Abstract：
:Executive functioning (EF) impairments are common in schizophrenia. There are two propositions regarding the causes of these impairments: (1) executive impairments are the result of the compounding effects of deficits in lower order cognitive skills (e.g. processing speed, attention) or (2) EF impairments exist in their own right regardless of lower order skills. It is difficult to examine the separable effects of lower order cognitive skills on EF given the overlap required to complete most neuropsychological measures. One battery designed to parcel out the contributions of lower order skills from EF is the Delis-Kaplan Executive Function System (D-KEFS). Inhibition and switching specifically were examined using the D-KEFS versions of the Stroop and Trails task. No group differences in task performance after controlling for lower level skills would provide evidence for a generalised cognitive deficit. Group differences remaining after controlling for these influences would suggest a disproportionate deficit. Results supported both propositions. On both tasks, group differences reflecting slowed reaction time in the schizophrenia group disappeared when lower order skills were controlled for. Differences between groups performance in errors were only evident on the most complex versions of each task with more errors made by the schizophrenia group. These results suggest that (1) both RT and error data are needed to provide a full picture of performance and (2) the relationship between lower order and EF is too complex to provide support for one or the other proposal.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Neill E,Rossell SLdoi
10.1016/j.schres.2013.07.034subject
Has Abstractpub_date
2013-10-01 00:00:00pages
76-80issue
1eissn
0920-9964issn
1573-2509pii
S0920-9964(13)00378-2journal_volume
150pub_type
杂志文章abstract：:Persons with schizophrenia experience deficits in social cognition-the cognitive processes involved in how people perceive and interpret information about themselves, others, and social situations. These deficits may be related to the neurocognitive impairments often experienced by persons with schizophrenia. Our prim...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(01)00405-4
更新日期：2003-02-01 00:00:00
abstract：:The presence of delusions is considered a key feature of psychosis, but despite the psychopathological centrality of the concept of delusion, its definition and comprehension is a matter of continuing debate. In recent years studies showing that delusions are common in the general population have accumulated and chall...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2019.10.043
更新日期：2020-02-01 00:00:00
abstract：:Polydipsia and water intoxication (PWI) are relatively frequent among schizophrenic subjects, particularly in institutional settings and may lead to severe complications. However, little is known on their association with other characteristics of psychosis. Hence, we took advantage of a cohort of 114 subjects extensiv...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.12.036
更新日期：2010-05-01 00:00:00
abstract：:CACNA1C gene polymorphism rs2007044 has been reported to be associated with schizophrenia, but its underlying brain mechanism is not clear. First, we conducted an exploratory functional magnetic resonance imaging (fMRI) study using an N-BACK task and a Stroop task in 194 subjects (55 schizophrenia patients and 139 hea...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.09.007
更新日期：2019-02-01 00:00:00
abstract：:Prior studies of mRNA expression, protein expression, and pathway metabolite levels have implicated dysregulation of the kynurenine pathway in the etiology of schizophrenia and bipolar disorder. Here we investigate whether genes involved in kynurenine pathway regulation might interact with genes that respond to kynure...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.05.014
更新日期：2009-09-01 00:00:00
abstract：:Schizophrenia is a severe psychiatric disorder with lifetime prevalence of ~1% worldwide. A genotyping study was conducted using a custom panel of Illumina 1536 SNPs in 840 schizophrenia cases and 876 controls (351 patients and 385 controls from North India; and 436 patients, 401 controls and 143 familial samples with...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析
doi：10.1016/j.schres.2014.12.031
更新日期：2015-03-01 00:00:00
abstract：:The incidence of cancer was studied in a cohort of all first admitted 9156 patients in Denmark with a diagnosis of schizophrenia in the period 1970-1987. The overall incidence of cancer was reduced particularly in the males. Adjustment for the smoking habits of psychiatric patients enhanced this risk reduction. Fewer ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(94)90028-0
更新日期：1994-06-01 00:00:00
abstract：OBJECTIVE:To examine the effect of diagnosis, mood state, and anxiety on subjective wellbeing in patients with affective and non-affective psychotic disorders treated with quetiapine IR. METHODS:2175 patients with schizophrenia-spectrum (SZ, n=1681), schizoaffective (SA, n=249), and bipolar disorder (BPD, n=245) were ...
journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章
doi：10.1016/j.schres.2009.03.004
更新日期：2009-05-01 00:00:00
abstract：:The aim of this study is to compare the neurocognitive functions in individuals with clinical or genetic risk for psychosis, in patients with first-episode schizophrenia (FES) and in healthy controls. We compared cognitive functions of 52 individuals at ultra high risk (UHR) for psychosis, 53 patients with FES, their ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.10.030
更新日期：2013-12-01 00:00:00
abstract：:Recent research on risk for psychosis has focused on youth who manifest subclinical signs that are often associated with the prodrome to psychosis. Standardized measures of prodromal symptoms have been shown to significantly enhance prediction of risk for conversion to an Axis I psychotic disorder. In the present stud...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2011.03.034
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND:Cannabis use may decrease age at onset in both schizophrenia and bipolar disorder, given the evidence for substantial phenotypic and genetic overlap between both disorders. METHODS:766 patients, aged 16 to 65 years, were assessed with the Composite International Diagnostic Interview (CIDI) for substance abu...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2010.07.003
更新日期：2011-03-01 00:00:00
abstract：:Cannabis use is highly prevalent worldwide and it is associated with psychosis, but its effects on brain structure and cognition are still controversial. The aim of this paper is to investigate cognitive functioning and brain structure in patients with their first episode of psychosis who used Cannabis. We examined gr...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.04.009
更新日期：2013-07-01 00:00:00
abstract：:Deficits in N-methyl-d-aspartate-type (NMDAR) function contribute to cognitive deficits in schizophrenia, particularly dysfunction in neuroplasticity, defined as reduced learning during training on exercises that place implicit, increasing demands on early sensory (auditory and visual) information processing. Auditory...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2018.02.003
更新日期：2019-05-01 00:00:00
abstract：:Interleukin-1 beta, interleukin-6, tumor necrosis factor-alpha and the soluble interleukin-2 receptor were measured in the serum of 34 healthy controls and 48 patients with chronic schizophrenia using ELISA sandwich assays. No differences were found between the controls and patients. ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(95)00089-5
更新日期：1996-05-01 00:00:00
abstract：:Attention Deficit/Hyperactivity Disorder (ADHD) is the most common psychiatric disorder in childhood. It is unclear whether ADHD increases the risk of non-affective psychotic disorder (NAPD). The study included a matched cohort, drawn from all born in Sweden 1987-1991 (n = 548,852). ADHD was defined as ICD diagnosis a...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2020.01.021
更新日期：2020-04-01 00:00:00
abstract：:Normally, when two brief, non-startling auditory stimuli are presented 500 ms apart, with long (e.g., 10 s) interpair intervals, the positive potential occurring approx. 50 ms after the first stimulus (P50) is relatively large, and the P50 to the second stimulus is smaller. In schizophrenia patients, however, the P50 ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(97)00122-9
更新日期：1998-02-27 00:00:00
abstract：BACKGROUND:Many social processes such as emotion recognition are severely impaired in patients with schizophrenia. While basic auditory processing seems to play a key role in identifying emotions, research in this field is limited due to the lack of proper assessment batteries. Many of the widely accepted tests utilize...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.11.043
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:Severity of negative symptoms has been associated with poor functioning, cognitive deficits, and defeatist beliefs in schizophrenia patients. However, one area that remains understudied is persistent negative symptoms (PNS). Negative symptoms, including PNS, have been observed in those at clinical high-risk ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2020.04.004
更新日期：2020-04-30 00:00:00
abstract：:Evidence validating the influence of the cytochrome P450 (CYP) 2D6 and 2C19 enzymes genetic polymorphisms in the response to antipsychotics is scarce. We examined the hypothesis that a higher prevalence of CYP2D6 and/or CYP2C19 ultra rapid metabolizers might be found among refractory schizophrenia patients. Three grou...
