Abstract：
:Pro-inflammatory cytokines have been consistently reported to be elevated in schizophrenia patients. However, it is not known whether cytokines influence the presentation of psychotic symptoms. To address this issue, we evaluated the relationship between levels of inflammatory molecules and psychopathological parameters in patients with schizophrenia. We hypothesized that severity of symptoms would correlate with increased levels of inflammatory cytokines. Serum samples from 47 veterans with a diagnosis of schizophrenia and 20 healthy controls were tested for levels of 38 cytokines/chemokines involved in regulation of immune/inflammatory reactions using a Millipore multiplex bead array in a Luminex 100 system. We found significantly increased levels of GRO, MCP-1, MDC, and sCD40L, and significantly decreased levels of IFN-γ, IL-2, IL-12p70, and IL-17, in schizophrenia patients compared to controls. In addition, we observed positive correlations between levels of cytokines and the Positive and Negative Symptoms Scale (PANSS) scores in subjects with schizophrenia for G-CSF, IL-1β, IL1ra, IL-3, IL-6, IL-9, IL-10, sCD40L and TNF-β. Pathway analyses showed these cytokines to be part of the IL17 pathway. Using principal component analyses, we found the factor that included these cytokines and IL-17 to be associated with positive, general and total PANSS scores. These results suggest that alterations in this pathway may play a role in development of psychotic symptoms in schizophrenia.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Dimitrov DH,Lee S,Yantis J,Valdez C,Paredes RM,Braida N,Velligan D,Walss-Bass Cdoi
10.1016/j.schres.2013.10.019subject
Has Abstractpub_date
2013-12-01 00:00:00pages
29-35issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(13)00565-3journal_volume
151pub_type
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doi：10.1016/s0920-9964(99)00063-8
更新日期：1999-12-21 00:00:00
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更新日期：1992-07-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2016-04-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
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更新日期：2009-06-01 00:00:00
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更新日期：2020-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.schres.2004.02.023
更新日期：2004-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.schres.2011.09.006
更新日期：2011-12-01 00:00:00
abstract：:Atypical antipsychotic drugs (AAPDs) are widely used in children and adolescents to treat a variety of psychiatric disorders. However, little is known about the long-term effects of AAPD treatment before the brain is fully developed. Indeed, we and others have previously reported that treatment of adolescent rats with...
journal_title：Schizophrenia research
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doi：10.1016/j.schres.2014.10.034
更新日期：2015-02-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
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更新日期：2009-10-01 00:00:00
abstract：BACKGROUND:Cognitive Remediation (CR) is an evidence based treatment targeting cognitive and functional difficulties in people with psychosis. Despite the large number of effectiveness studies, only limited evidence exists for the active ingredients of this therapy. This study begins to fill this gap by exploring the r...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2017.09.012
更新日期：2019-01-01 00:00:00
