
更新日期：2016-02-01 00:00:00
abstract：INTRODUCTION:This study investigates the effect of exposure to "The Troubles" (the period of civil unrest from 1968 onwards) in Northern Ireland on symptomatology in people with schizophrenia. METHOD:Eighty-two participants were assessed on a number of psychiatric rating scales and on measures of trauma, including an ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2008.02.012
更新日期：2008-07-01 00:00:00
abstract：BACKGROUND:Bullying victimisation has been suggested to contribute to paranoid ideation in general population samples and recent evidence found that individuals with an ultra high risk (UHR) for psychosis are twice as likely to have been bullied than controls. AIMS:This study sought to examine whether a history of bul...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.08.029
更新日期：2015-10-01 00:00:00
abstract：:Schizophrenia is associated with significant impairments in both higher and lower order social cognitive performance and these impairments contribute to poor social functioning. People with schizophrenia report poor social functioning to be one of their greatest unmet treatment needs. Recent studies have suggested the...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2015.06.005
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND:Formal thought disorder (FTD) is a core feature of psychosis, however there are gaps in our knowledge about its prevalence and factor structure. We had two aims: first, to establish the factor structure of FTD; second, to explore the clinical utility of dimensions of FTD in order to further the understanding...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.07.049
更新日期：2015-10-01 00:00:00
abstract：:Mental illness stigma may contribute to suicidality and is associated with social isolation and low self-esteem among young people at risk of psychosis. However, it is unclear whether mental illness stigma contributes to suicidality in this population. We therefore examined the associations of self-labeling and stigma...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.01.048
更新日期：2016-04-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.05.002
更新日期：2014-08-01 00:00:00
abstract：:Microtubule associated proteins (MAPs) are central to the development of normal neuronal cytoarchitecture and have been reported to be altered in schizophrenia. In 12 schizophrenic (DSM-III-R criteria) and 12 control hippocampi, we estimated the MAP2 immunoreactive dendritic length using antibodies that recognize tota...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(99)00068-7
更新日期：2000-01-21 00:00:00
abstract：:Deficits in learning and memory are among the most robust correlates of schizophrenia. It has been hypothesized that these deficits are in part due to reduced conscious recollection and increased reliance on familiarity assessment as a basis for retrieval. The Remember-Know (R-K) paradigm was administered to 35 patien...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.09.021
更新日期：2008-03-01 00:00:00
abstract：BACKGROUND:Aprosody, or flattened speech intonation, is a recognized negative symptom of schizophrenia, though it has rarely been studied from a linguistic/phonological perspective. To bring the latest advances in computational linguistics to the phenomenology of schizophrenia and related psychotic disorders, a clinica...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.10.005
更新日期：2012-12-01 00:00:00
abstract：OBJECTIVE:Recent years have witnessed growing interest in the role of the social environment in the development and outcomes of schizophrenia. We investigated whether neighborhood characteristics are associated with two important prognostic factors in early-course psychosis, age at onset of psychosis (AOP) and duration...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.12.036
更新日期：2020-04-01 00:00:00
abstract：:We previously reported a schizophrenia associated reduction of neuronal and oligodendrocyte number in the anterior principal thalamic nucleus (APN) in a cohort of severely impaired elderly subjects with schizophrenia (SZ) relative to age matched nonpsychiatric controls (NCs). The present study was undertaken to determ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2008.08.023
更新日期：2008-12-01 00:00:00
abstract：BACKGROUND:The extent of heterogeneity in the long-term course of schizophrenia is unclear. AIMS:To examine the course of schizophrenia in a population-based cohort. METHODS:This study included all Israeli individuals born in 1970-1988, of North African or European origin (N=2290), entered in the National Psychiatric...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2010.10.026
更新日期：2011-03-01 00:00:00
abstract：:Persistent cannabis use among young adults with first episode psychosis (FEP), even those receiving early intervention services, has been associated with poor outcomes. In the United States (US), Coordinated Specialty Care (CSC) has been shown to be more effective at reducing symptoms, improving quality of life and in...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2020.05.035
更新日期：2020-08-01 00:00:00
abstract：:In this study we use high resolution Magnetic Resonance imaging (MRI) and apply rigorous manual tracing criteria in order to assess volumetrically the prefrontal cortex (PFC) in schizophrenia. Previous MRI studies suggested PFC is included in neural systems necessary for emotional processing and cognition, and regiona...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.10.026