journal_title：Schizophrenia research
pub_type： 信件
doi：10.1016/j.schres.2015.08.002
更新日期：2015-10-01 00:00:00
abstract：:Though negative symptoms in schizophrenia are associated with a host of deleterious outcomes (e.g., White et al., 2009), not all individuals with schizophrenia suffer from negative symptoms (e.g., Blanchard et al., 2005). Thus, methods to quickly screen and identify patients for more intensive clinical interview asses...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2011.12.007
更新日期：2012-03-01 00:00:00
abstract：:Previous studies have indicated that schizophrenic patients have olfactory deficits. The question as to whether olfactory deficits are due to chronic effects of medication has not been addressed. This is the first paper to report that never-medicated schizophrenic patients also have olfactory deficits. Twenty four nor...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(93)90008-7
更新日期：1993-03-01 00:00:00
abstract：:Omega-3 treatment studies for multi-episode schizophrenia or clinical high risk for conversion to psychosis states have had variable, and often negative, results. To examine adjunctive omega-3 treatment for recent onset psychosis, participants aged 15-40 years with recent onset schizophrenia-spectrum (n = 46) or bipol...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2018.09.006
更新日期：2019-02-01 00:00:00
abstract：:Schizophrenia is characterized by increased mortality for which suicidality is the decisive factor. An analysis of cortical thickness and folding to further elucidate neuroanatomical correlates of suicidality in schizophrenia has not yet been performed. We searched for relevant brain regions with such differences betw...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.08.010
更新日期：2016-10-01 00:00:00
abstract：:Recent meta-analytic evidence suggests that clinical neuropsychological methods are not likely to uncover circumscribed cognitive impairments in the deficit syndrome of schizophrenia. To overcome this issue, we adapted a cognitive neuroscience perspective and used a new "chaining" habit learning task. Participants wer...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.06.027
更新日期：2008-02-01 00:00:00
abstract：:Studying Klinefelter syndrome (47,XXY), a genetically defined disorder characterized by the presence of an additional X chromosome, can reveal insights into genotype-phenotype associations. Increased vulnerability to psychiatric disorders characterized by difficulties in social interactions, such as schizophrenia and ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2006.02.020
更新日期：2006-06-01 00:00:00
abstract：OBJECTIVES:White matter (WM) abnormalities are one of the most widely and consistently reported findings in schizophrenia (SZ) and bipolar disorder (BD). If these abnormalities are inherited determinants of illness, suitable to be classified as an endophenotype, relatives of patients must also have them at higher rate ...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2014.12.008
更新日期：2015-02-01 00:00:00
abstract：:Aim Research regarding the effect of antipsychotic medications on the risk of upper respiratory infection (URI) progression to pneumonia in patients with schizophrenia is rare. This study investigated the effect of antipsychotic use on the risk of URI progression to pneumonia in patients with schizophrenia. METHODS:T...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2020.05.013
更新日期：2020-08-01 00:00:00
abstract：:Arinami et al. (1994) reported an association between the Ser311/Cys311 variant of the DRD2 gene and schizophrenia in a Japanese population. We did not find statistically significant differences in the distribution of the allele frequencies between schizophrenics (103) and controls (97) in a case-control sample (chi 2...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/S0920-9964(97)00013-3
更新日期：1997-05-24 00:00:00
abstract：BACKGROUND:Aberrations in body perception are common in psychotic disorders. The insula and temporoparietal junction (TPJ) are involved in body ownership and spatial perception suggesting that abnormal structure of these regions might be related to the expression of perceptual aberrations in psychosis. METHODS:58 indi...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.10.005
更新日期：2017-01-01 00:00:00
abstract：:Individuals with schizophrenia have very high rates of cigarette smoking, and much has been discovered about the influence of nicotine on brain functioning in schizophrenia. However, less is understood about the relationship between nicotine consumption and milder phenotypes related to schizophrenia, specifically schi...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.08.024
更新日期：2007-12-01 00:00:00
