Abstract:
:CACNA1C (12p13.3) has been implicated as a susceptibility gene for schizophrenia by several replicated genome wide association studies. While these results have been consistent among studies in European populations, the findings in East Asian populations have varied. To test whether CACNA1C is a risk gene for schizophrenia, we conducted a case-control study in 5897 schizophrenic patients and 6323 healthy control subjects selected from Han Chinese population. Our study replicated the positive associations of rs1006737 (P=0.0108, OR=1.16, 95% CI: 1.03-1.29) and rs1024582 (P=0.0062, OR=1.18, 95% CI: 1.05-1.33), and identified a novel risk locus, rs2007044 (P=0.0053, OR=1.08, 95% CI: 1.02-1.14). A meta-analysis of rs1006737 combining our study and previous studies was conducted in a total of 8222 schizophrenia cases and 24,661 healthy controls. In the meta-analysis, the association between rs1006737 and schizophrenia remained significant (OR=1.14, 95% CI: 1.07-1.22, P=0.0001). Stratified analysis showed no heterogeneity between East Asian and European ancestries (χ(2)[1]=0.07, P=0.795), and the difference in pooled ORs between ancestries was not significant (Z=0.25, P=0.801). Our results provide further support for associations of rs1006737 and rs1024582 with schizophrenia, identify a new risk locus rs2007044 in a Han Chinese population, and further establish CACNA1C as an important susceptibility gene for the disease across world populations.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Zheng F,Zhang Y,Xie W,Li W,Jin C,Mi W,Wang F,Ma W,Ma C,Yang Y,Du B,Li K,Liu C,Wang L,Lu T,Zhang H,Wang Y,Lu L,Lv L,Zhang D,Yue Wdoi
10.1016/j.schres.2013.12.003subject
Has Abstractpub_date
2014-01-01 00:00:00pages
105-10issue
1eissn
0920-9964issn
1573-2509pii
S0920-9964(13)00656-7journal_volume
152pub_type
杂志文章,meta分析abstract::The aim of this study was to test the validity of the CHR state by focusing on the course of psychosis spectrum symptoms, depression and global functioning in converters and non-converters. A total of 188 CHR-positive subjects (60.2% men) aged between 13 and 35years (mean=20.5) at study outset were assessed five times...
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pub_type: 杂志文章
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doi:10.1016/j.schres.2015.09.015
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journal_title:Schizophrenia research
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doi:10.1016/j.schres.2010.03.041
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doi:10.1016/s0920-9964(01)00405-4
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pub_type: 杂志文章
doi:10.1016/j.schres.2018.07.006
更新日期:2018-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/s0920-9964(02)00294-3
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2011.07.021
更新日期:2011-11-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2008.03.012
更新日期:2008-07-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.08.041
更新日期:2015-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2011.09.016
更新日期:2011-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2012.12.033
更新日期:2013-04-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2007-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2012.08.020
更新日期:2012-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(01)00378-4
更新日期:2002-11-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.07.003
更新日期:2011-03-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章
doi:10.1016/j.schres.2017.03.040
更新日期:2017-12-01 00:00:00
abstract::Patients with schizophrenia did not take significantly more trials than normal controls to learn to use a visual warning signal to avoid a non-aversive stimulus on a simple computer-administered avoidance learning task. When the stimulus to be avoided was aversive (i.e., a loud buzzer), however, the schizophrenic grou...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(98)00181-9
更新日期:1999-07-27 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.07.021
更新日期:2009-10-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
doi:10.1016/j.schres.2006.02.010
更新日期:2006-05-01 00:00:00