Abstract：
:The presence of delusions is considered a key feature of psychosis, but despite the psychopathological centrality of the concept of delusion, its definition and comprehension is a matter of continuing debate. In recent years studies showing that delusions are common in the general population have accumulated and challenged the way we perceive psychotic illness. In this systematic review, we examine the basis of the psychosis continuum-hypothesis, by reviewing a representative section of the original literature that report measures of delusional ideation in the general population, focusing specifically on methodology. Three online databases were systematically searched for relevant studies. After applying criteria of inclusion and exclusion, 17 articles were included for comprehensive review. Estimates of the distribution of delusions in the general population vary substantially, as does the mode of assessment. The methodology relies with few exceptions exclusively on self-report and fully structured interview by lay person. We conclude that measures of delusions in the general population should be interpreted cautiously due to inherent difficulties in methodology. Hypothesizing a continuum of delusion between normality and full-blown psychosis is deemed premature based on the reviewed studies.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Heilskov SER,Urfer-Parnas A,Nordgaard Jdoi
10.1016/j.schres.2019.10.043subject
Has Abstractpub_date
2020-02-01 00:00:00pages
48-55eissn
0920-9964issn
1573-2509pii
S0920-9964(19)30478-5journal_volume
216pub_type
杂志文章,评审abstract：OBJECTIVE:We examined the relationship between cerebral gray matter (GM) volume and severity of delusions and hallucinations in adults with schizophrenia. METHOD:MRI scans in 43 patients with schizophrenia were acquired. Correlations were computed between GM volume and clinician ratings of hallucinations and delusions...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2011.08.004
更新日期：2011-12-01 00:00:00
abstract：:Biomarkers which predict response to atypical antipsychotic drugs (AAPDs) increases their benefit/risk ratio. We sought to identify common variants in genes which predict response to lurasidone, an AAPD, by associating genome-wide association study (GWAS) data and changes (Δ) in Positive And Negative Syndrome Scale (P...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.schres.2017.04.009
更新日期：2018-02-01 00:00:00
abstract：:Previous studies have indicated that schizophrenic patients have olfactory deficits. The question as to whether olfactory deficits are due to chronic effects of medication has not been addressed. This is the first paper to report that never-medicated schizophrenic patients also have olfactory deficits. Twenty four nor...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(93)90008-7
更新日期：1993-03-01 00:00:00
abstract：:Theory of mind (ToM) is the ability to understand mental states of others and it is crucial for building sensitivity to other persons or events. Measuring ToM is important for understanding and rehabilitating social cognitive impairments in persons with schizophrenia. The Social Attribution Task-Multiple Choice (SAT-M...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.06.022
更新日期：2018-11-01 00:00:00
abstract：:Various theories have been proposed to account for poor insight in schizophrenia. This study examined the relationships between insight, mood, schizophrenic symptoms and cognitive functioning. The relationship between longitudinal changes in insight and changes in symptoms and mood was also investigated. One-hundred p...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(98)00142-x
更新日期：1999-02-15 00:00:00
abstract：BACKGROUND:To develop a pharmacokinetic-pharmacodynamic (PK-PD) model using individual-level data of Positive and Negative Syndrome Scale (PANSS) total score to characterize the antipsychotic drug effect taking into account the placebo effect and dropout rate. In addition, a clinical utility (CU) criterion that describ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.02.011
更新日期：2013-05-01 00:00:00
abstract：:Atypical antipsychotic drugs (AAPDs) are widely used in children and adolescents to treat a variety of psychiatric disorders. However, little is known about the long-term effects of AAPD treatment before the brain is fully developed. Indeed, we and others have previously reported that treatment of adolescent rats with...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.10.034
更新日期：2015-02-01 00:00:00
abstract：:The intracellular enzyme phospholipase A2 (PLA2) plays an essential role in the breakdown of membrane phospholipids, which regulate the physicochemical properties of the cell membrane. In the brain PLA2 has been reported to influence receptor function and signal transduction. Regarding dopaminergic neurons, data from ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(94)00060-l
更新日期：1995-07-01 00:00:00
abstract：:Grey matter brain networks are disrupted in schizophrenia, but it is still unclear at which point during the development of the illness these disruptions arise and whether these can be associated with behavioural predictors of schizophrenia. We investigated if single-subject grey matter networks were disrupted in a sa...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.08.025
更新日期：2015-10-01 00:00:00
abstract：BACKGROUND:Suicide and violence often co-occur in the general population as well as in mentally ill individuals. Few studies, however, have assessed whether these suicidal behaviors are predictive of violence risk in mental illness. AIMS:The aim of this study is to investigate whether suicidal behaviors, including sui...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.02.001
更新日期：2014-04-01 00:00:00
abstract：:To investigate relationships between birth season and biological family history in schizophrenia, this study used a sample of schizophrenics that had the advantages of (a) particularly thorough diagnostic assessments of schizophrenics' relatives, including information from direct interviews as well as chart reviews, a...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/S0920-9964(99)00162-0
更新日期：2000-08-03 00:00:00
abstract：:An earlier age at onset of schizophrenia in men as opposed to women, has been widely reported, but hitherto, insufficient account has been taken of parameters that might confound this finding. Furthermore, few explanatory models have accounted for the differences in shape of the age-at-onset distributions in males and...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(98)00070-x
更新日期：1998-10-09 00:00:00
abstract：:Although a substance use disorder (SUD) is traditionally associated with psycho-bio-social impairments, recent investigations among persons with schizophrenia (Sz) generated divergent results. Certain persons with Sz+SUD might in fact present better social and cognitive functioning than persons with Sz without SUD. Th...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析
doi：10.1016/j.schres.2007.04.022
更新日期：2008-03-01 00:00:00
abstract：OBJECTIVE:The primary aim is to examine concordant/discordant results of drug use assessments in adults with schizophrenia. METHODS:Latent class analysis and multinomial logistic regression were used to examine concordance/discordance between drug use measures and identify characteristics differentiating participants ...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2014.11.016
更新日期：2015-02-01 00:00:00
abstract：OBJECTIVE(S):To characterize the longitudinal patterns of antipsychotic treatment and to investigate the relationship between antipsychotic treatment patterns and acute hospitalizations among adults with schizophrenia. We hypothesized that continuous antipsychotic treatment would be associated with fewer hospitalizatio...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.12.475
更新日期：2008-04-01 00:00:00
abstract：:This paper examines trait arousability (TA), a temperament characteristic, in 47 stable outpatients with schizophrenia and 50 non-psychiatric controls. Self-reported levels of stress were obtained during a negative and positive memory speech task. Levels of TA, and the association of TA scores with reported stress dur...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2004.01.008
更新日期：2004-11-01 00:00:00
abstract：:A randomised trial was conducted in order to estimate the clinical and cost-effectiveness of social recovery orientated cognitive behavioural therapy (SRCBT) for people diagnosed with psychosis, compared to case management alone (CMA). The mean incremental health and social care cost, and the mean incremental quality ...
journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.schres.2009.03.041
更新日期：2009-07-01 00:00:00
abstract：:Haloperidol and reduced haloperidol plasma concentrations were measured in twelve schizophrenic patients upon cessation of haloperidol decanoate (HLD) treatment. Each patient received HLD 100 mg every 4 weeks for five injections. After the fifth injection, HLD was discontinued. Haloperidol and reduced haloperidol plas...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(93)90007-6
更新日期：1993-03-01 00:00:00
abstract：BACKGROUND:People with schizophrenia have an increased risk of premature mortality compared to the general population. We aimed to quantify which types of causes of death contributed to the excess mortality, and to examine whether there has been an increase in the excess mortality among persons with schizophrenia in th...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.11.003
更新日期：2019-04-01 00:00:00
abstract：INTRODUCTION:There is mixed evidence about emotional processing abnormalities in schizophrenia and schizoaffective disorder, with self-reports and clinician ratings indicating significant differences between patients and controls, but studies of in-the-moment, self-reported emotional experience finding only small diffe...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.schres.2019.07.013
更新日期：2019-09-01 00:00:00
abstract：:Treatments for cognitive and functional impairments associated with severe mental illnesses are urgently needed. We tested a 12-week, manualized, Compensatory Cognitive Training (CCT) intervention targeting prospective memory, attention, learning/memory, and executive functioning in the context of supported employment...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2017.08.005
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVE:Recent years have witnessed growing interest in the role of the social environment in the development and outcomes of schizophrenia. We investigated whether neighborhood characteristics are associated with two important prognostic factors in early-course psychosis, age at onset of psychosis (AOP) and duration...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.12.036
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:Childhood and adolescence represent the periods during which hallucinatory experiences occur at the greatest prevalence, and also constitute a critical window of vulnerability for the pathogenesis of psychotic disorders. The longitudinal course of hallucinatory experiences during late childhood and adolescen...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2012.03.012
更新日期：2012-07-01 00:00:00
abstract：BACKGROUND:People from culturally and linguistically diverse (CALD) backgrounds are over-represented in compulsory admissions to hospital but little is known about whether this also applies to community treatment orders (CTOs). AIMS:We investigated any differences between Australian- and foreign-born patients in the l...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.12.005
更新日期：2018-07-01 00:00:00
abstract：:Pro-inflammatory cytokines have been consistently reported to be elevated in schizophrenia patients. However, it is not known whether cytokines influence the presentation of psychotic symptoms. To address this issue, we evaluated the relationship between levels of inflammatory molecules and psychopathological paramete...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.10.019
更新日期：2013-12-01 00:00:00
abstract：:We previously reported a schizophrenia associated reduction of neuronal and oligodendrocyte number in the anterior principal thalamic nucleus (APN) in a cohort of severely impaired elderly subjects with schizophrenia (SZ) relative to age matched nonpsychiatric controls (NCs). The present study was undertaken to determ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2008.08.023
更新日期：2008-12-01 00:00:00
abstract：:The aim of this paper is to summarize ultrastructural evidence for glutamatergic dysregulation in several linked regions in postmortem schizophrenia brain. Following a brief summary of glutamate circuitry and how synapses are identified at the electron microscopic (EM) level, we will review EM pathology in the cortex ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2020.01.016
更新日期：2020-01-31 00:00:00
abstract：BACKGROUND:Prenatal micronutrient deficiency has been linked to later development of schizophrenia among offspring; however, no study has specifically investigated the association between vitamin A and this disorder. Vitamin A is an essential nutrient which is required by the early embryo and fetus for gene expression ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.02.004
更新日期：2012-05-01 00:00:00
abstract：:Low birth weight and preterm birth are important predictors of infant mortality and morbidity, and may increase the risk of schizophrenia. These adverse outcomes of pregnancy could be associated, therefore, with increased risk in children genetically predisposed to schizophrenia. The aim of this review was to describe...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/s0920-9964(98)00065-6
更新日期：1998-09-07 00:00:00
abstract：BACKGROUND:Altered motor behavior has consistently been reported in medication-naive adult patients with schizophrenia and first episode psychosis and adults at clinical high risk for psychosis (CHR). This study is the first to evaluate the prevalence of abnormal involuntary movements in a community sample of children ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.04.032
更新日期：2016-07-01 00:00:00