更新日期：2014-01-01 00:00:00
abstract：:Characterizing a pattern of cognitive dysfunction in early onset schizophrenic patients may illuminate neurodevelopmental contributions to the illness. A cohort of chronically institutionalized schizophrenic patients with a variable range of age of onset (range 7-29 years) was administered a comprehensive battery of n...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(95)00065-8
更新日期：1996-05-01 00:00:00
abstract：BACKGROUND:The number of antipsychotic prescriptions dispensed annually in England has increased substantially over the past decade. It is not known whether this is due to changes in prescribing practices, or an increase in the prevalence of psychosis. To our knowledge, no previous studies have investigated temporal tr...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2020.11.057
更新日期：2021-01-09 00:00:00
abstract：:The positive and negative syndrome scale (PANSS) is widely used in psychiatric research. Reflecting this common use, considerable attention has been applied to the psychometric properties of this instrument. However, despite the publication of numerous studies and analyses, it remains uncertain how best data from the ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(02)00295-5
更新日期：2003-05-01 00:00:00
abstract：:Recovery-oriented practices that promote client-centered care, collaboration, and functional outcome have been recommended to improve treatment engagement, especially for individuals with serious mental illness (SMI). Psychological well-being (PWB) is related to recovery and refers to experiencing purpose and meaning ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.11.032
更新日期：2017-07-01 00:00:00
abstract：:The involvement of the gamma-aminobutyric acid (GABA) system in schizophrenia is suggested by postmortem studies and the common use of GABA receptor-potentiating agents in treatment. In a recent study, we used a benzodiazepine challenge to demonstrate abnormal GABAergic function during processing of negative visual st...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.08.022
更新日期：2015-10-01 00:00:00
abstract：:In order to investigate a possible relationship between schizophrenic births and viral diseases, the birth month and year of all state hospital admissions for schizophrenia in Connecticut and Massachusetts from 1973-1974 were compared with the occurrence of reportable viral diseases for 1920-1955. Data was statistical...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(88)90043-6
更新日期：1988-01-01 00:00:00
abstract：:Persons with schizophrenia experience deficits in social cognition-the cognitive processes involved in how people perceive and interpret information about themselves, others, and social situations. These deficits may be related to the neurocognitive impairments often experienced by persons with schizophrenia. Our prim...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(01)00405-4
更新日期：2003-02-01 00:00:00
abstract：BACKGROUND:D-serine is an allosteric modulator of the brain N-methyl-d-aspartate (NMDA) receptor and a potential novel treatment of schizophrenia. Double-blind studies have been performed at 30 mg/kg/day (approximately 2 g/day) with encouraging results, but no formal dose escalation studies have been performed. We desc...
journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章
doi：10.1016/j.schres.2010.05.012
更新日期：2010-08-01 00:00:00
abstract：:Left or mixed-handedness, footedness, and eye dominance are thought to indicate abnormalities in lateralization related to schizophrenia. Increased left or mixed-dominance in schizophrenia suggests possible hemispheric abnormalities associated with the disorder. A related body of research suggests that some indication...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2004.04.003
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:Cannabis and cocaine are the most common illicit drugs for which people are treated in addiction services in Latin America. Much research has suggested that the use of cannabis increases the risk of schizophrenia; there is less evidence concerning cocaine. The aim of the present study was to establish the re...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.04.010
更新日期：2018-04-01 00:00:00
abstract：:A review of 65 studies of individuals with schizophrenia who had never been treated with antipsychotic medications indicates significant abnormalities in brain structure and function. Neurological and neuropsychological measures show the most consistent and largest group differences between those affected and normal c...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/s0920-9964(02)00381-x
更新日期：2002-12-01 00:00:00
abstract：:Younger patients with schizophrenia have most likely experienced fewer adverse consequences of the illness than older patients who may have experienced a lifetime of treatment as well as socio-economic problems as a consequence of the illness. There is limited information regarding differential efficacy of long-acting...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.schres.2016.09.034
更新日期：2017-01-01 00:00:00
abstract：:The ubiquitin ligase F-box protein 45 (FBXO45) is critical for synaptogenesis, neuronal migration, and synaptic transmission. FBXO45 is included in the 3q29 microdeletion region that confers a significant risk for schizophrenia, as shown by rare structural variant studies. Thus, FBXO45 is considered a prominent candid...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.04.032
更新日期：2014-08-01 00:00:00
