Abstract：
:Cannabis use is highly prevalent worldwide and it is associated with psychosis, but its effects on brain structure and cognition are still controversial. The aim of this paper is to investigate cognitive functioning and brain structure in patients with their first episode of psychosis who used Cannabis. We examined gray matter and lateral ventricle volumes in 28 patients with first-episode psychosis and a history of Cannabis use, 78 patients without a history of Cannabis use and 80 healthy controls who had not used Cannabis. Cognition was assessed using forward and backwards digit span tests, from the Wechsler Memory Scale-Third Edition (WMS-III) and the Controlled Oral Word Association Test (COWAT). Patients with a history of Cannabis use had less brain abnormalities, characterized by gray matter and lateral ventricle volume preservation, as well as less attentional and executive impairments compared to patients without a history of Cannabis use. Cannabis-using patients who develop psychosis have less neurodevelopmental impairment and better cognitive reserve than other psychotic patients; perhaps reflecting different etiological processes.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Cunha PJ,Rosa PG,Ayres Ade M,Duran FL,Santos LC,Scazufca M,Menezes PR,dos Santos B,Murray RM,Crippa JA,Busatto GF,Schaufelberger MSdoi
10.1016/j.schres.2013.04.009subject
Has Abstractpub_date
2013-07-01 00:00:00pages
209-15issue
2-3eissn
0920-9964issn
1573-2509pii
S0920-9964(13)00209-0journal_volume
147pub_type
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